Báo cáo khoa học: The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail pdf
Báo cáo khoa học: The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail pdf
... pharmacologicalfeatures of scorpion a-like toxins are associated with the flexibility of the C-tail. Results The bioactive surface of Lqh3 Twenty-four residues were substituted and the toxin mutants were ... al. a-Like toxin binding is linked to its flexibilityFEBS Journal 274 (2007) 1918–1931 ª 2007 The Authors Journal compilation ª 2007 FEBS 1931 The unique pharmacology of the scorpion a-like toxin ... differentialinteraction of Lqh3 with channel receptors of variousorigin.In total, the bioactive surface of Lqh3 is composed of two distinct domains, the Core and NC domains,formed by residues of the loop...
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Tài liệu Báo cáo khoa học: An autoinhibitory effect of the homothorax domain of Meis2 ppt
... the alternative splice site in Meis3,such that both the Meis3.1 and Meis3.2 isoforms were amplified. The relative amount of each splice form as a percentage of the totalMeis3 is plotted in the ... forMeis2d. However, the activity of the full-length Meis1awas not tested, and on the basis of our work we expectthat its activity would be inhibited by the conservedHth domain. The Meis1a isoform, ... C-terminal to the HD in Meis2d. We therefore suggest that the autoin-hibitory function of the Hth domain in Meis2d is likelyto be a common feature of Meis family proteins.Switching the AD of Meis2d...
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Tài liệu Báo cáo khoa học: Investigation and prediction of the severity of p53 mutants using parameters from structural calculations pptx
... of a severe mutant. At the otherend of the spectrum, where we have low energy, there is 75% probability for the mutation to be nonsevere if the energy is 0.125 or lower. Thus, on the basis of ... Analysis of these screens has led to the finding that the prevalence of missense somatic mutations is far more frequentthan expected. Moreover, this observation has beencomplicated by the discovery ... buried inside the protein when a sphere with the size of a water molecule van der Waals’ radius is rolled over the protein surfaceSimilarity of the surroundings* Measure of the percentage of amino...
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Tài liệu Báo cáo khoa học: Substrate specificity of the pseudouridine synthase RluD in Escherichia coli doc
... bySouthern analysis. The rluD::cat strain had a full deletion of both rluD and yfiH, together with their annotated pro-moter sequences. The inserted cat cassette had a distance of 90 nt from the ... directed isomerisarion of uridines in the helix-loop 69 of 23S rRNA occurs asa late event during assembly of the ribosomal largesubunit, but before the 50S subunit enters the 70Spool.DiscussionEach ... Japan).AcknowledgementsThis paper is dedicated to the memory of ProfessorJames Ofengand from the Univeristy of Miami. Wethank Dr U¨. Maiva¨li for critically reading the manu-script and Joachim...
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Tài liệu Báo cáo khoa học: Receptor binding characteristics of the endocrine disruptor bisphenol A for the human nuclear estrogen-related receptor c pptx
... lM) against the inverse agonist activity of 4-OHT (1 and 10 lM). The assay set marked with an asterisk shows the the inverse antagonistactivity of BPA for 1 lM 4-OHT, and the other set marked ... the b-carbon of the Ala side chain, whereas Arg has-CH2CH2NHCH(¼NH)NH2. These groups are capa-ble of making hydrogen bonds with the phenol-hydro-xyl group of BPA and also with that of ... assays. The IC50values showed a between-experimentcoefficient of variation of 4–9%. All the receptors used are the LBD of the human ERRc and its mutant receptors.Receptor binding mode of bisphenol...
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Tài liệu Báo cáo khoa học: N-terminal extension of the yeast IA3 aspartic proteinase inhibitor relaxes the strict intrinsic selectivity ppt
... castellii sequence is small comparedto that achieved by location of the full-length extensionat the N-terminal end of the polypeptide. The benefit of these alterations at each extremity of the polypeptidechain, ... the polypeptidechain, must of necessity arise from contacts that aremade outwith the active site of the enzyme. The effect of removal of the N-terminal extension The full N-terminal extension ... having (1)a cyclised Q in place of the Met1 residue at the N-ter-minus and (2) the C-terminal LE(H)6tag. It wouldthus appear that appending the His-tag at the C-termi-nus of the authentic S....
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Tài liệu Báo cáo khoa học: Salt-induced formation of the A-state of ferricytochrome c – effect of the anion charge on protein structure docx
... to the A-statemay be altered. This hypothesis is supported by dataobtained from comparison of the kinetic behavior of the mutants with that of the acid-denatured protein in the reaction with ... however, that the signal is strongerthan that recorded in the presence of monovalent ani-ons [17,18]). The intensity of the 416 nm dichroic band is $ 35% that of the native state, consistent with het-erogeneity ... that the variants undergo very fast optical (and thus structural)changes within the dead time of the stopped-flowapparatus. In the case of the K13N mutant, this hypo-thesis finds support from the...
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Tài liệu Báo cáo khoa học: Co-operative effect of the isoforms of type III antifreeze protein expressed in Notched-fin eelpout, Zoarces elongatus Kner ppt
... samples 11–14 correspond to QAE isoforms of nfeAFP, whereas the others correspond to SP iso-forms, and the TH activity of the QAE isoform is higher than that of the SP isoform.Fig. 6. TH activity ... is the species that cannotexert substantial TH activity by itself; (c) although the antifreeze activity of the SP isoform is low, it can exertTH activity with the help of the QAE isoform. The production ... case of the QAE2 isoform, nfeAFP13; the activity of its monomer was enhanced by the pres-ence of a small amount of the multimer. AlthoughCo-operative effect of type III AFP isoforms Y. Nishimiya...
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Tài liệu Báo cáo khoa học: A kinetic model of the branch-point between the methionine and threonine biosynthesis pathways in Arabidopsis thaliana doc
... plants [31,44–47].This mechanism involves the N-terminal part of CGS. The time constant of this control is unknown. If this timeconstant is much larger than the time constant of the kineticcontrols ... branch-points display a very large diversity interms of the number of the enzymes involved, the kineticmechanisms of the competing enzymes and the number aswell as the nature of the allosteric ... 7). The mathematicaltreatment of LaPorte et al. [2] is reproduced here for the Phser branch-point.When the branch-point is in steady-state, the flux of Phser(JPhser) is equal to the sum of the...
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Tài liệu Báo cáo khoa học: "On Learning Subtypes of the Part-Whole Relation: Do Not Mix your Seeds" pdf
... tuples were discarded. The precision of the tuples discovered by the different seed-sets in the last iteration of our algorithm are in Table 3.These results reveal that the precision of har-vested ... that the precision of tuples extracted fromboth the English and Dutch corpora by the gen-eral set of mixed seeds was as high as the max-imum precision obtained by the individual sets of specialized ... “whole” entitieswere then discovered from documents in the queryresults with a precision of 74%. The part-wholerelation is also a benchmark to evaluate the perfor-mance of general information...
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Từ khóa: Báo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát hiện xâm nhập dựa trên thuật toán k meansThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíChuong 2 nhận dạng rui roKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ