... catalyticefficiency, the overall functional defect of G372A-FVIIa was, if anything, smaller in the presence of TF,which suggests that the allosteric effect of TF, influenc-ing burial of the N-terminus, and the ... conformational plasticity of FVIIa,especially in the vicinity of the S1 pocket [11,34], in the first part of activation loop 3, and in the area of the TF-interactive helix and the 170 loop [8,35], areasthat ... cleavage of the scissile bond. This would affect FX and peptidehydrolysis similarly, supported by the similar decreasein the rate of cleavage of both types of substrates. The effect of the G372(223)A...