... USA) at the ÔServeis Cientifico-TecnicsÕ of the University of Barcelona,using the 488 nm line of an argon laser and standard opticalemission filters. Percentages of cells at each phase of the cellcycle ... after78 h. The levels of p53 in cells continuously treated withWP631 decreased, which was consistent with the suppres-sion of the arrest in G2/M, the production of polyploidy,and the final ... that the improved antitumorefficacy of WP631 on some cell lines [8,9] might be the result of its strong effect on the transcription of some key genes,such as p53 and c-myc [16]. The inhibition of...