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Báo cáo Y học: Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae ppt

Báo cáo Y học: Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae ppt

Báo cáo Y học: Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae ppt

... Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae Stuart M. Ingleston1, Mark J. Dickman2, Jane A. Grasby3, David P. Hornby2, Gary J. Sharples4 and ... specificity of MpRuvA by analysing its binding to a Y- shaped junction and to linear duplex DNA. Like the E. coli protein, MpRuvA formed two complexes with a Y junction. However, as with the f our-way junction, ... DNA than EcRuvA (Fig. 2B). The kdvaluesestimated from t hese data were 18 nMfor MpRuvA and 42 nMfor EcRuvA.Specificity of Holliday junction binding by Mp RuvA The E. coli RuvA protein targets...
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Báo cáo Y học: S-Decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1) ppt

Báo cáo Y học: S-Decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1) ppt

... University of Groningen,Haren, the Netherlands;2Department of Gasteroenterology and Hepatology, University Hospital Groningen, the Netherlands;3Department of Medical Oncology, University Hospital ... can be explained by assuming the presence of one high-affinity stimulatory binding site, and one low-affinity inhibitory binding site.These sites may be identical to the on and off sites, whichare ... were kindly provided by colleagues: the MBP fusion protein of the NBD of the lactococcal half-transporter LmrA (residues Glu328-Lys590) by M. Pasmooij (Groningen University, the Netherlands);...
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Tài liệu Báo cáo Y học: Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima A new insight in the biomineralization field pptx

Tài liệu Báo cáo Y học: Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima A new insight in the biomineralization field pptx

... antibody revealed the complexity of this kind of matrix, with several closely separated bands [50]. The EDTA-SM showed a 14-kDa band, probably the N14 protein found by Kono et al. [14], and another ... Proline, hydroxyproline and hydroxylysine were examined at 254 nm by reverse-phaseHPLC of their phenylisothiocarbamate derivatives [26], asreported previously [20]. The serine, threonine and tyrosinecontents ... composition was very similar to the WSM, and consequently the EDTA-IM. Hydroxyproline, hydroxy-lysine and phosphoserine were not detected in WSM, WIM,EDTA-SM and EDTA-IM. The comparison of the amino...
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Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx

Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx

... decades of life and severely impair visualacuity in adulthood. Their therapy is restricted to keratopl-asty and phototherapeutic keratectomy by Excimer laser.Unfortunately, the benefits of these therapies ... in a phenotypic variant of granular cornealdystrophy type 1 (GCD1), Arg124His (R124H) [1] ingranular corneal dystrophy type 2 (GCD2, Avellinodystrophy) a mixed type of amyloid and granular ... peptide.Hereditary corneal dystrophies are a cause of blindness.These dystrophies are characterized by a progressivealteration of the particular structure of the cornea resultingin loss of its transparency....
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Tài liệu Báo cáo Y học: Interallelic complementation provides genetic evidence for the multimeric organization of the Phycomyces blakesleeanus phytoene dehydrogenase doc

Tài liệu Báo cáo Y học: Interallelic complementation provides genetic evidence for the multimeric organization of the Phycomyces blakesleeanus phytoene dehydrogenase doc

... bothZygomycetes. In Phycomyces they complement neither the carR nor the carA mutants, and i n Mucor they complementneither the carP nor the carR mutants. They are white, l ackall carotenoids and ... carotenoid pathway to b-carot eneproceeds via three enzymatic steps carried out by the enzymes phytoene synthase, phytoene dehydrogenase and lycopene cyclase. The enzyme phytoene dehydrogenase isable ... gram dry weight) by spectrophotometricanalysis (SP) or by HPLC analysis (HPLC) of the amounts of the dierent carotenoids accumulated by strains NRRL1555 and A486.P, phytoene ; PF, phyto¯uene;...
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Báo cáo khoa học: Androgen receptor function is modulated by the tissue-specific AR45 variant ppt

Báo cáo khoa học: Androgen receptor function is modulated by the tissue-specific AR45 variant ppt

... activity of AR45 might belinked to poor coactivator recruitment, due to the absence of the NTD. This might be overcome by the overexpression of cofactors. To test this hypothesis, weanalyzed the ... lying between the first and the second exon of the AR gene. AR45 may therefore originate from tran-scription controlled by a novel promoter region lyingupstream of exon 1B. Interestingly, the ... panels of cofactors may accountfor some of these effects [18]. Another possibilityarises from the existence of variant forms of steroidreceptors. The estrogen receptor (ER) probablybelongs to the...
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Báo cáo y học:

Báo cáo y học: "Lifetime health effects and medical costs of integrated stroke services - a non-randomized controlled cluster-trial based life table approach"

... risk of recurrence, case-fatality rate of stroke, probability of dis-ability after stroke, and the four probabilities of death -affect patients’ courses in the same way as they did in the original ... toincrease. In 20 years, the prevalence of stroke in the Netherlands will be more than 40% higher as a result of aging of the population, continuing unhealthy lifestylesamong elderly, and improved care ... revalidation centre and home) at which the patient stayed during this per-iod, weighted by the length of stay. Costs of care for the second half year after stroke were based on place of residence data...
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Báo cáo y học:

Báo cáo y học: "2009 H1N1 Influenza and Experience in Three Critical Care Unit"

... cultures. Of the 61 patients, all of them received oselta-mivir. The mean time from the onset of illness to the initiation of antiviral therapy was 7.4±4.17 days (range, 1 to 22 days); 2 of the ... that relatively younger pa-tients are affected by the disease. Fever and respira-tory symptoms were cardinal symptoms of disease in all patients. There was a relatively long period of ill-ness ... microbiology laboratory for detection of bacterial infection in inva-sive and noninvasive mechanically ventilated pa-tients. The body-mass index (BMI, weight in kilo-grams divided by the square of the...
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Báo cáo y học:

Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"

... Among the six genotypes of HCV, the most common geno-types of HCV in the United States are genotype 1 (approximately 75%), genotype 2 (15%), and geno-type 3 (7%) (2-5). At present, the standard ... detection of 28 IU/mL. Body weight measurement and laboratory data were collected and compared at the beginning and at the end of therapy. The Knodell scoring sys-tem for liver biopsy (obtained ... reviewed. The majority of the study population was male (67%) and Caucasian (57%) with the mean age of 52.5 years (Table 1). Fifty six percent were infected with genotype 1, 16% with genotype 2 and...
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