Báo cáo Y học: Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells deﬁne structural determinants of receptor function doc

... Loss -of- function variants of the human melanocortin-1 receptor gene in melanoma cells deﬁne structural determinants of receptor function Jesu´sSa´nchez Ma´s1, ... that impairment of signaling through the cAMPcascade occurs in these cells even in the absence of mutations in the coding region of the gene. Finally, ourstudy of the natural MC1R variants highlights ... particularly in all members of the melanocortin receptors subfamily.WenexttriedtocorrelatetheMC1R genotype of several of the HMC lines with their degree of responsiveness toagonists, by studying their...

Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"

... of body or tail of the pancreas. For tumors of SPT located in the neck and body of the pancreas, resection of the mid-portion of the pancreas and the mass with preserving the rim of the head ... might in turn result in the uncertainty of the strategy for its treatment. While further delineati n g the clinicopathological and radiological features, and summarizing the surgical therapy strategy ... complaint was abdominal pain (8/18). The rest of the patients were asymptomatic and tumors were de-tected incidentally during routine physical examina-tion. All these patients had no other...

Tài liệu Báo cáo Y học: Dinucleoside polyphosphates stimulate the primer independent synthesis of poly(A) catalyzed by yeast poly(A) polymerase ppt

... catalyze the synthesis of a poly(A) chain in the absence of a primer [1]. In orderto explore whether the yeast enzyme also exhibited the same properties we assayed, in parallel, the activity of both ... the synthesis of poly(A)catalyzed by yeast poly(A) polymerase. The relativeactivity of diadenosine polyphosphates as effectors of the poly(A) synthesis was assayed as in Fig. 4, using0.05 mM[a-32P]ATP ... independent synthesis of poly(A) In order to understand why dinucleoside polyphosphatesactivated the primer independent synthesis of poly(A), the effect of 0.01 mMGp4GorAp4A on the synthesis of poly(A)...

Báo cáo y học: "Users' guides to the medical literature: how to use an article about mortality in a humanitarian emergency"

... keep in mind when reading amortality survey to determine the validity of the study and the applicability of the findings to theirsettings.Public health scenarioYou are a physician working ... considers whether the mortality estimatesreported in the article accurately represent the magnitude of the problem. Another way to state this question is: Do the findings of the study represent ... mortality isoccurring, by comparing the observed mortality rate with the best available estimate of the baseline mortality rate in the pre-war period, either by subtraction or by modellinga relative...

Báo cáo y học: "Placenta Percreta-Induced Uterine Rupture Diagnosed By Laparoscopy in the First Trimester"

... Because the amount of blood in the ruptured area increased rapidly, we de-cided to convert laparoscopy to laparotomy. At the beginning of the laparotomy, the fetus was sponta-neously delivered ... early as 9 weeks of gestation [6]. In most cases of uterine ruptures that occur during delivery, the af-fected site is the lower uterine segment; however, in cases of uterine rupture during the ... hemoperitoneum. The gradual increase in the size of the uterus with advancing pregnancy can cause a delay in the diagnosis and appropriate treatment. The first laparoscopic surgery during pregnancy was...

Báo cáo y học: "Transporter Molecules influence the Gene Expression in HeLa Cells"

... determine the global players involved in such complex phenotypes. Integration of the gene expres-sion profiling with specific modulation of gene ex-pression in relevant signalling pathway models ... processing and analyzing with Illumina’s BeadStudio Data Analysis Software and are described in the following part according the defini-tions of the Illumina’s (ILL) data as well as of the Il-lumina’s ... http://www.geneontology.org/) of the differentially expressed genes are shown in table 4. Figure 3. Comparison of the expression level of the reference genes. The main modified genes (grey in...

Báo cáo Y học: Cold induces stress-activated protein kinase-mediated response in the ﬁssion yeast Schizosaccharomyces pombe pot

... induced a strongactivation of Sty1p kinase. In this context, we tried toestimate the levels of Sty1p phosphorylation in strain TS-2(wak1–, Sty1p-Ha6H) to determine the role of Wak1p in the cold-induced ... phosphorylation in strain TS-2 only at180 min, which corresponds to the maximum of Sty1pactivation in wild-type strains (see Fig. 1). Also, we studied the level of Sty1p activation in strain TS-2 ... akey element in the regulation of Sty1p activation by cold in S. pombe. However, the existence of some Sty1p activation in the absence of Wak1p reveals that to some extent otherMEKK, likely Win1p,...

Báo cáo Y học: Calcium-binding by p26olf, an S100-like protein in the frog olfactory epithelium pot

... constants of the first to fourth binding of Ca21by assuming the presence of four steps of sequential and ordered binding. To identify the site of the EF-hand corresponding to the nth binding of Ca21, ... K1con-centration, 80– 90% of the change in the a helix contentwas attained by binding of two Ca21. Interestingly, in the mutants which have only three Ca21-binding sites, the binding of two Ca21was ... determine the affinity for Ca21and the cooperativity of Ca21-binding to p26olf, we next analyzed the stoichiometry of Ca21-binding to p26olf by flow dialysis in the Tris buffer. Ca21-binding...

Báo cáo khoa học: "A CONSIDERATION ON THE CONCEPTS STRUCTURE AND LANGUAGE IN RELATION TO SELECTIONS OF TRANSLATION EQUIVALENTS OF VERBS IN MACHINE TRANSLATION SYSTEMS" doc

... verb found in the process of the association, consults ordinary dictionary of translation equivalents and word usage of verbs and obtain the set of all the translation euqivalents for the verb. ... associated infor- mation relating source and target languages. Discussion have been made from the standpoint of realizability of the structure (e.g. from the standpoint of easiness of data collection ... meanigns of 'play' but need to assign different translation euqivalents according as the differences of contexts in the case of 1. to 3., and due to multiple meanings in the cases of 4....

Báo cáo y học: " Autonomic Dysfunction Presenting as Postural Orthostatic Tachycardia Syndrome in Patients with Multiple Sclerosis"

... the amount of activity per-formed. Many patients complain of feeling exhausted on waking, even if they have slept soundly. Fatigue can also occur during the day but may be only par-tially ... minimizing symptoms was initiated in each patient following the diagnosis of POTS. The majority of these patients were on selective serotonin reuptake inhibitors (venlafaxine and du-loxetine) ... orthostatic tachycardia syndrome (POTS) in patients suf-fering from MS. Methods: The patients were included for analysis in this study if they had POTS with either a prior history of MS or having developed...

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