... Indeed, the enzymestands at a branch point of the tryptophan to NAD pathway, and deter-mines the final fate of the amino acid, i.e. transformation into PA, com-plete oxidation through the citric ... Arg47 and the Phe294-Pro295-Leu296 amino acid stretch (Fig. 3A,B). The ligand binds in an extended conformation, with itsphosphate moiety located in the proximity of the zincion and with the ... ª 2009 The Authors Journal compilation ª 2009 FEBSmechanisms proposed for ACMSD [21], the hA-CMSD:DHAP complex represents the first structure of an ACMSD in a ligand-bound form and can be usedto...