... Journal compilation ª 2006 FEBS Coiled–coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms Rene´E. M. A. van ... domainmodulates myotonic dystrophy protein kinase multimerization, substrate binding, kinase activity and subcellular localization characteristics.AbbreviationsCM, coil mutant; DMPK, myotonic dystrophy ... isoforms A and C, which hasbeen described previously [5,15].Fig. 1. Myotonic dystrophy protein kinase (DMPK) isoforms and truncation mutants. Structural domain organization of DMPK splice isoforms A,...