Báo cáo khoa học: Dehydroepiandrosterone inhibits the proliferation and induces the death of HPV-positive and HPV-negative cervical cancer cells through an androgen- and estrogen-receptor independent mechanism pptx

... 5609 Dehydroepiandrosterone inhibits the proliferation and induces the death of HPV-positive and HPV-negative cervical cancer cells through an androgen- and estrogen-receptor independent mechanism Roma ... Dehydroepiandrosterone inhibits the prolifera-tion of HUVEC by enhancing the expression of p53 and p21, restricting the phosphorylation of RB, and is androgen- and estrogen-receptor independent. FEBS ... on the proliferation and death of three cell lines derived from human cervical cancersassociated with human papilloma virus (HPV) and positive for the estrogen receptor, and to determinewhether...

Báo cáo khoa học: Pleiotrophin inhibits HIV infection by binding the cell surface-expressed nucleolin docx

... alsoimplicated in the mechanism of PTN binding to cells. This is somewhat analogous to the mechanism of HIVbinding cells in which both heparan and chondroitinsulfate proteoglycans and nucleolin ... coordination of at least two eventsimplicating on the one hand heparan sulfate proteo-glycans [6,7] and on the other hand the cell surface-expressed nucleolin [4]. In the search for naturalligands of ... to the lack of heparan sulfate and heparan ⁄ chondroitin sulfate proteoglycan expression, and illustrates the implication of such proteoglycansin the HIV attachment process. The capacity of HB-19...

Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx

... helptranslate the cellular and biochemical insights into a better understanding of disease mechanism. In this minireview, we discuss the contributions of animal models to our growing understanding of the ... models are relevant to disease to the degree thatthey help us further understand the human phenotype.Recent investigations have further reﬁned our under-standing of this phenotype, and bear reviewing ... effusions may variably be the mechanism of death, a common theme throughoutwas disruption of the cell–cell junctions within the endothelial or endocardial cells. Heg1 and Ccm2 werealso shown...

Báo cáo khoa học: A new molecular tool for transgenic diatoms Control of mRNA and protein biosynthesis by an inducible promoter–terminator cassette docx

... that the 5¢-UTR and 3¢-UTR of CfNR allow control of both the timing and level of expression of introducedgenes in transgenic C. fusiformis.ResultsIncreasing the efficiency of C. fusiformistransformationPreviously, ... Structure of transformation plasmid pNICgfp and analysis of GFP expressing C. fusiformis transformants. (A) Restriction map of the part of plasmid pNICgfp containing the egfp gene flanked by the Pnr ... observation of the protein’sinfluence on the progression of the cell cycle and the silica biogenesis. As the regulation of NR expressionappears to be very similar throughout the diatomrealm [12,13], the...

Báo cáo khoa học: Dictyostelium differentiation-inducing factor-1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells pdf

... membrane in the cells, although we cannotexclude the possibility of the involvement of someGLUT isoform(s) other than GLUTs1–4.Glucose uptake and GLUT1 expression areenhanced in cancer cells and ... inRGM-1 cells, mouse 3T3-L1 ﬁbroblasts, and 3T3-L1 adi-pocytes, and investigated the mechanism of the novelfunction of DIF-1. We show here that DIF-1 induces the translocation of glucose transporter ... of DIF-1 and insulin on the glucose uptake and GLUT translocation in 3T3-L1 adipocytes3T3-L1 adipocytes are well-established model cells suitable for the analysis of the actions of insulin and other...

Báo cáo khoa học: "A Unification-based Approach to Morpho-syntactic Parsing of Agglutinative and Other (Highly) Inflectional Languages" doc

... follows: An f feature of the D description can have either a single value or a set of values. An f feature of the D description has compatible values in the E description iffone of the values of ... [ADV] way of handling compounding and adequate handling of derivational affixes. Recent implementations of Humor 99 define the set of possible morpheme sequences by means of the so-called ... spite of the fact that English morphology is simpler than the morphologies of agglutinative and highly inflectional languages. 2 Depth of the recursive process can be given as a parameter. The...

Báo cáo khoa học: "A Unification-based Approach to Morpho-syntactic Parsing of Agglutinative and Other (Highly) Inflectional Languages" ppt

Báo cáo khoa học: Hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis and the proliferation of HepG2 cells pot

... biosynthesis of PC in HepG2 cells at the level of CTactivity. It interferes with the translocation process of CTfrom the cytosol to the membrane and ﬁnally leads to an inhibition of the biosynthesis ... oleate activates the PC synthesis in HepG2 cells increasing the CT activity.Thence, in another set of experiments we assayed the combined effect of HePC and oleate. As it can be observedin ... was removed and the labelled cells were incubated for an additional period of 6 heither in the presence or absence of HePC. The resultsindicate that the APC did not affect the rate of intracellularPC...

Báo cáo khoa học: Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding Pallavi Srivastava and Dulal Panda ppt

... F0, Fc and DFmaxrepresent the fluorescence intensity of tubulin in the absence of rotenone, the fluorescence intensity of tubulin in the presence of different concentrations of ligand and the maximum ... significant insightwith respect to the antiproliferative mechanism of action of rotenone.ResultsEffects of rotenone on the proliferation HeLa and MCF-7 cells Rotenone inhibited the proliferation of ... morphological and biochemical changes in the cell. One of thesechanges is the exposure of phosphtidylserine on the surface of the cell membrane during the early stage of apoptosis. Annexin V is...

Báo cáo khoa học: Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways doc

... the differentiation of skin cancer cells with subsequentinhibition of proliferation [16], and induction of cell death was mediated via P2X7receptors in skin cancer and prostate cancer cells [16,17]. The formation ... LXF-289 cells in the presence of ATP. These anticancer substances inhibit cell cycleprogression by different mechanisms and form the basis of current chemotherapeutic regimens in lung cancer treatment. ... of LXF-289 cells in the S phase, where cells are especially sensi-tive to anticancer drugs. Therefore, we used cisplatin,etoposide and paclitaxel to investigate the effects of these anticancer...

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