... whichreaches an 84% of the residues. Structural analysis con-firmed the existence of two helical peptide fragments. Thefirst was comprised of residues Ile6–Arg16 and the second of residues Glu20–Ile40, ... binding and exertion of action [13]. Thestudy of this molecule has led to the development of agonistsCorrespondence to P. Cordopatis, Department of Pharmacy,University of Patras, GR-265 04, ... major goal of our study is the solution structuredetermination of a CRH analogue devoid of any agonistactivity, a fact particularly relevant to the further design anddevelopment of CRH antagonists...