. F. Cheng, and R. C. Harris, Am. J. Physiol. 273, F554-F562 (1997). 57. S. Gorina and N. Pavletich, Science 274, 1001-1005 (1996). 58. V. Mandiyan, J. Andreev, J. Schlessinger, and S. R.. -300 mV and below (J. Heo and P. W. Ludden, personal communication), and the behavior of CooA is consistent with this fact. CooA is competent to bind CO only when its heme is re- duced, and the. clones and reflect insertions of 52, 53, and 168 bp, respectively, that do not occur in the transcripts encoding LH- and S H-iPLA2/~ isoforms (11). Indeed, these insertions arise from introns and...