... extracellularlyas a ligand that either acts as a juxtacrine factor ormediates transactivation of a distant unknown recep-tor. Ectodomain cleavage would terminate RING-med-iated ubiquitination ... nuclear membrane. J Cell Biol 180, 763–769.51 Isokane M, Hieda M, Hirakawa S, Shudou M,Nakashiro K, Hashimoto K, Hamakawa H &Higashiyama S (2008) Plasma-membrane-anchoredgrowth factor ... ectodomain-cleaving proteases.Additional fragments of RNF13 are variablydetected, such as an HA-tagged form lacking theC-terminal FLAG epitope (Fig. 3, lane 5, asterisk) [2],suggesting that additional...