... and the lifespan of the complex by 10-fold, as judged by koff. The physiologicalchaperone cycle probably consists of the rapid binding of the N-terminus of the partner, regardless of whetherit ... enthalpy is the sum of twoterms: the reaction enthalpy, independent of the bufferused in the experiment, and another term representing the contribution of the proton ionization of the buffer,which ... completion of the maturation process of the partner. The nature of the signal that may trigger dissociation of the complexremains unclear; however, we propose that a localperturbation of the hydrogen...