... susceptible. These findings show that the presence of Val67 is one of the essential factors responsible for the actin-binding capacity of these snake DNases I.Tissue distribution of snake DNases I The ... be involved in changing the thermally stable characteristics of vertebrateDNases I, substitution of Ile130Leu in snakes and insertion of Ser205 in amphibia. It is interesting that DNases I of warm-blooded ... [4,5 ,15 ,17 ,19 ]. When the primary structures of the three snake enzymes were compared with those of othervertebrates, only two aa residues, Leu130 and Leu166, of Fig. 2. Alignment of the amino acid...