Báo cáo Y học: Rodent a-chymases are elastase-like proteases pot
Báo cáo Y học: Rodent a-chymases are elastase-like proteases pot
... homology with other a-chymases of primates anddogs, rodent a-chymases were predicted to be chymo-trypisin-like proteases that have very similar substrate spe-cificity to those of other a-chymases. ... rodent a-chymases with Val216 (Fig. 6). These results strongly suggest that allfour rodent a-chymases are elastase-like proteases that are evolutionarily close to each other.The chymase phylogenetic ... specificity and inhibitor profiles, rodent a-chy-mases are elastase-like serine proteases. To our knowledge,the mast cell chymases that have been enzymaticallycharacterized to date are all chymotrypsin-like...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... ¼ 1 and n ¼ 3.bNi(II) data from ref [11].c[31].d[36].eglycylglycylhistamine, [9].fa-hydroxymetylseryl-a-hydroxymetylserylhistidinamide; Cu(II) data from [37]; Ni(II) data from [38].gN-Terminal ... pooled and lyophilized to yield with solid ofpurity exceeding 99% as assessed by HPLC analysis of thefinal m aterials. I dentity and purity of peptide was confirmedby mass spectrometry, utilizing ... Bal1,21Faculty of Chemistry, University of Wroclaw, Poland;2Institute of Biochemistry and Biophysics, Polish Academy of Sciences,Warsaw, PolandA comparative study of thermodynamic and kinetic...
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Tài liệu Báo cáo Y học: Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors potx
... transduction pathways, such asthe classical ternary complex factors, that are activated byMAP-kinase pathways [18].Several nonvertebrate SRF homologues have beendescribed that are mainly involved ... was kindly provided by U. Moe¨ns(University of Tromso, Norway) [31].The expression vector pcDNA3-myc was generated byinserting a BamHI–EcoRI fragment that codes for six copiesof myc epitope, ... or noantibody (–), and anti-myc Ig for Western blotting. Anti-myc Ig rec-ognized human (HsSRF-myc), D. melanogaster (DmSRF-myc) andA. franciscana (AfSRF-myc) SRFs fused to the myc epitope whosemigration...
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Báo cáo y học: "Characterization of Human Erythrocytes as Potential Carrier for Pravastatin: An In Vitro Study"
... com-pared to that of unloaded erythrocytes (Table 4). Table 4, Erythrocyte osmotic fragility of unloaded eryth-rocytes and erythrocytes loaded with 8, 4 and 2 mg/ml pravastatin. Values are ... in erythrocytes either by physical methods such as endocytosis and osmosis-based systems or by chemical perturbation of the erythrocytes membrane [16]. Endocytosis is the process by which cells ... loaded erythrocytes Hematological Indices To determine the effect of loading process on erythrocytes, normal erythrocytes, erythrocytes sus-pended in PBS, and pravastatin-loaded erythrocytes...
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Báo cáo Y học: Characterization of a low redox potential laccase from the basidiomycete C30 pptx
... (one type 2 and two type 3) responsible for thefour electron reduction of dioxygen [3]. These enzymes are common in plants, fungi, insects and bacteria [1]. In plants,they may mainly play a role ... basidiomycete produces, in vivo,enzymeforms with such different behaviors are discussed.Keywords: metalloenzyme; copper; redox potential; laccase;basidiomycete C30.Laccases (EC 1.10.3.2) catalyze ... shares69% identity (79% similarity) with LAC1 and 81% identity(95% similarity) with Lcc3-2 from Polyporus ciliatus (AF176321-1), its nearest neighbor in database. Possiblereasons for why...
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Báo cáo y học: "Why are some children with early onset of asthma getting better over the years" -aneuploid-prostate-cancer-cells-after-tmz-tmz-bioshuttle-treatment.html#post143974
... (19). Interestingly, the exposition for pet animals tended to be higher in the NA cases, which may support the hygiene hypothesis, but may also be due to higher sensitivity in the A group. ... hospital or primary health care diagnosis of asthma at least once between 0-7 years of age in a total birth-year cohort in a defined Swedish geographical area. A multiple logistic analysis revealed ... to aller-gens which were previously encountered early in life, but are now disappearing in modern affluent societies (6). However, this so called hygiene hypothesis based on the role of infection...
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Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"
... evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J Biol Chem 1997; 272: 31941-4. 29. Bryant HE, and Helleday T. Poly(ADP-ribose) polymerase inhibitors as potential ... V-C8, compared with the BRCA2 wild type control, exhibited extreme sensitivity to AG14361, a very potent PARP-1 inhibitor (KI=5nM), and NU1025, a moderately potent PARP-1 inhibitor (KI =50nM). ... cancer cells? Because PARP-1-null mice are viable and healthy [32], and inhibitors that are specific for PARP-1 are relatively non-toxic and do not directly damage DNA, PARP-1 inhibitors might...
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Báo cáo y học: "Prion propagation in vitro: are we there yet"
... infectivity. Autocatalytic Conversion Assay Baskakov developed a novel in vitro system re-ferred to as the autocatalytic conversion assay. The principle of this assay heavily relies on ... infectivity.23 Cell-Lysate Conversion Assay Saborio et al. introduced a system termed the cell-lysate conversion assay.24 This method describes incubating lysate of Chinese hamster ovary cells over-expressing ... Microbiology, Immunology & Molecular Genetics, University of Ken-tucky College of Medicine, Lexington, KY, U.S.A. Correspondence to: Dr. Chongsuk Ryou, 800 Rose St. HSRB-326, Lexington, KY 40536....
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Tài liệu Báo cáo Y học: Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis docx
... phosphatidylinositol; PtdOH, phosphatidicacid; CDP-DAG, CDP-diacylglycerol; CMP, cytidinemonophosphate; CTP, cytidine triphosphate.Enzymes: phosphatidylinositol synthase or CDP-diacylglycerol/myo-inositol ... novosynthesis, catalysed by phosphatidylinositol synthase (EC2.7.8.11), also known as CDP-diacylglycerol (DAG)/myo-inositol 3-phosphatidyltransferase, and an exchange reac-tion whereby the sugar head ... novo synthesis of PtdIns is most active. Thoroughenzymatic characterization of synthesis and exchange hasattemptedtounderstandifbothreactionsaremediatedbythe same enzyme, but only one study has...
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Báo cáo Y học: Two GPX-like proteins from Lycopersicon esculentum and Helianthus annuus are antioxidant enzymes with phospholipid hydroperoxide glutathione peroxidase and thioredoxin peroxidase activities pptx
... selenocysteine in mammalGPXs. The selenocysteine residue is important for thecatalytic activity of GPX as replacement of selenocysteine bycysteine greatly reduces the activity of the enzyme [12].According ... affinity towards phospholipidhydroperoxides and a weaker affinity towards t-butylhydroperoxide, as indicated by their respective apparentKmvalues. There was no detectable activity with hydrogenperoxide.Considering ... acid andL-a-phos-phatidylcholine dilinoleoyl hydroperoxides were preparedusing soybean lipoxidase as described previously [20].Hydroperoxides formation was monitored by followingthe change...
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