... interferon -a andinterferon-c through induced synthesis of one subunit ofthe transcription factor ISGF3. EMBO J 9, 110 5–1 111.10 Tamada Y, Nakao K, Nagayama Y, Nakata K,Ichikawa T, Kawamata Y, Ishikawa ... Nakao K, Nakata K, Yamashita M, Tamada Y,Hamasaki K, Ishikawa H, Kato Y, Eguchi K & Ishii N(1999) p48 (ISGF-3c) is involved in interferon -a- induced suppression of hepatitis B virus enhancer-1activity. ... (IFN) are important components of the innate antiviralresponse. A key signalling pathway activated by IFNa is the Janus kinase ⁄signal transducer and activator of transcription (JAK ⁄ STAT) pathway.Major...