Báo cáo khoa học: The inﬂuence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor pot

Báo cáo khoa học: Nerve inﬂuence on myosin light chain phosphorylation in slow and fast skeletal muscles pdf

... favour of the existence of a long-term regulation of MLC2 phosphorylation, besides the short-term regulation that is dependent on calciumreleased during contraction. Long-term regulationmeans ... decrease of mass)when compared with the corresponding muscles of the control animals (CONT) or with the muscles of the controlateral unoperated limb (CODE). The distribution of MHC and MLC isoforms ... Denervation of EDL modiﬁed the relative proportion of the variants of MLC2slow,as the more acidic spot (2s2) signiﬁcantly decreased(Fig. 2, arrow, and Table 3). The proportions of the spots corresponding...

Báo cáo khoa học: From functional genomics to systems biology Meeting report based on the presentations at the 3rd EMBL Biennial Symposium 2006 (Heidelberg, Germany) Sergii Ivakhno pot

... metabolism. The functional association wasfurther aided by integration of protein interactiondata with data on gene expression, localization, func-tion, evolutionary conservation, protein structure ... temporal patterns of Mef2 target generegulation. Although most of the reported transcriptionnetworks based on chip -on- chip data are static, Fur-long described one of the ﬁrst examples of a dynamictranscription ... three or more layers of transcriptionalcontrol. The ﬁrst layer consists of global regulatorswhich control the expression of many genes in manydifferent systems. The second layer involves ‘masterregulators’...

Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc

... shielding most of the upper surface of the b-sheet from the environment. Upon dimerization, exten-sive contacts are formed between the subunits so that the b-sheet becomes extended to form a continuous10-stranded ... measurements of WT MS2 as a function of urea concentration. To verify the dissociation and denaturation processes, we measured the light scattering of the particlesat 320 nm (d)andthespectralcenterofmassoftheparticles(s). ... wavenumbermi and the summation is carried out over the range of appreciable values of F. The values of center of spectralmass of tryptophan were converted into degree of denatur-ation/dissociation (ap),...

Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc

... of the purifieddioxygenase to the reaction mixture with a large excess of the purified enzyme reported here to avoid the formation of 2,5-pyridinedicarboxylic acid from 2-amino-5-carboxy-muconic ... to2,5-pyridinedicarboxylic acid based on the wavelength [10].Purification and properties of the purified enzyme The activity of the enzyme present in the crude extract of strain 10d that used 2 -amino-5-carboxymuconic ... characterization of the purified enzyme The c oncentrated enzyme solution (fraction 6) was yellow i ncolor. The enzyme s olution showed one main absorptionpeak at 266 nm and a broad absorption band in the...

Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform speciﬁcity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx

... at the end of the titration, even afteraddition of excess Cu(I), some species still retainedZn(II) ions. The discussion of the Cu(I) coordination behaviorbecomes more complex in view of the ... under the same conditions as described for the holo-forms, with the following exceptions for releasing Zn(II) ions but notCu(I) ions from the complexes: the liquid carrier was a5 : 95 mixture of ... induction confers abasic detoxiﬁcation role to this isoform. This hypothe-sis is also concordant with the effects observed in the ﬁtness of C. elegans MT-knockout organisms, where the lack of CeMT1...

Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

... chordates possessonly one syndecan, which is essential for neuronaldevelopment and axon guidance [1,2]. All cells expressat least one member of the syndecan family [3], with the exception of erythrocytes. ... whereasothers partners are the actin-associated protein a-acti-nin as well as syndesmos, about whose function ratherlittle is known [10]. The transmembrane domain of allsyndecans contains a GXXXG ... 2010)doi:10.1111/j.1742-4658.2010.07798 .x Proteolytic processes in the extracellular matrix are a major inﬂuence on cell adhesion, migration, survival, differentiation and proliferation. The syndecan cell-surface...

Báo cáo khoa học: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster ppt

... inﬂuence on the yield of GDP-Fuc.Furthermore, reduced conversion of the intermediatewas observed in the absence of dithiothreitol. On the basis of these data, we did not alter the assay mixturecomposition ... than the con-version of GDP-Man into products in the presence of both enzymes (e.g. with Drosophila GMD alone the conversion of GDP-Man into the intermediate was 80%, whereas in the presence of ... Residues conserved in comparison with the ﬂy and worm sequences are highlighted, whereaskey conserved residues noted in the Discussion (GXXGXXG as well as the Ser ⁄ Thr residue and YXXXK motif...

Báo cáo khoa học: "Search in the Lost Sense of “Query”: Question Formulation in Web Search Queries and its Temporal Change" pptx

... compute a linear regression of Q-level across 12 months, conduct a hypothesistest (with the null hypothesis being the slope of the regression equal to zero), and report the P -value fortwo-tailed ... not on clusteringbut on understanding the expression of intent.3 MethodWe address the main thesis of the work by retrospec-tively studying queries issued to a search engine over the course of ... questions to ex-press their search intent.1 IntroductionA web search query is the text users enter into the search box of a search engine to describe their infor-mation need. By dictionary...

Báo cáo khoa học: "Lexicalization in Crosslinguistic Probabilistic Parsing: The Case of French" potx

... The effect of this decision needs to be investigated infuture work.XP X COORDC XP X XP X C XP X XP X C X Figure 3: Coordination in the FTB: before (left) andafter transformation (middle); ... shows that the poor POS tagging performed by BitPar is one of the reasons of the poor performance of the lexicalizedmodels. The impact of perfect tagging is less dras-tic on the lexicalized ... with the cattag of the compound. Thisheuristic produces the correct POS for the subparts of the compound most of the time.2An alternative would be to retain the cattag of the com-pound. The...

Báo cáo khoa học: Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa potx

... hydrogen bond interactions with the backbones of A299 (7.46) and G51, which stabilize the distorted con-formation of TM7 around the NPxxY motif. The samecrystal structure contains one water ... Because of the stronger effect of Gta-HAA in shifting the altered conformation of G51V, wefocused on this mutant for the double mutant studiesdescribed in the following sections. The stronger ... activationobserved. In terms of the thermal stability, the activeconformation of the G51V mutant was less stable than the active conformation of the mutant G89D and the ability to activate Gt...

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