... up-regulation of PDE1B2 upon mono-cyte-to-macrophage differentiation. Proc Natl Acad SciUSA 102, 497–502.16 Kaneda T, Watanabe A, Shimizu K, Urakawa N &Nakajyo S (2005) Effects of various ... GATCATGCACTGAAATTTA (2), GATGAAACCTCTCAAACTG (3), and CATCATCGCTGGACAATGT (4)], usingT. R. Dunkern and A. Hatzelmann Characterization of inhibitors of PDE1CFEBS Journal 274 (2007) 4812–4824 ª 2007 The Authors ... The day after seeding, cellswere transfected with 10 nm pan-PDE1C siRNA smart pool(Ambion Inc., Austin, TX, USA) [pool number M-007643–00, sequences CCAAGGAGATTGAAGAATT (1), GATCATGCACTGAAATTTA...