... after having a preliminary evaluation consisting of a brief medical history, smoking and alcohol habits and physical examinations. Inflammatory disease activity was defined as a Disease Activity ... oxidative activity in RA patients. Anti-CCP antibodies are directed against antigens containing the nonstandard amino acid citrulline, for example, citrullinated fibrin, which is found in the ... Arthritis (RA) is a chronic, inflam-matory, autoimmune, systemic disease, in which various joints in the body are inflamed, leading to swelling, pain, stiffness, and the possible loss of func-tion....