... the rate constants k A 0and kB0.Infact, the catalytic proton enhances the rate dramaticallyboth in the separated a and b chains, by a factor of morethan 106per mole for state A and state ... experimental data with the aid of a computer.As a result, the pH-dependence curves for the autoxidationrate of the separated a and b chains have been analysedcompletely in terms of an Ôacid-catalysed ... Shikama, PHP Laboratory for MolecularBiology, Nakayama-Yoshinari 1-16-8, Sendai 989-3203, Japan.E-mail: shikama@mail.cc.tohoku.ac.jpAbbreviations: Hb, haemoglobin; DPG, 2,3-diphosphoglyceric acid.Dedication:ThisreviewisdedicatedtoMaxF.Perutz(19...