... whichadenylic compounds may interact. We mutated three residues that mediateinteraction in the first activation site (R144, N154, I152) and three in thesecond (F127, M436 and H428), and found that ... cN-II, cN-III, cN-IA and cN-IB, and both cytosolic and mitochondrial 5¢(3¢)-deoxyribonu-cleotidases [5]. Even though all soluble 5 ¢-nucleotidasesshare the same reaction mechanism and possess con-served ... nucleotide hydrolysis and phosphate transfercatalysed by cN-II appear to be regulated by a numberof phosphorylated compounds such as ADP, ATP,BPG, Ap4A and polyphosphates. These compoundsact as...