... example,one of the most evident patterns in the amino- acid composition of hyperthermophilic proteins is the biasagainst thermally labile amino- acid residues. This pattern isobvious on examination of the ... [9,47–49]. Allthese studies reported a decrease in the content of unchargedpolar amino acids (i.e. Q, N, S, and T) and an increase incharged amino- acid residues (i.e. K, E, and R) inhyperthermophilic ... Oshima, T. (2001) Thermostabiliza-tion of a chimeric enzyme by residue substitutions: four amino acid residues in loop regions are responsible for the thermostability of Thermus thermophilus isopropylmalate...