Tài liệu Báo cáo khoa học: Parvalbumin deficiency in fast-twitch muscles leads to increased ‘slow-twitch type’ mitochondria, but does not affect the expression of fiber specific proteins doc

... compilation ª 2005 FEBS Parvalbumin deficiency in fast-twitch muscles leads to increased ‘slow-twitch type’ mitochondria, but does not affect the expression of fiber specific proteins Peter Racay*, Patrick ... Based on the twofold increase in mitochondrial volume in PV– ⁄ – fast-twitch muscles [6] we addressed the question of whether the profile of selected mitochondrial proteins corresponds to the one ... expression of fiber type specific MLC isoforms is not affected by PV deficiency, in line with previous findings that a lack of PV does not change the myosin heavy chain pattern[16]. Also, two cytosolic...

Tài liệu Báo cáo khoa học: RMI1 deﬁciency in mice protects from diet and genetic-induced obesity pptx

... describe here the phenotype of mutant mouse strain 0283. This strain exhibited aphenotype indicative of resistance to diet-induced andgenetic obesity. The mutation of the 0283 strain is in the RMI1 ... require further experiments. Increased energy intake also leads to an increase in the fat mass, which ultimately results in obesity. The deficiency in RMI1 significantly decreased the foodintake only ... vector to identify the trapped gene. Genomic DNA fragmentsflanking both the 5¢ and 3¢ ends of the integratedvector were obtained using the plasmid rescue method.Sequence analysis of this flanking...

Tài liệu Báo cáo khoa học: "Mapping Lexical Entries in a Verbs Database to WordNet Senses" doc

... majorityvote of the both of them (MajAggr) gives the bestresults of all. When they are joined by SemSim in Maj3Best, they continue to provide good results. The bottom line is that SemSim makes the mostsigniﬁcant ... the culling of the training set, sev-eral processes were undertaken that resulted in full mapping of entries in the lexical database to WordNet senses. Much, but not all, of this map-ping was ... weight equaling the sum of the group members’ weights. This variationalso adds to the vote total if the sense was as-signed in the training data. The Combo variationis like Triples, but rather than...

Tài liệu Báo cáo khoa học: "THEORETICAL/TECHNICAL ISSUES IN NATURAL LANGUAGE ACCESS TO DATABASES" pdf

... down into offices with which are associated the total numbers of employees employed therein, to total the values of the NUMBER -OF- EMPLOYEES field in all the records for offices in the sales ... .transformations TOTPUNIT and LOTINS2 do not apply; furthermore, the LOCATION transformation applies to the original instance of the verb LOCATED rather than the copy of LOCATED introduced by the lot insertion ... addi- tion to their zones. Translation to the form of set domain relational calculus used in TQA then provides a basis for either taking the initiative in automat- ically printing these implicitly...

Tài liệu Báo cáo khoa học: Vấn đề thưởng thức văn học nghệ thuật của công chúng hiện nay docx

... bd phan cdng chiing va ngay ehinh bd phan cdng chiing ay cung khdng d'n dinh. Dii sao di niia thi edng ehiing ciing dang quyet dinh hay gdp phan quyet dinh sir thanh edng ... tam chia edng ehiing thanh hai loai edng chiing nghe thuat: edng chiing tinh hoa va cdng chiing phd' thdng. Cdng chiing tinh hoa la nhiing ngudi am hie'u nghe thuat, hp dugc ... phan nd, hp nhin tha'y qua trinh sang tao am thim cua tac gii va ed the dat yeu cau vdi anh ta d qua trinh tie'p theo Cdn cdng ehiing phd' thdng, dd la nhiing ngudi yeu...

Tài liệu Báo cáo khoa học: Disulﬁde bridge regulates ligand-binding site selectivity in liver bile acid-binding proteins ppt

... T2values in the apoprotein and in all of the investigated holo proteins, thus plays a key role in regulating the positioning of the helix–loop–helix motif with respect to the b-barrel in order to ... cou-pled in different ways, whether in the presence or in the absence of the ligands [10]. Another source of ligand-binding variability may be introduced by the presence of disulﬁde bridges. Indeed, ... regulating these interactions is a key step in pro-viding a model for the transfer of BAs from the cyto-plasm to the nucleus for delivery to nuclear receptors,and can be used to inspire the design...

Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc

... might contribute to providing chromophore to melanopsin to maintaintheir light sensitivities. The expression and function of RPE65c in other cell types in the retina remains to beinvestigated.Earlier ... However, immunohistochemistry detected RPE65c in the inner retina,including Mu¨ller cells, but not in the RPE. Furthermore, double-immuno-staining of dissociated retinal cells using antibodies ... con-taining atRE (A), liposomes containing atRE in the presence of 1mM bipyridine (B) and liposomes containing atRE, in the presence of 1 mM bipyridine and 6 mM FeSO4(C). The generated retinoidswere...

Tài liệu Báo cáo khoa học: Applications and trends in systems biology in biochemistry docx

... computational modeling does not refer to statistical models or models of data mining but rather to a mathematical or ’virtual’ representation of the living system of interest in the computer, whereAbbreviationsFBA, ... strains showmarkedly different relative fluxcontributions (increased flux into the PPP and lysine biosynthesis,decreased flux into the TCA) at the same time as maintaining a constantsupply of ... 202–216.87 Choline,glycinebetainebiosynthesisNicotianatabacumImport of choline into the chloroplastis a major but not the only importantconstraint on glycine betainesynthesis. The regulation...

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... Conse-quently, the PH–TH domain doublet of ITK fusesdirectly with the linker B kinase region of SYK. The PH domain of TFKs usually binds to phosphatidylino-sitol-3,4,5-trisphosphate, thereby bringing them ... lymphoproliferative dis-ease. Arginine 335 is found in the ‘BG loop’ not involved in phosphotyrosine binding and mutation to tryptophan most probably causes instability of the SH2 domain. Thus, these patients ... constitutes the second largest family of cyto-plasmic tyrosine kinases. In 1993, loss -of- function mutations in the BTKgene were reported as the cause of X-linked agammaglobulinemia. Of all the existing...

Tài liệu Báo cáo khoa học: Solution properties of full-length integrin aIIbb3 reﬁned models suggest environment-dependent induction of alternative bent ⁄extended resting states doc

... shown in Fig. 3A–D. The C-terminalregion of the models’ ectodomains, including the mod-eled E764-D774 and G840-Q873 loops, the attachment of the ectodomain to the TM helices, and the inter-faces ... back the I-EGF3-4 and bTD domains by $ 29° along the C473-C503 hinge, and then performing a slight rotation of the bTD module at the main chain of D606 to dock itagainst the calf-2 domain with ... removed to make space for the TM helices of the integrins, either from the center of the nanodisc or close to the protein belt, to take intoaccount possible effects of the high gravitational ﬁeldReﬁned...

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