Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
... 2007 The Authors Journal compilation ª 2007 FEBS 4121 Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin- binding ... a novel G -actin- binding domain, which we call a verprolin homology 2 C-terminal (VH2-C) domain; and a second submod-ule comprising the Las17p- binding domain (LBD) that binds Las17p (yeast WASP). ... N-terminal or VH2-N)which we previously showed does contain an actin- binding domain (this actin- binding domain has not yetbeen mapped) [23]. We name the actin- binding domain that we have identified...
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Tài liệu Báo cáo khoa học: Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11⁄hippostasin ppt
... the artifact may be caused by using a planttranslation system, in which mammalian mRNA wasinappropriately translated. The transient expressionassay indicated that M33S and isoform 1 proteinswere ... 5¢-TCATGCTGGTTGAGACTGGA-3¢ and 5¢-CCAGGTGTGGAGCAAGGCAG-3¢) and a 938 bp fragment of promoter 3 (primers, 5¢-CTCACAGCAGCCAGTAAGTG-3¢ and 5¢-ACTCACAGGCTCTGGGGCTG-3¢) were amplified using a Taq ... saliv-ary glands. In vitro mutagenesis revealed that the initiation codon for iso-form 2 in exon 1b was functional. Isoform 2 had additional hydrophilicamino acids at the amino terminal and...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... [53].Role of the TXT motif and water in activityExamination of the crystal structures of the insect AFPsalso revealed the presence of an array of water moleculesFig. 4. Comparison of the insect ... that TmAFP has o ne and a h alfextra coils along the T XT face (Fig. 8A) . This gives TmAFPone and a half additional TXT motifs along the ice-bindingface, though the C-terminal motif contains ... and Protein Engineering Network of Centres of Excellence, University of Alberta, Edmonton, Alberta, CanadaAntifreeze proteins (AFPs) designate a class of proteins thatare a ble to bind to and...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... com-posed of an extracellular ligand-binding domain, a transmembrane domain and an intracellular tyrosinekinase domain. The binding of a ligand to the extracel-lular domain of the EGFR induces ... dimeriza-tion, activation of the intracellular kinase domain and autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptor. The tyrosine-phosphorylated motifs of the ... However, the Akt pathway plays a minor role in the induction of apoptosis in intestinal epithelial cells. Instead, p38MAPK phosphorylation is associated with mitochon-drial translocation of Bax and...
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Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... control. The targetmRNA was normalized against actin in the same sample. The PCR primers were as follows: actin forward, 5¢-GAAATCGTGCGTGACATCAAAG-3¢; actin reverse, 5¢-TGTAGTTTCATGGA TGCCACAG-3¢; ... proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptoticpathwayYuanyuan Xiao, Taichang Yuan, Wenqi Yao and Kan LiaoState Key Laboratory of Molecular Biology, Institute ... 693TTTTTCAGTGCAGAA-3¢; aP2 forward, 5¢-AAAGACAGCTCCTCCTCGAAGGTT-3¢; and aP2 reverse, 5¢-TGACCAAATCCCCATTTACGC-3¢. Standard curves were gen-erated with 10-fold serial dilutions ranging from...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... (GRASP55). Further analysis revealed that GRASP55 associated with the cytoplasmic domain of both proteases and that the LLY573motif in the MT1-MMP intracellular domain was crucial for the interaction ... for furin-mediated activation of transmem-brane substrates. The activation of ADAM17 by furin[68] and our observation of an interaction betweenGRASP55 and the ICD of ADAM17 (C. Roghi and L. ... 3169MT1-MMP and furin can interact with GRASP55.Overexpression of GRASP55 has been found toincrease the amount of complex containing MT1-MMP and furin, and the expression of a catalyticallyinactive...
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Tài liệu Báo cáo khoa học: How disorder influences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx
... N-terminalhexahistidine tag was obtained by PCR using the pET2 1a ⁄ PNT-H6plasmid [30] as the template. The forwardprimer (5¢-TACCGTTAACATCGATATGCATCATCATCATCATCATGC-3¢) was designed to insert ... ZhangX, Buccellato M, Darbon H, Canard B, Finet S &Longhi S (2005) The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of ... M, Takeda M, Shirogane Y, Nakatsu Y,Nakamura T & Yanagi Y (2009) The matrix protein of measles virus regulates viral RNA synthesis and assembly by interacting with the nucleocapsid protein.J...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf
... beta- and gamma-catenins in their cytoplamic tails. As with tightjunctions, adherens junctions are linked to the actin cytoskeleton via the binding of beta- and gamma-cate-nin to alpha-catenin ... vas-culature, because they regulate the formation and main-tenance of BBB, modulate neurovascular coupling and maintain several parts of brain homeostasis. In thisminireview, we focus on the active functions ... that astrocytes play active roles in various brainfunctions. In particular, astrocytes function as adultneural stem cells, participate in the formation and mod-ulation of synapses, and in the...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc
... of Fundamental Research in Health Science’ of the Organi-zation for Pharmaceutical Safety and Research. In May2009, the FDA in the USA approved bevacizumab for the treatment of patients with relapsed ... astrocytes, and the tight junctions of vascular endothelial cells (ECs) in the BBB are well organized with claudins and ZO-proteins through a decrease in angiogenesis signaling and an increase in the ... similar to the tumor-associatedmacrophages reported by several groups [28].Glioma metastasis and VEGFIntracranial invasion and metastasis are major prob-lems in the prognosis of malignant...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx
... Rosell A, Alvarez-Sabin J, Arenillas JF, Rovira A, Del-gado P, Fernandez-Cadenas I, Penalba A, Molina CA& Montaner J (2005) A matrix metalloproteinase pro-tein array reveals a strong relation ... The transla-tional attractiveness of this approach lies in the factthat minocycline can be easily used in humans.Taken together, the accumulating experimental and clinical data suggest that MMPs ... excitotoxicity has beenthought of as the main reason for neuronal cell death.Although NMDA receptor activation in the acutephase leads to neuronal damage, the same NMDA sig-naling may participate in neurovascular...
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