Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf

... (1999) S100A4 involvement in metastasis: deregula-tion of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti -S100A4 ribozyme. ... cysteine-rich protein with kazal motifs (RECK) is a cell mem-brane associated inhibitor of MMP-2 that is able toinhibit the second activation step of MMP-2 [9].The small calcium-binding protein ... Yean TD, Lu HS, Ting J & Langley KE(1991) Inhibition of autoproteolytic activation of inter-stitial procollagenase by recombinant metalloproteinaseinhibitor MI ⁄ TIMP-2. J Biol Chem 266,...

Tài liệu Báo cáo khoa học: "Using adaptor grammars to identify synergies in the unsupervised acquisition of linguistic structure" docx

... interaction in learning several aspects of linguistic structure si-multaneously, as compared to learning each kind of linguistic structure independently.Because learning collocations and word-initialsyllable ... inferenceprocedure is that it gives us a way of learning theseinteracting linguistic structures simultaneously.Adaptor grammars are also interesting becausethey can be viewed as directly inferring linguisticstructure. ... construct an in nite number of more specialized PCFGs by splitting or reﬁning thePCFG’s nonterminals into increasingly ﬁner states;this leads to the iPCFG or in nite PCFG” (Liang etal., 2007)....

Tài liệu Báo cáo khoa học: Type I antifreeze proteins expressed in snailﬁsh skin are identical to their plasma counterparts doc

... all fishexamined had significant levels of protein in blood andskin during the winter. It is possible that different phy-siological or environmental cues initiate expression in each tissue separately. ... solutionfreezing point noncolligatively by binding to certainsurfaces of ice crystals, modifying their structure andinhibiting further growth. The difference between thelowered freezing point and ... proteins that are identical to circulating plasmaAFPs. Although all fish examined consistently express antifreeze mRNA in skin tissue, there is extreme individual variation in liver expression...

Tài liệu Báo cáo khoa học: Chromatin under mechanical stress: from single 30 nm ﬁbers to single nucleosomes pdf

... compaction level of native chromatin fibers (containing the linker histone)is significantly higher in 150 mm NaCl than in 40 mm[9], quite surprisingly the experiments in 150 mm didnot show significant ... interaction, typically usingbiotin ⁄ streptavidin or digoxigenin ⁄ anti-digoxigenincoupling between the fiber ends and beads.Four distinct types of chromatin substrates havebeen used for stretching ... release of the outer DNA turn’ [41] is verysimilar to the initial plateau in the experiments withnative chromatin under similar ionic conditions [37],interpreted as chromatin fiber accordion-like...

Tài liệu Báo cáo khoa học: Secondary substrate binding strongly affects activity and binding afﬁnity of Bacillus subtilis and Aspergillus niger GH11 xylanases docx

... be an important residue for theSBS. The screening ratio of D32A is similar to that of the wild-type, indicating the minor importance of theacidic side chain of Asp32. This result is logicalbecause ... Vandermarliere et al. [12]. Amino acid residues that form direct protein–ligandinteractions with their main chain only are indicated by an asterisk.S. Cuyvers et al. Secondary substrate binding in ... resultsobtained in the previous screening experiment directlyTable 1. The effect of genetic engineering of the secondary bind-ing site of the B. subtilis and A. niger xylanases on the screeningratio....

Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in ﬁsh pdf

... expression was only slowly inhibited[45], indicating that a reduced permissive amount of Dmrt1 expression might not be totally incompatiblewith active ovarian differentiation. In addition, in pejerrey, ... Testis Decreases duringtesticular involutionn .i. PCR [31]Silurus meridionalis G Ovary and testis High in testes duringmasculinizationn .i. PCR [29]Takifugu rubripes G Testis and ovary High in ... (DM)domain. Being a noncanonical cysteine-rich DNA-binding motif, this domain has two highly intertwinedﬁnger structures that chelate one zinc ion each, andbinds to the minor groove of the...

Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf

... lesionsby EHEC by recruiting a-catenin, a cytoskeletal pro-tein that recognizes actin, to the site of bacterial con-tact [65,66]. In addition, it is also involved in theinhibition of myosin ... induc-tion. Salmonella SipC carries two functions: participa-tion in the formation of the membrane-inserted poreand acting as an actin nucleation initiator by promot-ing its own multimerization ... apparatus isa hydrophilic protein: PcrV in P. aeruginosa, LcrV in Yersinia spp, IpaD in Shigella and SipD in Salmonellaspp (Fig. 2). The LcrV protein of Yersinia pestis wasdiscovered more than...

Tài liệu Báo cáo khoa học: Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy pdf

... theincreased reactivity in COS-7 cells but not in E. coli(Fig. 2C,D). In addition, an immunocytochemicalstudy of COS-7 cells expressing ATN1s showed anapparent increase in the immunoreactivity ... anti-rabbit IgGwas used as secondary antibodies. Nuclei of cells werevisualized by staining with 4¢-6-diamidino-2-phenylindole.Preparation of human brain tissue samplesPost-mortem brain tissue ... features characterizing DRPLA are cytoplasmicinclusions, which are immunoreactive to ubiquitin andATN1 antibodies, and also include nuclear inclusions in the DRPLA brains [2,26]. In the present...

Tài liệu Báo cáo khoa học :Phương ngữ Thánh Hóa với việc phát triển văn hóa du lịch pdf

... NGHIEN CUU - TRAO OOI PIIlIONG \GlJ THANH HOA Vdi VIEC PHAT TRIEN VAN IIOA, DC LICH TS. Hoang Minh Ti/dng Phd Giam doc So Thong tin va Truyen thong Thanh ... thdi cung la Kinh do cua cac vddng trieu trong lich sd. Chinh dat kinh ky ay da dem den cho xd Thanh sd anh hddng va tiep can vdi van hoa, ngon ngd cua cac thdi dai phong kien ... Chdi beu may, nghia tieng phd thdng la Trdi day doa may; "may" gpi la "mi": mi di mo ve da, nghia la: may di dau ve day Tieng Thanh la phddng ngd cd Viet -Mddng in...

Tài liệu Báo cáo khoa học: Hsp105b upregulates hsp70 gene expression through signal transducer and activator of transcription-3 pdf

... levels of a series of C-terminal deletion mutants of Hsp105b and a-tubulin were determined by western blotting using antibod-ies against myc-tag and a-tubulin, respectively. Relative activity is ... exists in an inactive form as a monomer; in response to stress,it forms homotrimers that bind to the HSEs in thepromoter regions of hsp genes [19]. In addition, an in ammatory cytokine, interleukin-6, ... fractions were washed ﬁve times withbinding buffer, and DNA-bound proteins were eluted withbinding buffer containing 1 mgÆmL)1biotin; this was fol-lowed by SDS ⁄ PAGE and western blotting.Chromatin...

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