... studied and is the best charac-terized member of the family. In addition to its kinasedomain, Mst1 contains an inhibitory domain, deletion of which results in increased kinase activity, and a ... Drosophila inhibitor of apoptosis I; GCK, germinal center kinase; HA, hemagglutinin; Hpo, serine/threonine kinase Hippo; IL-2,interleukin-2; Lats, large tumour suppressor; MBP, myelin basic protein; ... Mst.Mst:Salvador:Δ433WTΔ374Δ344Δ321Δ268Δ199WT199-383268-383321-383kinase domaininhibitorydomaincoiled-coildomainWW domainscoiled-coildomainFig. 2. The structure of Mst kinase and hSalvador. Schematic illustrations of Mstkinase and hSalvador...