... Establishment of Project Implementation Units; involvement of Consultants Review of Procurement Proceduresand Evaluation Process Identification of Implementation Difficulties and Remedial Measures ... Tariff level and structure Product quality PROJECT (stage of development at the time of appraisal varies) Technology and Design Co-lender's requirements Time schedule Viability and performance ... securities Local and foreign currencies Phasing of expenditure Margins for var.contingencies Cost justification Market prospects Procurement Demand pattern Techn.characterist. /procedures Degree of competition...
... mutations Out of a total of 12 constructs (E21K, E21Q, D31K, D31N, E34K, E35K, E34K/ Page of E35K, F99K, F99N, F99Q, F99H, F99A), none of them reversed the inhibitory effect of H69E on protease ... properties of surface residue 69 J Virol 20 09, 83(15):77 89- 7 793 34 Louis JM, Clore GM, Gronenborn AM: Autoprocessing of HIV-1 protease is tightly coupled to protein folding Nat Struct Biol 199 9, 6:868-875 ... point Page of mutations between NL4-3 and wtpse protease, our data suggested that the inhibitory effect of H69E on protease autoprocessing is influenced by other residues C95 andother residues...
... crescentus andother alpha-proteobacteria J Bacteriol 2003, 185: 499 7-5002 Soukup GA, Breaker RR: Relationship between internucleotide linkage geometry and the stability of RNA RNA 199 9, 5:1308-1325 ... 2002, 99 :1 590 8-1 591 3 Mandal M, Boese B, Barrick JE, Winkler WC, Breaker RR: Riboswitches control fundamental biochemical pathways in Bacillus subtilis andother bacteria Cell 2003, 113:577-586 Mandal ... 5' end In-line probing of an RNA corresponding to a portion of one A tumefaciens intergenic region containing this motif (GenBank:NC_003305.1; nucleotides 97 9721 to 97 9 594 ) also indicates that...
... companies In Finland, Honko and Virtanen ( 197 5), Virtanen ( 198 4), and most recently Keloharju and Puttonen ( 199 5) have surveyed the investment evaluation criteria and planning horizon of Finnish publicly ... one of the methods In 199 4, more than 43 percent of the companies mentioned ROI as one of their evaluation methods In our study, we did not have ROI as INVESTMENT EVALUATION METHODSAND one of ... 75.7 % 22.7 % 74 .9 % 52.3 % 046 (92 %) 046 (92 %) 036 ( 59 %) 104 (46 %) 046 (32 %) 392 0 (9 %) 1 29 (24 %) Table summaries the overall development in Finland according to the results of past studies...
... (Pettinato and Stephanou, 198 9) The kinematics of grasping is discussed in Chapter The basic kinematic structure of a multifingered hand consists of a palm, which plays the role of the base of a simple ... and University of Toronto, among TLFeBOOK 12 An Overview of Robotic Mechanical Systems FIGURE 1.8 The four-fingered hydraulically actuated TU Munich Hand (courtesy of Prof F Pfeiffer.) others Of ... these, the Utah/MIT Hand (Jacobsen et al., 198 4; 198 6) is commercially available It consists of four fingers, one of which is opposed to the other three and hence, plays the role of the human thumb...
... 6.7 Incorporation of Gravity Into the Dynamics Equations 6.8 The Modeling of Dissipative Forces 1 89 1 89 190 192 192 196 199 201 202 211 211 211 213 213 ... Borgne, and Espiau ( 199 1) and, at a more introductory level, of Spong and Vidyasagar ( 198 9) TLFeBOOK 1.2 The General Structure of Robotic Mechanical Systems FIGURE 1.2 Block diagram of a general ... Axes 3.7 Static Analysis of Rigid Bodies 3.8 Dynamics of Rigid Bodies 71 71 72 74 76 80 83 84 85 88 91 93 95 99 Kinetostatics of Simple Robotic Manipulators...
... 15 Fersht A ( 199 9) Structure and Mechanism in Protein Science – A Guide to Enzyme Catalysis and Protein Folding, 2nd edn W.H Freeman and Company, New York, NY 16 Zimmermann H ( 199 2) 5¢-nucleotidase: ... structure of cN-II showing interfaces A and B and the Mg2+ site The inset shows the tertiary structure of each subunit Effector sites andand the active site are shown Table Effect of point mutations ... profiles of wild-type cN-II alone (A), or in the presence of mM ATP and 10 mM MgCl2 (B), or in the presence of mM Pi and 10 mM MgCl2 (C) The column, prepared and eluted as described in Experimental procedures, ...
... Korenbrot, J.I & Miller, D.L ( 198 9) Cytoplasmic free calcium concentration in dark-adapted retinal rod outer segments Vision Res 29, 93 9 94 8 29 Gray-Keller, M.P & Detwiler, P.B ( 199 4) The calcium feedback ... Hunt, D.M & Hurley, J.B ( 199 9) Biochemical analysis of a dimerization domain mutation in RetGC-1 associated with dominant cone-rod dystrophy Proc Natl Acad Sci USA 96 , 90 39 90 44 16 Duda, T., Venkataraman, ... function of the substrate GTP We used Mg2+ as cofactor and kept the ratio of Mg2+ to GTP at : Analysis of data was performed with ORIGIN 6.1 and SIGMA PLOT 4.2 software A direct plot of activity...
... Summary of Disallowances and Categorization of Findings Funds Diverted to Personal Use Funds Used for Unallowable Items $5,044,373 $7 ,94 8,885 1 $21,555 $2 39, 8 89 $646,066 $617,1 09 $94 8,536 $2,524 ,99 1 ... possible professional discipline, primarily as a result of recent OSC audits To date, RSU staff has referred eight CPAs to the Office of the Professions for investigation Office of the Professions ... by the Office of Alcoholism and Substance Abuse Services (OASAS), the Office of Mental Health (OMH) and/ or the Office for People With Developmental Disabilities (OPWDD) Representatives of these...
... V[model-TnC(1 91 )–TnI (98 –147)] ⁄ V(1SKT) and MM [TnC(1 91 )–TnI (98 –147)] ⁄ mm(1SKT); and (c) V[modelTnC(1 91 )–TnI (98 –182)] ⁄ V(model-TnC(1 91 )–TnI (98 – 147)] and MM[TnC(1 91 )–TnI (98 –182)] ⁄ mm[TnC (1 91 )–TnI (98 –147)] If the ... function of the modulus of the scattering vector q are shown for TnC(1 91 )–TnI (98 –182) (Fig 4A) and TnC(1 91 )–TnI (98 –147) (Fig 4B) The value of the radius of gyration obtained for TnC(1– ˚ 91 )–TnI (98 –182) ... TnC(1 91 )–TnI (98 –182) and TnC(1 91 )–TnI (98 –147), were cloned into pET3a vector digested with NdeI and BamHI creating the respective vectors pET3aTnC(1 91 )–TnI (98 –182) and pET3aTnC(1– 91 )–TnI (98 –147)...
... displacement of the cofactor results in a loss of stabilizing hydrogen bonds between O1Â and O2Â of the dihydroxypropyl side-chain and Ser23O in the autoregulatory sequence (Fig 4C and Table 1) and thus ... Control of catalysis by (6R)tetrahydrobiopterin and phenylalanine J Biol Chem 2 69, 24657 24665 12 Dứskeland, A.P., Dứskeland, S.O., ỉgreid, D & Flatmark, T ( 198 4) The eect of ligands of phenylalanine ... host cell proteases Isolation and characterization of the wild-type enzyme Biochem J 306, 5 895 97 24 Roskoski, R Jr ( 198 3) Assays of protein kinase Methods Enzymol 99 , 36 25 Flatmark, T., Almas,...
... point to accelerated ice losses since 199 3 ranging from about 60 percent ( 199 3 to 199 8; Krabill et al., 2004) to a threefold increase ( 199 3 to 199 8 relative to 199 8 to 2004; Thomas et al., 2006) RESTRUCTURING ... understanding of the climate system and the creation of a robust observations and modeling infrastructure However, the paucity of social science research and the separation of natural and social ... and thresholds and barriers to adaptation), of economic costs and SUMMARY dynamics, andof human behaviors, policy preferences, and choices; and on assumptions about the future availability of...
... Management and Enforcement Technology: Europe and Australia ( 199 6) Pedestrian and Bicycle Safety in England, Germany, and the Netherlands ( 199 4) Planning and Environment Managing Travel Demand: Applying ... Bridges in Europe and Japan ( 199 7) Asian Bridge Structures ( 199 7) Bridge Maintenance Coatings ( 199 7) Northumberland Strait Crossing Project ( 199 6) European Bridge Structures ( 199 5) Contents Executive ... Control Technology and Practice in Europe ( 199 9) European Winter Service Technology ( 199 8) Traffic Management and Traveler Information Systems ( 199 7) European Traffic Monitoring ( 199 7) Highway/Commercial...
... 16, 3 79 3 89 Murphy G & Crabbe T ( 199 5) Gelatinases A and B Methods Enzymol 248, 470–484 Bode W, Fernandez-Catalan C, Tschesche H, Grams F, Nagase H & Maskos K ( 199 9) Structural properties of matrix ... 104, 99 1 99 9 Pourmotabbed T, Solomon TL, Hasty KA & Mainardi CL ( 199 4) Characteristics of 92 kDa type IV collagenase ⁄ gelatinase produced by granulocytic leukemia cells: structure, expression of ... Quantification of matrix metalloproteinases in tissue samples Methods Enzymol 248, 510–528 MMP -9 activity against collagens I and III 49 Koshy PJT, Rowan AD, Life PF & Cawston TE ( 199 9) 96 -Well plate...
... that the RIIa regulatory subunit of PKA is expressed anywhere other than the cytosol and the cytoplasmic surfaces of membranes [ 29] On the other hand accurate subcellular distribution of HIP/PAP ... substrate in the presence or absence of lM 8-bromo cAMP and 100 lM PKI, in two clones of Chang cells stably expressing HIP/PAP (called HIP9 and HIP4) and two clones of Chang cells stably transfected ... cloning and expression in pancreatic diseases J Clin Invest 90 , 2284–2 291 Drickamer, K ( 199 3) Recognition of complex carbohydrates by Ca2+-dependent animal lectins Biochem Soc Trans 21, 456– 4 59 Christa,...
... Vilcek, J ( 198 9b) Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways Proc Natl Acad Sci USA 86, 99 36 99 40 18 Burke, ... amount of transcription factors used in (A), with or without lg of IRF-1 or of an IRF3/7 mix and 0.75 lg of CBP; 4X, 2X and 1X correspond to decrease of the amount used in 8X by factors of 2, and ... and C2-regions of p300, and to the N- and C2-regions of CBP Thus, the bulk of the interaction between NF-jB and p300/CBP is mediated by the p65 subunit through the N- and C-terminal regions of...