yqjdg on anti nasopharyngeal carcinoma npc

Studies of the anti cancer potential of flavonoids in human nasopharyngeal carcinoma cells

Ngày tải lên : 10/09/2015, 15:53

... flavonoids and their bioavailability Anti- oxidant activity of flavonoids Anti- oestrogenic (and oestrogenic) activity of flavonoids Anti- tumour property of flavonoids Effects of flavonoids on NF-B ... 1.6.1 Cancer Introduction Cancer initiation and progression Alterations in cancer genomes and signal transduction Nasopharyngeal carcinoma Cell cycle Cdks and their corresponding cyclins as the ... flavonoids on NF-B Effects of flavonoids on cell cycle Effects of flavonoids on Akt Effects of flavonoids on tumour suppressor p53 Activation of apoptosis by flavonoids Quercetin Luteolin Objective...

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Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma Edited by Shih-Shun Chen pptx

Ngày tải lên : 23/03/2014, 17:20

... Nasopharyngeal Carcinoma DNA methylation, histone modifications and chromatin structure DNA methylation is the only genetically programmed DNA modification in mammals This postreplication modification is ... by histone kinases (HKs) Other histone modifications include attachment of ubiquitination, and sulmolation Enzymes responsible for the cleavage of some histone modifications, such as histone deacetylases ... hypermethylated not only in NPC, but also in esophageal and cervical carcinomas Downregulation of DLC1 contributes to NPC oncogenesis by disrupting Epigenetics of Nasopharyngeal Carcinoma Ras-mediated...

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báo cáo hóa học:" Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin" docx

Ngày tải lên : 18/06/2014, 15:20

... Journal of Translational Medicine 2008, 6:55 http://www.translational-medicine.com/content/6/1/55 Background Methods Nasopharyngeal carcinoma (NPC) is a common malignant epithelial tumor ... neck squamous cell carcinoma, ovarian carcinoma, hepatoma, and so on, the expression of ABCC2 has also been found [11,12] However, little research on the expression of ABCC2 in NPC cell lines has ... from this calibration curve was y = 1.59x + 17.917(y stands for peak height of cisplatin and x stands for concentration of cisplatin) Based on this equation, the concentration of cisplatin for...

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báo cáo hóa học:" ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway" pot

Ngày tải lên : 18/06/2014, 15:20

... relative to the control (DMSO treated cells, DMSO concentration was less than 0.1%) was plotted as a linear function of the drug concentration The antiproliferative effect of ApoG2 on NPC cells was ... inhibitory concentration of ApoG2 was defined as the concentration of the drug required to achieve 50% growth inhibition relative to control populations Cell Cycle Analysis Untreated control and ApoG2-treated ... c-Myc protein; the reduction in c-Myc expression led to upregulation of p21 expression and downregulation of cyclin D expression Cell cycle analysis showed that incubation with scrambled siRNA...

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báo cáo hóa học:" Reliability of 95% confidence interval revealed by expected quality-of-life scores: an example of nasopharyngeal carcinoma patients after radiotherapy using EORTC QLQ-C 30" pdf

Ngày tải lên : 20/06/2014, 16:20

... checking non-overlapping 95% confidence intervals (CIs) Limitations of the study We simulated data from 115 patients newly diagnosed with nasopharyngeal carcinoma who responded to the 28 questions on ... Additional file Author-made A Excel-VBA module computing test Cronbach's α, item/person skewness coefficient and person expected response score Excel-VBA routine of a calculation demonstration for ... 1996, 20:101-125 19 Macdonald P, Paunonen SV: A monte carlo comparison of item and person statistics based on item response theory versus classical test theory Educational and Psychological Measurement...

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Guidelines on - Renal Cell Carcinoma potx

Ngày tải lên : 06/08/2014, 17:21

... 6.5.1 Conclusion 6.5.2 Recommendation 6.6 Resection of metastases 6.6.1 Conclusion 6.6.2 Recommendation 6.7 Radiotherapy for metastases in RCC 6.7.1 Conclusion 6.7.2 Recommendation 6.8 References ... 7.1.1 Conclusion 7.2 Immunotherapy 7.2.1 Interferon-alpha monotherapy and combined with bevacizumab 7.2.1.1 Conclusions 7.2.2 Interleukin-2 7.2.2.1 Conclusions 7.2.2.2 Recommendations 7.3 ... approaches 6.3.2.1 Radiofrequency ablation and cryoablation 6.3.2.2 Conclusions 6.3.2.3 Recommendations 6.4 Adjuvant therapy 6.4.1 Conclusion 6.4.2 Recommendation 6.5 Surgical treatment of metastatic...

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Báo cáo khoa học: "Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia" docx

Ngày tải lên : 09/08/2014, 07:21

... the amplicons from NPC tissues spanning the LMP1 C-terminal region, namely NPC1 and NPC2 was determined In addition to the 30-bp deletion, NPC2 but not NPC1 harboured a mutation at codon 335 This ... investigation Conclusion In conclusion, LMP1 30-bp deletion and loss of XhoI site was found in NPC tissues but not non-malignant tissues Dual variants of LMP1 were only found in plasma from NPC patients ... mutations [11] Deletion of a 30-bp sequence in the LMP1 gene results in progression from a non-oncogenic to an oncogenic state Restoration of the 30-bp sequence reversed the transformation ability...

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Báo cáo khoa học: "SemiClinical application of tumor volume in advanced nasopharyngeal carcinoma to predict outcome" pptx

Ngày tải lên : 09/08/2014, 08:22

... mm sections Direct coronal scans also were taken to provide auxiliary information One hundred millimeters of contrast medium were administrated with an injection rate between mL per second and ... protocol consisted of monthly cycles of cisplatin (100 mg/m2/day) on Day followed by 5-FU (1000 mg/m /day) continuously infused for consecutive days, in the presence of adequate hydration and anti- emetic ... Lai M, Kwan WH, Choi P, Johnson PJ: Concurrent chemotherapyradiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: progression-free survival analysis of...

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Báo cáo khoa học: "Validation of bidimensional measurement in nasopharyngeal carcinoma" ppsx

Ngày tải lên : 09/08/2014, 09:20

... predict outcome Radiat Oncol 2010, 5:20 doi:10.1186/1748-717X-5-72 Cite this article as: Chang et al.: Validation of bidimensional measurement in nasopharyngeal carcinoma Radiation Oncology 2010 5:72 ... take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus ... Chu NM, et al: A prognostic scoring system for locoregional control in nasopharyngeal carcinoma following conformal radiotherapy Int J Radiat Oncol Biol Phys 2006, 66:992-1003 Sze WM, Lee AW, Yau...

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Báo cáo khoa học: "3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma" pot

Ngày tải lên : 09/08/2014, 09:20

... SK O, Kwong D, Yau TK, Law SC, Sze WK, Au G, Chan AT: Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma ... significantly enhances local control of early T-stage nasopharyngeal carcinoma: the existence of a dose-tumor-control relationship above conventional tumoricidal dose Int J Radiat Oncol Biol Phys 2000, ... tumor control after primary radical radiotherapy in 903 non-disseminated nasopharyngeal carcinoma patients Clin Oncol (R Coll Radiol) 1996, 8:160-6 Leung TW, Tung SY, Wong VY, Sze WK, Lui CM, Wong...

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Báo cáo khoa học: "Survival rate in nasopharyngeal carcinoma improved by high caseload volume: a nationwide population-based study in Taiwan" docx

Ngày tải lên : 09/08/2014, 09:20

... up in a team consisting of otolaryngologist, radiation oncologists, hematology oncologists, and radiologists, the cornerstone of treatment of NPC relied on the successful eradication of disease ... take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus ... radiotherapy on NPC survival, we calculated the caseload volume of radiation oncologists In agreement with previous volume-outcome studies, our results indicated that increased caseload of radiation oncologists...

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Báo cáo khoa học: "Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma" docx

Ngày tải lên : 09/08/2014, 09:21

... Abbreviations: CTCAE v3.0: the Common Terminology Criteria for Adverse Events, version 3.0 IC: induction chemotherapy (IC); CCRT: concurrent chemoradiation Shueng et al Radiation Oncology 2011, ... A study conducted in Hong Kong [18] reported that 24/25 locally advanced NPC patients achieved partial remissions after induction chemotherapy Additionally, the 3-year local-PF, regionalPF, and ... Glisson B, Xia P, Bosch W, Morrison WH, Quivey J, Thorstad W, Jones C, Ang KK: Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology...

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Báo cáo khoa học: "Prognosticators and Risk Grouping in Patients with Lung Metastasis from Nasopharyngeal Carcinoma: A more accurate and appropriate assessment of prognosis" doc

Ngày tải lên : 09/08/2014, 09:21

... several parts Only considered LMS was contrasted to the point that DM originated from occult dissemination at the first Cao et al Radiation Oncology 2011, 6:104 http://www.ro-journal.com/content/6/1/104 ... Nasopharyngeal carcinoma Lancet 2005, 365:2041-2054 Marks JE, Phillips JL, Menck HR: The National Cancer Data Base report on the relationship of race and national origin to the histology of nasopharyngeal ... 56:351-361 Husband JE, Reznek RH: Imaging in oncology edition London: Taylor & Francis; 2004 Buthiau D, Khayat D: CT and MRI in oncology Berlin; London: Springer; 1998 Lin JC, Jan JS, Hsu CY, Liang...

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Báo cáo khoa học: "Radiation Induced Temporal Lobe Necrosis in Patients with Nasopharyngeal Carcinoma: a Review of New Avenues in Its Management" doc

Ngày tải lên : 09/08/2014, 09:21

... provide additional information about the lesions Perfusion and diffusion weighted MRI Perfusion MRI allows a non-invasive evaluation of cerebral blood flow (CBF) and relative regional cerebral ... findings on conventional imaging Yet, the lack of specificity of conventional imaging has prompted the search for a more reliable diagnostic tool DIAGNOSTIC MODALITIES Conventional imaging Among the ... treated with conventional 2D radiotherapy rather than 3D or IMRT An incidence of TLN of 4.6% in 10 years (conventional fractionation)[4] to 35% in 3.5 years (accelerated fractionation to 71.2 Gy...

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Báo cáo khoa học: " Intensity-modulated radiotherapy of nasopharyngeal carcinoma: a comparative treatment planning study of photons and protons" pps

Ngày tải lên : 09/08/2014, 09:22

... systems, CT scanner on rails, or functional treatment verification imaging based on the reconstruction of positron emission tomography signals derived from the http://www.ro-journal.com/content/3/1/4 ... application of Image-guided proton therapy (IGPT) during the course of the treatment Based on the acquired information, both correction for the daily deviations of the target position and modifications ... randomized study (NPC- 9902 Trial) on therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally advanced nasopharyngeal carcinoma Int J Radiat Oncol Biol Phys 2006,...

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Báo cáo khoa học: "Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: analysis of data rom randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01)" pdf

Ngày tải lên : 09/08/2014, 10:20

... Radiation Oncology 2009, 4:23 Introduction Nasopharyngeal carcinoma (NPC) is the sixth most common male cancer in Singapore The current standard of care for locally advanced NPC is concurrent ... breastconserving surgery and radiation Int J Radiat Oncol Biol Phys 2008, 71:1006-13 Wee J, Tan EH, Tai BC, Wong HB, Leong SS, Tan T, Chua ET, Yang E, Lee KM, Fong KW, Tan HS, Lee KS, Loong S, ... Treatment 0.647 Abbreviations: COX-2, cyclooxygenase-2; IHC, immunohistochemistry; RT, radiation; CRT, chemo-radiation Page of (page number not for citation purposes) Radiation Oncology 2009, 4:23...

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Báo cáo y học: " High cell density and latent membrane protein 1 expression induce cleavage of the mixed lineage leukemia gene at 11q23 in nasopharyngeal carcinoma cell line" ppt

Ngày tải lên : 10/08/2014, 05:21

... Expression of LMP1 gene induces DNA breaks within the MLL bcr Expression of LMP1 gene was confirmed by Western blotting using anti- V5 (Fig 4A) and S12 anti- LMP1 antibody (Fig 4B) Expression was demonstrated ... expression plasmids, pcDNA-LMP1 or pTracer-LMP1 (lanes and 4) Cell lysate was analyzed on 10% SDS PAGE, and LMP1 expression was detected by anti- V5 antibody (B) Detection with S12 anti- LMP1 antibody ... take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus...

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Báo cáo y học: "Extra-cellular release and blood diffusion of BART viral micro-RNAs produced by EBV-infected nasopharyngeal carcinoma cells" pps

Ngày tải lên : 12/08/2014, 01:22

... information about the tumor phenotype Additional investigations will be required on patient plasma samples - both NPC and controls - in order to address questions: 1) Are concentrations of BART ... donors are summarized in Table All five NPC patients had positive EBER-staining on tissue sections from their tumors Two control patients were bearing non -NPC epithelial tumors: HEP5 (adenocarcinoma ... extracts (12.3 μg) were loaded on a Nupage Bis Tris MiniGel (Invitrogen, Carlsbad, New-Mexico) and migration was performed in non-reducing conditions Monoclonal antibody against CD63 (TS63) was...

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Investigation on anti prion, neuroprotective and anti cholinesterase activities of acridine derivatives

Ngày tải lên : 11/09/2015, 10:05

... Chapter 3: Antiprion activity of acridine analogues 62 3.1 Introduction 62 3.2 Experimental methods 64 3.2.1 Evaluation of antiprion activity 64 3.2.2 Determination of total and cell surface prion proteins ... Steck et al.3 on anti- rickettsial acridines and Elslager et al.4 on anti- bacterial acridine N-oxides were the last major investigations on the antimicrobial properties of acridines.5 Ironically, ... deploying “one-molecule, one-target”-type of therapeutics.77 1.3.3 Prion diseases and other protein misfolding conditions Prion diseases share similar underlying pathogenic conditions with other...

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Expression of EBV genes in nasopharyngeal carcinoma

Ngày tải lên : 05/10/2015, 22:32

... considered to cause the switch from latent infection to - 11 - Introduction lytic infection However IE gene expression cannot be considered synonymous to full viral lytic replication (Rickinson ... posttranscriptional regulator of viral gene expression and essential for virion production (Gruffat et al., 2002) SM protein can activate intronless genes expression and inhibit expression of intron-containing ... BL Only 30-40% cases of this type lymphoma are associated EBV, and only rare cases show LMP1 expression (Knowles, 1999) - 25 - Introduction 1.2 NASOPHARYNGEAL CARCINOMA (NPC) Nasopharyngeal carcinoma...

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