... Ganglia andMovementDisorders I Rationale for Surgical Therapy Basal Ganglia andMovementDisorders Physiology of the Basal Ganglia and Pathophysiology of MovementDisorders Thomas Wichmann and ... Surgical Treatment of Parkinson’s DiseaseandOtherMovement Disorders, edited by Daniel Tarsy, Jerrold L Vitek, and Andres M Lozano, 2003 Myasthenia Gravis and Related Disorders, edited by Henry J ... treatment of Parkinson's diseaseandothermovementdisorders / edited by Daniel Tarsy, Jerrold L Vitek and Andres M Lozano p ; cm Includes bibliographical references and index ISBN 0-89603-921-8...
... Psychological Disorders Alzheimer’s DiseaseandOther Dementias Psychological Disorders Addiction Alzheimer’s DiseaseandOther Dementias Anxiety Disorders Child Abuse and Stress Disorders Depression and ... Huntington’s disease, alcohol-induced dementia, and head trauma Dementia can also be caused by infections to the brain andhereditary diseases like Wilson s disease Huntington’s disease is an ... thrive In Wilson s disease, the body cannot get rid of excess copper, which then accumulates in the brain and various other organs, causing dementia and involuntary movements Wilson s disease is...
... Alzheimer’s DiseaseandOther Dementias Edited by Andrew E Budson and Neil W Kowall The Handbook of the Neuropsychology of Language (2 Volumes) Edited by Miriam Faust The Handbook of Alzheimer’s Disease ... Reilly, Joshua Troche, and Murray Grossman 13 Executive Functioning Robert A Stern, Stacy L Andersen, and Brandon E Gavett 369 14 Emotion and Behavior in Alzheimer’s DiseaseandOther Dementias Christopher ... angiitis, lupus andother vasculidites, sarcoid Renal and hepatic failure, hyper/hypo-thyroidism/calcemia/ natremia, Wilson s disease, metachromatic/ adrenoleukodystrophy GM2 andother gangliosidoses...
... emotion, and behavior A systematic testing of these mental functions is necessary for the effective clinical assessment of the association cortex and its diseases Figure 27-1 Lateral (top) and medial ... cognition; an occipitotemporal network for face and object recognition; a limbic network for retentive memory; and a prefrontal network for attention and behavior ... "storing memories." Cognitive and behavioral functions (domains) are coordinated by intersecting large-scale neural networks that contain interconnected cortical and subcortical components The...
... right handers and 60% of left handers, aphasia occurs only after lesions of the left hemisphere In some individuals no hemispheric dominance for language can be discerned, and in some others ... meaning-appropriate syntax (grammar) Wernicke's and Broca's areas are interconnected with each otherand with additional perisylvian, temporal, prefrontal, and posterior parietal regions, making up ... relative paucity of substantive nouns and action verbs versus function words (prepositions, conjunctions); and if word order, tenses, suffixes, prefixes, plurals, and possessives are appropriate Comprehension...
... reading Wernicke's Aphasia Comprehension is impaired for spoken and written language Language output is fluent but is highly paraphasic and circumlocutious The tendency for paraphasic errors may be ... his dentures: "We don't need it anymore, she says And with it when that was downstairs was my teeth-tick a den dentith my dentist And they happened to be in that bag see? How could ... Table 27-1 Clinical Features of Aphasias and Related Conditions Comprehe nsion Repeti tion Nami of ng Fluen cy Spoken Language Wernicke's...
... is common, and mild right nasolabial flattening may be found, but otherwise the examination is often unrevealing The paraphasic, neologistic speech in an agitated patient with an otherwise unremarkable ... psychiatric disorder such as schizophrenia or mania, but the other components characteristic of acquired aphasia and the absence of prior psychiatric disease usually settle the issue Some patients with ... conjunctions and pronouns The last two features indicate that Broca's aphasia is not just an "expressive" or "motor" disorder and that it may also involve a comprehension deficit for function words and...
... isolated from other regions of the brain Broca's and Wernicke's areas tend to be spared, but there is damage to the surrounding frontal, parietal, and temporal cortex Lesions are patchy and can be ... understanding written language and can express themselves well in spoken or written language They have no difficulty interpreting and reacting to environmental sounds since primary auditory cortex and ... comprehension, and repetition are intact, but confrontation naming, word finding, and spelling are impaired Speech is enriched in function words but impoverished in substantive nouns and verbs denoting...
... in movements of the face and mouth Limb apraxia encompasses apraxic deficits in movements of the arms and legs Ideomotor apraxia is almost always caused by lesions in the left hemisphere and ... the command is ascertained by demonstrating multiple movements and establishing that the correct one can be recognized Some patients with this type of apraxia can imitate the appropriate movement ... (when it is demonstrated by the examiner) and show no impairment when handed the real object, indicating that the sensorimotor mechanisms necessary for the movement are intact Some forms of ideomotor...
... melodic stress and intonation influence the meaning and impact of spoken language For example, the two statements "He is clever." and "He is clever?" contain an identical word choice and syntax but ... two contexts: CVAs and degenerative diseases Aphasias caused by CVAs start suddenly and display maximal deficits at the onset The underlying lesion is relatively circumscribed and associated with ... forgetfulness for recent events and experiences is the cardinal feature of Alzheimer's disease In time, the neuronal pathology in Alzheimer's disease spreads to the language network and a progressive aphasia,...
... car and drive my car into chicago You will back get your car and my car park in my driveway Love, Mom." Comprehension deficits, if present, start with an occasional inability to understand ... GornoTempini and colleagues, three variants of PPA can be recognized: an agrammatical variant characterized by poor fluency and impaired syntax, a semantic variant characterized by preserved fluency and ... on chromosome 17 Apolipoprotein E and prion protein genotyping has shown differences between patients with typical clinical patterns of Alzheimer's diseaseand those with a diagnosis of PPA The...
... lesser impact on overall awareness; there is a paucity of exploratory and orienting acts directed toward the neglected hemispace; and the patient behaves as if the neglected hemispace was motivationally ... more common, severe, and lasting after damage to the right hemisphere than after damage to the left hemisphere Severe neglect for the right hemispace is rare, even in left handers with left hemisphere ... placed on the left side of the tray; and may fail to read the left half of sentences When the examiner draws a large circle [12–15 cm (5–6 in.) in diameter] and asks the patient to place the numbers...
... (oculomotor apraxia) and in accurate manual reaching toward visual targets (optic ataxia) The third and most dramatic component of Bálint's syndrome is known as simultanagnosia and reflects an inability ... the visual identification of objects and scenes For example, a patient who is shown a table lamp and asked to name the object may look at its circular base and call it an ash tray Some patients ... brief saccadic displacements Movementand distracting stimuli greatly exacerbate the difficulties of visual perception Simultanagnosia can sometimes occur without the other two components of Bálint's...
... hemisphere and object agnosia with lesions in the left The Limbic Network for Memory: Amnesias Limbic and paralimbic areas (such as the hippocampus, amygdala, and entorhinal cortex), the anterior and ... The deficit in prosopagnosia is therefore modality-specific and reflects the existence of a lesion that prevents the activation of otherwise intact multimodal templates by relevant visual input ... entorhinal cortex), the anterior and medial nuclei of the thalamus, the medial and basal parts of the striatum, and the hypothalamus collectively constitute a distributed network known as the...
... encephalopathy, paraneoplastic limbic encephalitis, and degenerative dementias such as Alzheimer's or Pick's disease The one common denominator of all these diseases is that they lead to the bilateral ... the greatest phylogenetic expansion in primates and especially in humans The dorsolateral prefrontal, medial prefrontal, and orbitofrontal areas, and the subcortical structures with which they ... hypothalamus, and the limbic thalamus Occasionally, unilateral left-sided lesions can give rise to an amnestic state, but the memory disorder tends to be transient Depending on the nature and distribution...
... initiative, creativity, and curiosity and displays a pervasive emotional blandness and apathy In the frontal disinhibition syndrome, the patient becomes socially disinhibited and shows severe impairments ... of the prefrontal network and the ascending reticular activating system Retentive memory, on the other hand, depends on the stable (offline) storage of information and is associated with the ... the scanning and retrieval of stored information, the inhibition of immediate but inappropriate responses, and mental flexibility The capacity for focusing on a trend of thought and the ability...
... Alzheimer's disease, for example, causes the greatest destruction in medial temporal areas belonging to the memory network and is clinically characterized by a correspondingly severe amnesia There are other ... frontal lobe and leads to a gradual dissolution of behavior and complex attention Primary progressive aphasia is characterized by a gradual atrophy of the left perisylvian language network and leads ... diagnosis and treatment of these patients requires an understanding of the principles that link neural networks to higher cerebral functions FURTHER READINGS Catani M, Ffychte H: The rises and falls...
... Anemia Evaluation / Anemia and Age / 28 Anemia and Ethnicity / 38 Anemia and Pregnancy / 45 Cancer and Anemia / 58 Malaria and the Red Cell / 81 SECTION II: NUTRITION AND ANEMIA Iron Deficiency ... ANEMIAS ANDOTHER RED CELL DISORDERS NOTICE Medicine is an ever-changing science As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy ... people, and is addressed in the chapter on age and anemia Additional sections of the book explore other common concerns in anemia that sometimes fall into a nosologic no man’s land Ease and utility...