why glucose is the principal source of energy for living beings andthe explanation of human diseases
Báo cáo y học: "A hidden reservoir of integrative elements is the major source of recently acquired foreign genes and ORFans in archaeal and bacterial genomes" pdf
Ngày tải lên :
14/08/2014, 21:20
... unlike the e-value, which changes depending on the size of the database We therefore defined the homology cut-off between two sequences when the bit-score of the BLAST hit was above 30% of the bit-score ... different distribution cut-offs (0.l% to 5%) Then, we identified the core genes dataset and the cut-off for which the average detection of simulated HGT (true positives) was the highest but the average ... advantage of the availability of a large number of genomes from closely related organisms The general strategy is the following (Figure 1): for different groups of closely related genomes, a dataset of...
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Báo cáo khoa học: Activation of the plasma membrane H+-ATPase of Saccharomyces cerevisiae by glucose is mediated by dissociation of the H+-ATPase–acetylated tubulin complex docx
Ngày tải lên :
23/03/2014, 11:20
... activity (Fig 1B) These rapid effects of d -glucose suggest action at the membrane level, possibly during the transport of glucose into the cell We therefore studied the effect of 2-deoxy-d -glucose, a ... used at 10 mm The blocking of the ATPase activating effect of glucose was not the result of a toxic effect of 2-deoxy-d -glucose, as subsequent incubation in the presence of 10 mm glucose resulted ... that 88 ± 12% of the complex was dissociated by glucose treatment These results represent the mean ± SD values from three independent experiments Further evidence for the occurrence of the H+-ATPase–acetylated...
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What Is the Cognitive Neuroscience of Art… and Why Should We Care? ppt
Ngày tải lên :
23/03/2014, 13:20
... be; scientists… provide a test of whether this criterion is fulfilled.”2 Or consider the case of neuroaesthetics This new branch of empirical aesthetics is often defined as the study of the neural ... neuroaesthetics (or aesthetic science in general), then perhaps there is cause for skepticism about the utility of empirical aesthetics to researchers in the humanities But is this all it has to offer? ... 1-16 The Journal of Aesthetics and Art Criticism Editor Search The American Society for Aesthetics is soliciting applications and nominations for the position of editor of The Journal of Aesthetics...
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Tài liệu Research " The Dissertation Committee for Fang Yin Certifies that this is the approved version of the following dissertation: Business Value of Information Technology in the Internet Economy " doc
Ngày tải lên :
18/02/2014, 11:20
... where q is the output, xi is the level of input I, α i is the output elasticity of input I, A is a constant, and where N is the number of inputs The Cobb-Douglas production function is the most ... available for most of the companies in the dataset, this study first uses the number of employees as a proxy for the labor input The total labor cost can be thought of as a product of the number of ... provided by other companies The cost of sales of most physical dot coms consists of the cost of merchandise sold and inbound/outbound shipping There are other important distinctions between these two...
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Tài liệu Báo cáo khoa học: Rotary F1-ATPase Is the C-terminus of subunit c fixed or mobile? docx
Ngày tải lên :
19/02/2014, 16:20
... during the forced molecular dynamics calculated with the torque of 56 pNÆnm The secondary structure of c is shown for the time of ns (the end of initial equilibration), 17 ns (half of turnover), ... by a cut-off distance of 1.2 nm The system was equilibrated during ns, and then the rotation of c was forced by a constant torque applied to the coiled-coil portion of c at the level of cK18–cK21 ... this context, as these enzymes lacked the capability to form fluorescent ac cross-links, due to the absence of the point mutation cA285C Figure 3, lane 6, shows the result of the SDS/PAGE of the...
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Báo cáo khoa học: "What is the Minimal Set of Fragments that Achieves Maximal Parse Accuracy?" potx
Ngày tải lên :
23/03/2014, 19:20
... seen, there may be several distinct derivations that generate the same parse tree The probability of a parse tree T is thus the sum of the probabilities of its distinct derivations Let tid be the ... item in the chart equal to the product of the inside probability of the item and its prior probability Any item with a score less than 10 −5 times of that of the best item is pruned from the chart ... corpussubtree t is converted into a context-free rule r where the lefthand side of r corresponds to the root label of t and the righthand side of r corresponds to the frontier labels of t Indices link the...
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Báo cáo khoa học: The phosphorylation pattern of human as1-casein is markedly different from the ruminant species potx
Ngày tải lên :
23/03/2014, 21:20
... species The sequence containing Ser18 in the human as1-casein is part of exon in the human as1-casein gene, which is not present in the ruminant species [13] Ser26, situated in exon of the human ... endoplasmic reticulum and that the formation of this complex is required for their efficient export to the Golgi apparatus [21] Whether a similar scenario exists in the human system remains to be ... not likely that the lack of identification of a highly phosphorylated peptide in as1-casein is due to limitations of the techniques used Finally, MALDI-TOF MS analysis of native human as1-casein...
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why we talk the evolutionary origins of language mar 2007
Ngày tải lên :
11/06/2014, 09:45
... of the source of food she is indicating) The reference to the source of food consists of several complementary codes, notably one for the direction to take and one for the distance to cover These ... evolved out of simulations of Xight, performed outside the hive When the dance is done in the darkness of the hive, the replacement of the angle of the sun by the bee’s alignment, vertical rather than ... that the immediate eVect of the communication act is the making of a mental representation If that is the case, then the eVect of one of these monkeys giving the call usually associated with the...
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the engine is the beating heart of the airplane 88 pptx
Ngày tải lên :
27/06/2014, 23:20
... ignites the fuel-air mixture Cylinders: The controlled burn of the fuel-air mixture occurs in the cylinders Pistons: The controlled burn forces the piston to move within the cylinder Rings: Piston ... encircle the piston and seal the combustion chamber Crankshaft: Attaches to the connecting rods and the propeller The motion of the pistons turns the crankshaft Connecting Rods: Attach the pistons ... wear out They rust because the oil drains off the cylinder walls and the moisture in the air then reacts with the iron in the engine The rust creates roughness, which increases wear Piston aircraft...
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10 Reasons Why Now is the perfect Time to get serious with Mobile Web
Ngày tải lên :
11/07/2014, 21:51
... the year of the mobile web 2007: the year of the mobile web 2008: the year of the mobile web 2009: the year of the mobile web 2010: the year of the mobile web lim 2005: the year of the mobile ... 2006: the year of the mobile web small ma 2007: the year of the mobile webrket bad browsers 2008: the year of the mobile web costly data 2009: the year of the mobile web ns pla 2010: the year of the ... will be local ads! – Mobile display advertising is not dead – THE FUTURE OF MOBILE ADVERTISING IS IN PULL, NOT PUSH HOW OFTEN DO YOU LOOK AT MOBILE ADVERTISING? The Nielsen Company, September...
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This is the first version of this article to be made available publicly. docx
Ngày tải lên :
09/08/2014, 20:20
... characteristic of the distribution, cf Fourier or Laplace transforms, e.g Feller (1971) [8] In fact the mgf is a Laplace transform Knowing the transform means knowing the distribution It is defined ... using the fact that p-values for the unchanged genes follow a uniform distribution The present approach is based on the moment generating function (mgf), which is a transform of a random distribution, ... and p(α) is the proportion of genes judged significant Furthermore, the criterion C = FP + FN is minimised by choosing an optimal pair of values of the tuning parameter S0 in the SAM statistic Tusher...
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báo cáo khoa học: " Is the basal area of maize internodes involved in borer resistance?" docx
Ngày tải lên :
11/08/2014, 11:21
... to the area at the base of the internode where the rind tissue is light green or white in contrast to the darker green color of the rest of the internode [23] For accuracy, we have renamed this ... attack in the basal internode area For these analyses, we evaluated the composition of rind, which is the initial entry point for larvae, and the pith, which is the tissue upon which the larvae ... EPS20_Short_LIBRC3 Page of 12 could result in higher resistance by decreasing the size of the larval entry area Nevertheless, the role of this mechanism in other genetic backgrounds, such as in the synthetic...
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Báo cáo y học: "Dynamic models of immune responses: what is the ideal level of detail" pptx
Ngày tải lên :
13/08/2014, 16:20
... pathogenesis and pathogen time-courses The number of components [7,36] that can be modeled is smaller than in discrete models because of the increase in the number of parameters The state of the variables ... compatible with the existing experimental knowledge on the pathogenesis The distribution of the parameter values for each immune component in the model tells us about its role in the pathogenesis Recent ... effectively to study the progression of the infections Acknowledgements This opinion is an outcome of the discussions at the workshop organized in June 2008 at the Center for Infectious Disease Dynamics...
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Báo cáo y học: "bEstrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly" docx
Ngày tải lên :
14/08/2014, 08:21
... have had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis Additional data files The following additional data ... for ageassociated genes Using a binomial distribution we calculate that, based on the size of the human GenAge database (243 genes), the total number of genes on the U133 array (13,290) and the ... were excised and bisected at day after wounding, with one-half of the sample processed for histology Histological sections were prepared from biopsy/mouse wound tissue fixed in 10% buffered formalin...
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Claudin 1 is the direct target of RUNX3 in gastric epithelial cells
Ngày tải lên :
11/09/2015, 09:00
... CLAUDIN-1 IS THE DIRECT TARGET OF RUNX3 IN GASTRIC EPITHELIAL CELLS CHANG TI LING (M.Sc., National University of Malaysia) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MEDICINE ... 1999, the Nomenclature Committee of the Human Genome Organization (HUGO) adopted the use of the term ‘RUNX’ to refer to the genes encoding the runt-related proteins, also an abbreviation for the ... protein’ The mammalian RUNX proteins and their synonyms as well as their locus are as listed in Table 2.1 The order of the numbers was given according to the order in which the knock-outs for each of...
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Báo cáo y học: "Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary"
Ngày tải lên :
02/11/2012, 11:12
... single pathological entity and therefore there is no single strategy for their prevention Conflict of interest The author has declared that no conflict of interest exists References Czeizel AE, ... pregnancy after the prenatal diagnosis of severe fetal defects was also named as secondary prevention Recently the WHO and other international bodies have excluded this approach from the term “prevention” ... Hungary about 20% of major congenital abnormalities (8.7% in the total group) were terminated after the prenatal diagnosis of defects Tertiary prevention: complete recovery of congenital abnormalities...
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Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly doc
Ngày tải lên :
18/02/2014, 06:20
... involved either in the assembly of the immature HIV-1 capsid, or in the reassembly of CA into a mature capsid The detailed description of the structure and conformational dynamics of these interfaces, ... and they appear to be unusually flexible themselves Accordingly, there is substantial evidence for the occurrence of different conformational rearrangements of CA during the assembly of both the ... involved The structural description of the dimerization interface in the isolated CTD dimer is fully consistent with descriptions of the CTD–CTD interface in the mature HIV-1 capsid These latter...
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Tài liệu Báo cáo khoa học: The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly ppt
Ngày tải lên :
18/02/2014, 06:20
... dimerization of the whole CA in solution [22] The peptide with the highest affinity for the whole CA has the sequence IPVGEIYKRW, which corresponds to the a-helix of NTD This region is important for the formation ... formation of CA hexamers [6]; therefore, this peptide could inhibit the formation of the hexamers, and assembly of the HIV-1 capsid, but no evidence is yet available A peptide-mimicking the dimerization-helix ... chromatography and isothermal titration calorimetry The three techniques yielded similar values for the apparent dissociation constant of the complex, in the order of 50 lm, which is only three-...
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Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
Ngày tải lên :
18/02/2014, 06:20
... (PA) [2,3] Therefore, by competing with the non-enzymatic synthesis of QA, ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway, and is a medically ... of the model has been assessed using the program procheck [23] Ninety per cent of the residues fall in the most favoured regions of the Ramachandran plot, with Asn148 and His269 falling in disallowed ... dimeric forms in solution [18] Therefore, the available structural data suggest Fig Ribbon representation of the overall structure of hACMSD The (a ⁄ b)8 barrel domain is colored in light blue and the...
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Tài liệu Báo cáo khoa học: Evidence for noncooperative metal binding to the a domain of human metallothionein ppt
Ngày tải lên :
19/02/2014, 00:20
... nature of the metal-binding reaction within each of the domains Thus, the goal is to elucidate the metallation mechanisms of the individual domains, in the hope, initially, of simplifying the interpretation ... Investigation into the metal-binding mechanism of the isolated a domain was carried out on the recombinantly synthesized a domain fragment of human MT isoform 1a (a-rhMT-1a) The recombinant protein ... binding of the second metal ion, and so forth Experimentally, this translates into the detection of only the initial species, in this case the metal-free protein, and the final species, which is the...
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