... polymorphism was associated with an increased risk of coronary heart disease [9,22] whereas others failed to demonstrate this association [23-25]. Furthermore, a recent meta-analysis study ... statistically. Statistical analysis of the data analysis was carried out using the ANOVA test. Prevalence of alleles and genotype among cases and control subjects were counted and compared with ... Coagul Fibrinolysis. 2002;13(3):271-5. 53. Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG. MTHFR 677C >T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA. 2002;288(16):2023-31....
... 40%).Therefore, it is not clear if a catalytic triad or a catalytic diadconsisting of only Ser and His is required for catalysis.In this study, we describe a mutational analysis andmechanistic investigations ... to directinvolvement of this residue in substrate binding.DiscussionFor a long time, the biochemical role of TEIIs, which areencoded by distinct genes associatedwith microbial NRPSand PKS ... thought to be involved in catalysis in the caseof the mammalian TEII associatedwith primary metabo-lism, is not conserved among the microbial TEIIs ofsecondary metabolism (Fig. 1). Mutants of these...
... chronic gastritis and ulcer(normal group), 50 with IM including adenoma (highrisk group), 40 with EGC (EGC group), 45 with AGC with- out distant metastasis (AGC group), and 42 with meta-static ... gastriccarcinogenesis. Serum HMGB1 levels were significantly associatedwith depth of invasion, lymphnode metastasis, tumor size, and poor prognosis (p < 0.05). However, HMGB1 levels were not associated with ... accord-ing to histologic type (intestinal vs. diffuse) and this is similar to the results by Kuniyasu et al. [15]. These resultsmay mean that HMGB1 was not affected by tissue histo-logic type, and...
... Multivariate analysis of factors associatedwith ICU LOS Table 2 demonstrates that hypoglycemia—minimum BG < 50 mg/dL as well as minimum BG 50–69 mg/dL is independently associatedwith prolonged ... 48 hours of ICU admission; in the NL cohort, 72% of the patients with hypoglycemia in the NL cohort had an episode within the first 48 hours of ICU admission. Figure 5 displays the strong association ... associatedwith mortality on univariate analysis and therefore was not entered into the multivariate model. Mortality is defined throughout as hospital, not ICU, mortality. Statistical analysis was...
... variable inlogistic regression models, one unit of increased BMI(1 kg/m2) was associatedwith a 3.1% increase in AHR risk(CI 1.01–1.05; p , .005) in all subjects. For men, this riskwas 3.4% ... a 25 kg weight gain was associated with a 2.5-fold increase in the risk for diagnosisof asthma compared with no significant weight gain.11In across-sectional analysis of 18,000 children aged ... the two. Our study estab-lished obesity as a risk factor for new diagnosis of asthma,the risk increasing with higher levels of obesity. Thesefindings should be the basis for future controlledinvestigations...
... medialis at the patellofemoral joint is alsosupported by electromyography studies, which demonstratedthat delayed activation of vastus medialis relative to vastus lat-eralis isassociatedwith ... results in a pain-free population without clinical knee oste-oarthritis suggest that increased cross-sectional area of vas-tus medialis, whichisassociatedwith participation in vigorousphysical ... study is unknown. Thus, the aim ofthis study was to examine the determinants of vastus medialisand lateralis cross-sectional areas and whether vastus media-lis cross-sectional area is associated...
... Research Divisions. We also thank Dr Olle Olerup for providing us with HLA typing kits, Miss Diab Diab for technical assistance with HLA typ-ing, and Mr Ben de Jong for technical assistance with serum ... Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's ... study and is respon-sible for the Blood Bank in Umeå.HS assisted in the statistical analyses and discussions.AcknowledgementsWe gratefully acknowledge the technical assistance of Mrs Lisbeth...
... mechanism through which bcl-2inhibits apoptosis is not fully understood [19]. In thepresence of bcl-2 overexpression, the ability of the cell toremove genetic and cell damage through apoptosis is ... metastases and one for disease in the axilla, all with palliative intent.ImmunohistochemistrySections of paraffin-embedded metastasis specimens wereinitially stained with hematoxylin-eosin ... expression were statisticallysignificant. Similar results were obtained using univariateanalysis (P > 0.05) and Cox's multivariate analysis.Table 1: Distribution of 50 patients with cutaneous...
... -168A>G polymorphism has convinc-ingly been associatedwith MHC2TA gene expression, it is unclear whether the polymorphism itself is functional orwhether it is in linkage disequilibrium with one or ... Revisions requested: 6 Apr 2006 Revisions received: 8 May 2006 Accepted: 17 May 2006 Published: 15 Jun 2006Arthritis Research & Therapy 2006, 8:R97 (doi:10.1186/ar1974)This article is online ... increased risk for RAin a recessive model (GG + GA genotypes versus AA geno- type; OR = 0.93, 95% CI = 0.69–1.25) or a co-dominantmodel (GG versus genotype GA versus genotype AA geno- type; OR...
... Comparison of risk factors for vascular disease inthe carotid artery and aorta in women with systemic lupuserythematosus. Arthritis Rheum 2004, 50:151-159.35. Vitali C, Bencivelli W, Isenberg ... used to distinguish betweenfunctional and nonfunctional protein [28]. Unfortunately, noDNA is available from our patient cohort and for this reason wecannot correlate MBL genotype and risk of ... analysis.As a consequence of the low number of opportunistic infec-tions since lupus onset in our patients, a further analysis of var-iables associatedwith the occurrence of opportunisticinfections...
... analysis was performed using GraphPad PrismVersion 4 (GraphPad Software, San Diego, CA, USA).ResultsIFIH1 A946T is not associatedwith RA susceptibility or severityAllele and genotype frequencies ... Revisions requested: 27 Feb 2007 Revisions received: 16 Apr 2007 Accepted: 18 Apr 2007 Published: 18 Apr 2007Arthritis Research & Therapy 2007, 9:R40 (doi:10.1186/ar2179)This article is ... the interferon induced with helicasedomain 1 (IFIH1) A946T (rs1990760 A>G) variant inrheumatoid arthritis (RA), as this was recently associated with susceptibility to type 1 diabetes. A total...
... definitions for LLI.The most probable explanation for this finding is that, despiteopinion found in textbooks, no association actually exists. Thisreasoning is consistent with the near absence ... 11cases with ipsilateral longer leg, and 17 cases with bilateralGTPS) and in 163 subjects without GTPS; therefore, 13.7%of subjects with GTPS had a LLI compared with 14.1% ofthose without ... 2007 Revisions received: 12 Apr 2008 Accepted: 29 May 2008 Published: 29 May 2008Arthritis Research & Therapy 2008, 10:R62 (doi:10.1186/ar2433)This article is online at: http://arthritis-research.com/content/10/3/R62â...
... medialis at the patellofemoral joint is alsosupported by electromyography studies, which demonstratedthat delayed activation of vastus medialis relative to vastus lat-eralis isassociatedwith ... inmultivariate analysis. BMI was positively associatedwith vas-tus medialis cross-sectional area in multivariate analysis, with a similar trend observed with vastus lateralis. Participation invigorous ... results in a pain-free population without clinical knee oste-oarthritis suggest that increased cross-sectional area of vas-tus medialis, whichisassociatedwith participation in vigorousphysical...
... competing interests.AcknowledgementsThis work is supported by an Arthritis Research Campaign Clinical Fel-lowship grant (grant number 18848 to TET) and an Arthritis ResearchCampaign infrastructure ... Foundation Trust, Department ofRheumatology). HJ is supported by an Arthritis Research CampaignEducational Research Fellowship Grant (grant number 17883). VFP is supported by a PhD scholarship from the ... associates with a reduced prevalence of the meta-bolic syndrome in rheumatoid arthritis patients over the ageof 60: more than just an anti-inflammatory effect? A cross-sectional study. Arthritis Res...