... obvious, the appropriate management of incidental findings in research studies has not been raised in musculoskeletal imaging It is important given the increasing use ofMRIinthe investigation of ... of such lesions; a much larger study would be required to give a more precise prevalence estimate However, this isthe first study in this area Our findings raise issues for the planning of studies ... an MRI radiologist or other suitably trained specialist review all the images or just the baseline images in a longitudinal study This will also add to the cost ofthe research study Despite the...
... participants themselves, such as what actions senior leaders did to assure the team was successful andwhat role physicians and nurse champions played in winning the support of their colleagues [18] ... quality and safety teams addressed in this scoping review Across the studies, authors seldom provided essential elements of SQUIRE reporting More specifically, efforts to address a number of issues ... missing data (n = 10) Only one-half ofthe authors contextualized findings within existing literature The weakest section of reporting across studies was planning ofthe interventions, with less...
... possibly because the SF-36 assesses a wide range of characteristics that are not directly related to visual acuity This distinction between the two instruments is consistent with previous research ... when assessing functional impairment associated with visual acuity, and separate assessment of binocular acuity is not required [32] Statistical analyses The health outcomes measures used inthe ... performed withthe subset ofpatients who had at least one VFQ-25 subscale present at both baseline and month 18 (this subset is called the "change analysis sample") Analyses were conducted to assess...
... assessments Thepatients were assessed as inpatients Demographic data were collected at admission Thepatients were asked to estimate their fall incidence during the past six months, and if they ... destabilizing visual tilts [9,15-17] In some cases, assessment of quiet stance on a firm surface lacks thesensitivity to distinguish healthy subjects from patientswith balance disorders [18] A method ... was irrespective of visual input and sway direction (Table 4) Discussion The main finding of this study is that STN stimulation alone improves clinical performance tests that mimic activities of...
... possibly because the SF-36 assesses a wide range of characteristics that are not directly related to visual acuity This distinction between the two instruments is consistent with previous research ... when assessing functional impairment associated with visual acuity, and separate assessment of binocular acuity is not required [32] Statistical analyses The health outcomes measures used inthe ... performed withthe subset ofpatients who had at least one VFQ-25 subscale present at both baseline and month 18 (this subset is called the "change analysis sample") Analyses were conducted to assess...
... populations to test its psychometrical properties Secondly, it is necessary to analyse thesensitivityofthe TOOL in detecting changes in longitudinal studies Conclusions The Spanish validation ofthe ... comparisons considering the skewed distribution of data Reliability The internal consistency ofthe questionnaire was analysed using Cronbach s a Test-retest reliability ofthe scores was also examined ... tested in further investigations with schizophrenic and bipolar patients showing a worse health status in order to test discriminative power The characteristics ofthe sample may limit the scope of...
... border ofthe pelvis as intheCT scan, using multiple-bed position Attenuation was corrected by using theCT images The processed images were displayed in coronal, transverse, and saggital planes ... pelvis was acquired with 5-mm slice thickness, using a standardized protocol with 140 kV and 80 MA with contrast injection The subsequent PET scan was acquired from the base ofthe skull to the inferior ... improvements in diagnosis, accurate staging, RTP, and assessment of tumor response to the prescribed treatment in a variety of tumor sites including the MPM [10-16] PET imagingis based on biochemical...
... illnesses, the use of glucocorticoids or other causes of immunosuppression, fluid intake/output and balance, vital signs, and chest radiographic findings The clinical disorder associated with ... because the sickest patients who present with severe shock, catastrophic injury, or refractory hypoxemia die during the first days of ALI and thus were not included in this analysis Previous studies ... per standard deviation increase or decrease in each variable to allow for equal comparisons between different variables The goodness -of- fit ofthe logistic-regression model was assessed with the...
... ascertainment ofthe exposure/outcome for the cases and controls exposed and comparison cohorts Conclusions Given these numerous problems with both study designs in assessing the infection risk with ... Nonetheless, most analyses of observational studies reported an increased risk of infection, which conflicts withthe result ofthe RCTs The dose of GC therapy varied both within and between RCTs ... effects in both directions are a consequence of low numbers of events, despite a meta-analysis of all existing studies Inconsistent capture or reporting of infections has an impact on the weighting...
... by other investigators as 'early' Nonetheless, the findings of our study provide the basis for re-examining whether the timing of tracheostomy may impact clinical outcomes Inpatientswith resolving ... our observations, it is important to address the limitations of this study First, this was a retrospective analysis of a dataset that, while prospectively collected, was used to address a separate ... spontaneous respiratory rate of 20–28/min and involved a step-wise reduction inthe level of pressure support The protocol permitted overnight resting at the discretion ofthe attending intensivist In addition...
... [parents’ assessment], p = 0.032 [patients assessment]), global QoL (p = 0.012 [parents’ assessment]) and interests and hobbies (p = 0.023 [patients assessment]) Withthe exception of ‘interests and ... dose of OROS® MPH and had safety data reported Other assessments Results Problems concerning social interactions and tasks were assessed via several non-validated questions At each ofthe study ... twothirds of individuals with persistence of symptoms associated with continued clinical and psychosocial impairments [5] A detailed longitudinal study of remission in boys with ADHD showed that syndromatic...
... infarction by strain, sSR, dSR or S after AMI The main finding of this study isthe significant difference of strain, SRe and tissue velocities between infarcted and non-infarcted segments demonstrated ... patientswith vessel disease a stenosis > 50% was found inthe circumflex artery inpatientsandinthe right coronary artery inpatients Complete revascularization inthepatientswith 2-vessel disease ... according to 2DS, dSR and tissue velocities, which is depicted in Table and Figures 2, Infarcted segments demonstrated significantly decreased 2DS as well as tissue velocities in comparison to...
... visible in either ofthe two chains, and 11 (chain A) or 13 (chain B) C-terminal residues including the hexahistidinyl tags also appear unstructured The binding site region of chain B contains ... PDZ domain structures Figure shows a superposition of SAP97PDZ2 C37 8S structure withthe NMR structure of PSD-95PDZ2 andthe crystal structure of SAP102 The backbone structures are highly similar, ... contacts at the bottom ofthe ligand-binding pocket, there is a correlation between binding of ligand, changes in cell dimensions, andthe opening and closing ofthe pocket; whenever the ligand is...
... to severe plaque psoriasis (Table 1) Assessing the burden of psoriasis on health-related quality of life SF-36 summary scores Based on the 2002 MEPS data, baseline PCS scores for patientsinthe ... populations [9] The SF-36 was included in both the REVEAL and NSFHS studies The Short Form-12 Health Survey (SF-12) (Version 1), which was used inthe MEPS survey included in this analysis, contains ... understand the impact that psoriasis and its treatments have on a patient 's functioning and well-being, it is important that clinical trials of new psoriasis treatments assess patient HRQOL Successful...
... addition to patients using avoidance strategies as a coping mechanism, other patientswith pain will have the tendency to cope with pain using persistent strategies [8] These patients persist inthe ... Netherlands Instruments For all participating patients: Psychological distress The Dutch Version ofthe Symptom Checklist (SCL-90) was used to assess psychological distress The SCL-90 is a multidimensional ... profiles ofpatientswith fibromyalgia and other pain syndromes (CRPS and CLBP) are presented in Table Since the distribution of scores for the total score of psychological distress including several...
... disease-specific instrument For the analyses, the total score was used instead to assess the SGRQ 's properties Statistical analysis Differences between baseline characteristics were tested using t-tests for ... patientsThe ability of an instrument to discriminate between disease stages was analyzed using linear mixed regression models, adjusting for age, sex, smoking status and time of assessment (admission ... disease severities The main problem ofthe SF-12 in this self-administered setting was the high proportion of missing values For less than 55% of all patients, a comparison of utility values...
... losses such as the death of a person close to us or loss of work role or income These losses, when accompanied with chronic stress, may result in social isolation that is turn worsens depression ... Necessity of hospital admission and degree of disability caused are also possible indices of severity Most of these considerations, however, yield circular reasoning as definition of disability includes ... declines inthe levels of both depressive symptoms and hopelessness [55] The presence of mixed symptoms (pseudo-unipolar depression) or agitation substantially increases the risk of attempted and...
... Effect of Rituximab therapy onlupus erythematosusand clinical parameters inpatientswith systemic lupus erythematosus Twenty-two systemic lupus erythematosus patientswith active disease and ... with systemic lupus erythematosus nuclear cells (PBMNCs) inpatientswith systemic lupus erythematosus Freshly isolated PBMNCs from patientswith systemic lupus erythematosus were fixed, stained ... unexpected induction of apoptosis of T cells upon Rituximab therapy Since only B cells express CD20, it is evident that this induction of apoptosis is not due to the direct action of this chimeric...
... months inpatientswith multiple locations, 13 months with metastases to the skeletal system, 21 months with liver metastases, months with brain metastases and 15 months with skin metastases There ... regarding overall survival (OS), disease-free survival (DFS), locoregional progression-free survival (LPFS), distant metastases-free survival (DMFS) and causes of death Statistical analyses were ... disease (7 months) Distant metastases and distant metastases-free survival Distant metastases-free survival was median 66 months (range, 2-156 months) Forty-five of our patients (35%; 41 male and...