... processing systems.We will focus on an important linguistic aspect of polarity classification: examining theroleof avariety of simple, yet under-investigated, linguis-tic knowledge sources in ... normalization.7FollowingPang et al. (2002), we use frequency as presence. In other words, the ith element ofthe documentvector is 1 if the corresponding unigram is present in the document and 0 otherwise. The ... accu-racy using only unigrams as features. Wethen examine theroleof four types of sim-ple linguistic knowledge sources in a po-larity classification system. 1 IntroductionSentiment analysis involves...
... advantage, the ACM copyright notice and the title ofthe publication andits date appear, and notice is given that copying is by permission ofthe Association of Computing Machinery.To copy otherwise, ... than inthe inheritance case in that no sharing map is involved; an attempt to vm_write one mapping ofthe memory object would merely replace that mapping, rather thanreflecting it in other ... version of Mach isin use onover 200 workstations and large timesharing systems within the CMU Department of Computer Science. It is alsobeing used on dozens of machines outside the Department, including...
... The tumor invades the cervical stroma (arrowhead). c DWI with b = 1,000 s/mm2shows awell-defined hyperintensity mass inthe cervical area. The shape of the uterine cervix is distorted inthe ... of peritoneal dissemination is rendered difficult by the poor contrast resolution vis-a-vissurrounding organs. DWI clearly discriminates the abnor-mal signal intensity of peritoneal dissemination ... controls).Further study using larger numbers of patients is neededto establish the accuracy of ADC measurement in monitoring the effect of therapy for uterine cervical cancer.For the diagnosis, McVeigh et...
... of PKA inthe mitochondrial targeting of CYP2E1 The roleof PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches. The first approach involved measuring the level of mito-chondrial ... suggesting the importance of PKA in protein trafficking [47,48]. In this study, we usedPKA knockout mutants to determine theroleof PKA in mitochondrial targeting of CYP2E1. In mutantslacking ... mitochondria-targeting signal in the yeast system. Mitochondrial localization of intact CYP2E1 in yeast cellsBecause ofthe existing ambiguity inthe literature on the nature and extent of CYP2E1 import into...
... providedfurther insight into the molecular mechanism driving the formation ofthe covalent C115–fosfomycin adduct. Aconservative exchange of K22 to arginine maintains fosfo-mycin binding, while ... form ofthe protein. The results obtained with the K22V/R120K doublemutant protein point toward a central roleof arginine 120 in the conformational process occurring during catalysis.Therefore, ... mechanism for the formation of a covalent adduct. This in turn suggeststhat UDPNAG assists inthe assembly ofthe properinteractions inthe active site by stabilizing the closedconformation of the...
... assisting businesses in their provision of services to governmentCheyney UniversityDisadvantaged Business Enterprise – collaborating with business, industry and government agencies; providing ... UniversityRegional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... UniversitySmall Business Initiative inthe Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new businessIndirect Contributions...
... that the Trp169–His210 pair functions inthe high catalytic activity of thisprotease at pH9 [10]. Further interest inthe aromaticstacking isintheroleofthe electrostatic properties in enzymatic ... the pKa of His210 is 2 pH units higher than that of His57 is the buried charge interaction with Asp113. The shieldingeffect of Asp113-His210 by Trp169 was supported by the independency ofthe ... position. Inthe struc-tural deviation, the solvent ASA ofthe side-chain of His210increased with the decrease in size ofthe side-chain atresidue 169 (Table 1 and Fig. 3A). However, the ASAs of Asp113...
... decrease in the activation energy, which results from an increasedprotein flexibility, either ofthe whole protein or of a specificdomain in some multidomain proteins. Furthermore,evidence from the ... importance ofthe Gly pair, located inthe vicinity of the active site ofthe cold adapted enzyme and to study itspotential roleinthe establishment of its psychrophiliccharacter.This work uses, in ... of the model, the behavior ofthe G261A variant can beinterpreted in terms of constraints introduced by the Alaside chain. The presence ofthe additional Gly at position261 possibly offers increased...
... DptF is GLDSV,indicating that this putative ACP domain is one of the few ACPs in which valine replaces isoleucine (I) orleucine (L) inthe conserved sequence. To determinewhether DptF isthe ... by the C domain ofthe initiation module of dapto-mycin. That DptE and DptF are involved in the lipidation process of daptomycin was first shown byMiao et al. [1]. In their work, the daptomycin ... of the nonribosomally synthesized peptide is necessary.Here, we report the results of a steady-state kineticanalysis of DptE. The aim of this kinetic study was todetermine the specificity of...
... clarify the effect ofthe interface mutations on the antigen-binding affinity. To investigate systematically thisunsought relationship between the antigen-bindingaffinity of Fv and the VH⁄ VLinteraction ... However, as a result of covalentlinkage ofthe variable domains through the C-terminalconstant domains, not much is known about the distri-bution ofthe VH–VLinteraction strength in naturalB-cell ... to retain the specificity and affinity to antigen in itself [7,20]. Atleast for these antibodies, theroleofthe VLdomainmight be to increase the affinity by supporting the VHdomain. The phenomenon...
... Cardie, Vincent Ng, David Pierce,Chris Buckley. Ex-amining theroleof statistical and linguistic knowledgesources in a general-knowledge que stion answering sys-tem. In Proceedings ofthe 6th ... example, inthe case of questionQ209: “Who invented the paper clip ?”, the expected answer type is PERSON and so is the subject ofthe verb invented , lexicalized as the nominalization inventor. ... Reims?Q-711 :What are the names ofthe tourist attractions in Reims?Q-712 :What do most tourists visit in Reims?Q-713 :What attracts tourists to Reims?Q-714 :What are tourist attractions in Reims?Q-715:What...
... graduation. Bussey (1967), in a study inthe U.K., found that the most popular occasion is Christmas, which is followed by birthday. This finding is just reverse ofthe finding of Belk (1973). Ruth, ... choice of gift is one ofthe most important decisions inthe study of consumer in gift-giving behavior. Lows et al. (1971), inthe British study, categorized the most relevant types of gifts ... their brand attitude, may suggest an interesting implication for the new brand advertising strategy. Instead of focusing on the content ofthe message which only emphasizes the benefits of...
... predictors of wilt. Race is significant in some models (with Blacks having an advantage) but not others. Somewhat surprisingly, income is never significant. Also, when youth savings is included inthe ... school. Conley (2001) finds that a doubling of net worth results in an 8.3% increase inthe probability of attending college. Further, when net worth is included inthe model, Black youth are ... Youth savings. Youth were asked in 2002 whether they had a savings or bank account in their name. If they had an account, they were also asked whether they were saving some of this money for...
... that the increase of Glc6P inthe presence of S4048 was caused by the inhibition of Glc6P hydro-lysis inthe absence of detectable changes in glucosephosphorylation.S4048 causes inactivation of ... control of glycolysis and glycogen synthesis by glucokinase overexpres-sion. The validity of S4048 for testing theroleof Glc6P was supported byits lack of effect on glucokinase binding and ... Seoane J, Guinovart JJ &Agius L (2000) Theroleofthe regulatory protein of glucokinase inthe glucose sensory mechanism of the hepatocyte. J Biol Chem 275, 10597–10603.24 Gomis RR, Cid...
... mem-ber of subfamily A of family 94 (there is more about the activity of this enzyme inthe accompanying mini-review by Pinot & Beisson [4]). Over 11 000 P450genes are included in this internationally ... tightbinding affinity was demonstrated towards lauric acid,resulting inthe synthesis of mainly x-1 hydroxylatedlauric acid, suggesting a roleinthe lipid oxidativemetabolism. Interestingly, the ... biologicalfunctions. The proteins displaying the lowest similarity to the other P450s are those involved in oxylipin biosynthesis(2–6% amino acid identity). This can be explained in part by their bifunctional...