... donors
and patients with abdominal surgery but without signs of
infection or inflammation. Secondly, an evaluation of the
association ofthe MIF polymorphisms withthe survival
of severe sepsis patients ... on the fraction of non-surviving patients
and on the genotype relative risks the statistical power of
the significant associations were 81%, 96% and 91%,
respectively. The relative risks of -173 ... associ-
ation ofthe MIF -173 promoter SNP and the MIF -794
CATT
5-8
microsatellite withthe incidence and outcome of
severe sepsis by the comparison with two control groups.
Our data indicate that neither...
... fibrocartilaginous disc explants. Our findings are
consistent withthe hypothesis that relaxin-mediated induc-
tion of MMPs isassociatedwiththe loss of matrix macro-
molecules that could compromise tissue ... to the loss of disc collagen and
GAGs. The lack of effect on GAG synthesis further
validates the importance ofthe degradative component of
the remodeling cycle in relaxin's modulation of ... similar
diseases of other joints, TMJ disorders occur primarily in
women of reproductive age [14]. Given the gender and age
distribution of these disorders and the relaxin-induced loss
of matrix...
... The intracellular concentration of heme
is maintained by the rate of its synthesis and degrada-
tion [1]. Many enzymes and their regulators are
responsible for heme synthesis [1,2]. On the other
hand, ... of HO-1 and HO-2 mRNA. The intensity ofthe signals representing HO-1 or HO-2 mRNA was normalized with respect to
the intensity ofthe 18S rRNA signal. The ratio of each normalized value to the ... induced the expres-
sion of HO-1 mRNA and protein without affecting
the concentration of GAPDH mRNA and b-actin
(Fig. 4A,B). Likewise, the selective reduction of HO-2
mRNA with HO-2 siRNA induced the...
... excluded.
The expression ofthe N-methyl -associated epitope is
suppressed in the phase variant 811. The presence of 10- to
20-fold lower amounts of 2 and 3 in strain 811 could be due
to the presence of ... and
methods. On top ofthe plasmids a schematic diagram ofthe 32-kb gene locus of L. pneumophila wild-type RC1 required for LPS biosynthesis is
depicted (adopted from [17]). The direction ofthe operons ... acid was
the smallest one that displayed t hese signals and, moreover,
the relative intensity of these signals was the highest
compared to other pools from the same strain. Therefore,
further structural...
... protein levels were inversely
associated with lymph node met astasis of gastric carci-
noma. Furthermore, the reduction of CD9 protein was
associated with distant metastasis of g astric cancer. Our
results ... strikingly associatedwiththe tumor
status and the distant metastasis. Furthermore, CD82
protein expression was inversely associatedwith the
pTNM stages. These results were consistent with pre-
vious ... strongly
expressed on the cell su rface in the early stage of malig-
nant melanoma but weakens in the more advanced
stages [25]. There is still no report showing that it is
associatedwith other type of cancer....
... (DMARDs)
or prednisolone at either the time of analysis or in the past.
Introduction
The production of rheumatoid factor (RF) IgM is one of the
hallmarks of RA and is frequently associatedwith more
severe ... found to be associated not only with produc-
tion of RF [22], but also production of a variety of other
autoantibodies [2,6,23,24]. The goal ofthe present study
was therefore the analysis of frequencies ... arthritis (RA) patients. The
percentage of CD19
+
cells from total peripheral lymphocytes is plotted
on the x axis, and the number of patients in each frequency range is
plotted on the y axis. The...
... in the TNF-RII gene,
but not the TNF-RI gene, isassociatedwith circulating levels
of TNF receptors in a population of Caucasian RA patients,
and that this polymorphism is also associatedwith ... released by T cells were associatedwith serum
levels (unpublished observations).
The association ofthe TNF-RII T676G polymorphism with cir-
culating sTNF-RII levels is consistent with a previous study
[36] ... although there is a sug-
gestion from this study that the GG genotype is more frequent
in patients with established disease. There were no significant
differences in the serum levels of either sTNFR...
... interest in the study of
the molecular mechanisms of action of this
polymorphism. Because these results were based on
the low frequency of A/A
, they might be inconsistent
due to the random ... G/G ofthe
PTPN11 gene encoding SHP-2 increased the risk of
gastric atrophy among the seropositive subjects [18].
The present study examined the association of a
polymorphism of Gab1 with ... evidence of H. pylori infection
because ofthe earlier presentation or diagnosis of
cancer.
In summary, the Gab1 A/A was associatedwith
the low risk of H. pylori infection while the G/A and...
... [17]. The extent to which any of the
ultrasound criteria contributed to the subjectivity of the
diagnosis was not assessed and to date, we are unaware of
any other study that has attempted to further ... for the early identification and intervention
of this condition. Early diagnosis and intervention is war-
ranted since there is considerable evidence that women
with PCOS are at increased risk ... Sancho J, San Millan JL:
Receiver operating characteristic analysis ofthe perform-
ance of basal serum hormone profiles for the diagnosis of
polycystic ovary syndrome in epidemiological studies....
... pills support the role of capsaicin in the development of coronary vasospasm
through increased sympathetic stimulation.
Conclusions
This isthe first report linking the use of cayenne pepper ... in the pathophysiology
of this condition [17].
7
The majority of cases with clinical and electrocardiographic signs of acute
coronary events have been diagnosed based on the patency of coronary ... patient was treated with
the calcium antagonist diltiazem. The observed improvement in his clinical and
electrocardiographic findings and the relief of his chest pain after stopping the cayenne
pepper...
...
work and to the best of my knowledge. Data and materials used in the
thesis are real with obvious origins; findings in this thesis are studied
results ofthe writer.
AUTHOR OFTHE THESIS
Ha ... modernization associatedwiththe development
of the knowledge-based economy, the thesis analyses, assesses the situation of
human resources for industry of modernization associatedwiththe development ... the operation of Socio-economic activities to create material wealth and
the spirit of service to society.
With this approach ofthe thesis, the concept of human resources fully reflects
the...
... angiogenesis in the skin of patients with SSc [3].
Angiogenesis is a complex multistep process that is under
the tight control of angiogenesis inducers and inhibitors.
Under normal conditions, the ... transfer of phVEGF
165
[37]. The hypothesis that
VEGF might have dual functions in the pathogenesis of
SSc, with positive effects on the vascular system but with
negative effects on the development of ... other
reasons such as signaling defects or lack ofthe VEGF
receptors flt and flk cannot be excluded withthe present
study, this hypothesis is strongly supported by the fact
that patients without...
... the resorption ofthe calcified cartilage and
subchondral bone in the early phase ofthe disease [18].
Licofelone treatment was shown to reduce the level of
synthesis of cathepsin K in both of ... necrosis
factor-α [26], however, the capacity of licofelone to inhibit the
synthesis of IL-1β [6-8] may explain, at least in part, the effect
of the drug on the synthesis of cathepsin K.
Figure 3
ADAMTS-5 ... [6]; the results of this study
indicated that the drug works through the inhibition ofthe syn-
thesis of IL-1β and MMP-1. The present study aimed to expand
our knowledge about the effect of licofelone...