what hormone is responsible for controlling blood sugar levels
Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
Ngày tải lên :
16/03/2014, 04:20
... carnitine: 1 mm (for standard comparison with
other published data), and a concentration equal to
the K
m
for carnitine of each enzyme (for comparison
between mutants). In this article, we show ... sequence as being responsible for the pecu-
liar kinetic characteristics of this enzyme, acting as a
negative determinant for malonyl-CoA sensitivity.
Asp17 may account, at least in part, for the high
degree ... nat-
urally occurring variation, Glu17, is responsible for both the low malonyl-
CoA sensitivity and high carnitine affinity characteristics of the pig enzyme.
This is the first demonstration that a single...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
Ngày tải lên :
23/03/2014, 07:20
... active conformation, Val371 forms contacts
with neighboring residues that are important for stabi-
lizing the active state (e.g. Asp189, which is part of the
S1 pocket responsible for the binding ... sequence identity of 30–45%), this
position is occupied solely by a valine. This conserved
amino acid is replaced by isoleucine in the Val371Ile
FXI mutant. Interestingly, an isoleucine residue natu-
rally ... the
substrate) [26]. Consequently, substitution of Val371 to
isoleucine might prevent the full development of the
active conformation. This hypothesis is further con-
firmed by the results of FIX proteolytic...
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Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
Ngày tải lên :
23/03/2014, 10:20
... factor that favors lysogeny and is
responsible for primary control of the lambda develop-
mental decision for lysis or lysogeny [4,7–9]. In the
absence of CIII, CII is rapidly degraded by the ATP-
dependent ... However, this proteolysis is much
slower in vitro, because of a lack of chaperone machin-
ery. The in vitro proteolysis requires ATP [14]. We
examined the proteolysis of purified r
32
-C-his (1.2 ... CIII-
mediated inhibition of proteolysis of r
32
by HflB is
unknown.
We tried to address this issue by studying
the effects of CIII and CIIIC on the proteolysis of
Keywords
antiproteolytic activity;...
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Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf
Ngày tải lên :
29/03/2014, 22:21
... synthesis, it might be involved in the stearic
acid incorporation after the de novo synthesis of this
lipid (i.e. the second hypothesis). According to this
hypothesis, previously raised for mammals ... from
the European S. cerevisiae Archive for Functional Analysis
(EUROSCARF) library. BY4742 (MATa; his3D1; leu2D0;
lys2D0; ura3D0) is a wild-type strain and psi1D (MATa;
his3D1; leu2D0; lys2D0; ... strongly that PI is remodeled in microsomal
membranes before being transferred to mitochondria
or, in other words, that Psi1p is located in the micro-
somal membranes. This finding is in agreement...
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Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc
Ngày tải lên :
31/03/2014, 09:20
... The enzyme is responsible for melanization
in animals and browning in plants. As browning in food
products is an undesirable process, there has been a constant
need in food industry for compounds ... (Agaricus bisporus) tyrosinase isoforms by tropolone.
J. Agric. Food Chem. 47, 2638–2644.
8. Kahn, V. & Andrawis, A. (1985) Inhibition of mushroom tyro-
sinase by tropolone. Phytochemistry 24, ... compounds should be
poor substrates for tyrosinase. On the other hand, 3,4-
dihydroxybenzoic acid inhibited the dopachrome forma-
tion, although the exact mechanism of this reaction has not
been investigated...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
Ngày tải lên :
18/02/2014, 18:20
... prior to hydrolysis. The low-affinity state was
observed to be retained immediately post-hydrolysis. Therefore, the dissoci-
ation of phosphate and ⁄ or ADP is likely to be responsible for resetting
of ... of ATP
per se is the ‘power stroke’ for drug translocation, and
that energy obtained from the hydrolysis process is
used to reset the transporter. That ATP binding is
responsible for the shift ... that
ABCG2
R482G
remains in a conformation that contains
a low-affinity binding site for [
3
H]daunomycin imme-
diately post-nucleotide hydrolysis.
Discussion
A precise molecular mechanism for substrate translo-
cation...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
Ngày tải lên :
22/02/2014, 04:20
... hydrolysis), corresponding to that expected for the
F variant. This result is the first evidence for the heterozy-
gous status (M/F) of the individual goat milk analysed.
In addition to this, t ... subsequently distin-
guished after a second amplification which allows discrim-
ination between the alleles on the basis of the f ragment sizes
(Fig. 8 , Step IIA).
In the first step, a 266-bp (265 bp for ... the origin of the a
s1
-CasM allele. This
is, to our knowledge, t he first hypothesis o f a genomic
recombination event to account for genetic polymorphism
at a locus encoding a milk protein.
MATERIALS...
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Tài liệu What it is and How to Prepare pdf
Ngày tải lên :
20/12/2013, 23:15
... healthy adults may be at increased risk for problems.
What Is Avian Flu?
Avian flu, also called bird flu, is a disease found in wild and farm birds. There is a
concern that the bird flu will ... 3. Listen for Information
Stay calm and get as many facts as you can.
ã Listen for reports on the television, radio or Internet.
ã Go to www.pandemicflu.gov
or www.ohiopandemicflu.gov for ... prepare:
1. Make a plan for you and your family at home. Plan for how a pandemic might
affect your work.
2. Prepare an emergency kit of supplies.
3. Listen for information about what to do and where...
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Tài liệu Investigation of Organic Chemicals Potentially Responsible for Mortality and Intersex in Fish of the North Fork of the Shenandoah River, Virginia, during Spring of 2007 ppt
Ngày tải lên :
14/02/2014, 08:20
... (<34 ng/POCIS) NC (<14 ng/POCIS) 37 ng/POCIS 40 ng/POCIS
20 ng/POCIS
Ethopabate NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ... ng/POCIS)
Endosulfan II NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS)
cis-Permethrin
NC ... (<4 ng/POCIS) NC (<4 ng/POCIS) NC (<4 ng/POCIS) NC (<4 ng/POCIS) NC (<4 ng/POCIS) NC (<4 ng/POCIS) NC (<4 ng/POCIS)
Cyromazine NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20...
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