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Báo cáo khoa học: Variants of b2-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature potx
... peptide. Shown are the summed peakareas P (total area of f + s peaks) divided by the marker peakarea M at different time points as a percentage of the initialvalue of P ⁄ M at the onset of the experiments ... heterogeneity. The proton chemical shifts of the alternativeconformer (I2) of cK58-b2m are comparedwith the corresponding values of the nat-ively folded form of cK58-b2m in the graph. The two conformers ... doubling at the loca-tions and to the extent reported in Fig. 9. The features of the pattern of the second conformer resemble the features of a minor monomeric intermediate occurringalong the b2m-refolding...
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Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt
... region.Effect of mutations in the C-terminal region of the RmInt1 IEP on RNA splicing in vivoWe constructed a series of mutants to identify the functional features of the C-terminal region of the RmInt1 ... resi-due at the N-terminus of a-helix a4, the domain Xcontains the conserved amino acid residues HKXRA(RmInt1 residues 388–392) carrying a stretch of basicamino acids. Some of the residues of the ... domain X, apparently unrelated to the C-terminal regions of other group II intron-encoded proteins. Multiplesequence alignments identified features of the C-terminal portion of the RmInt1 intron-encoded...
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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf
... modulating the catalytic properties of the enzyme [19]. To extend the information about the role of the noncatalyticSBD regions and their effect on the C-terminal CD,we further explored the amino ... Whereas the production of ADPGlc via ADPGlcPPase is the first committed step in starch biosynthe-sis, SS catalyzes the elongation of a-1,4-glucans by the transfer of the glucosyl moiety from the ... of the apparent affinity for the sub-strates and Vmax of starch synthase III. The results presented here suggestthat the interaction of the N-terminal starch-binding domains, particularlythe...
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Tài liệu Integrative Medicine and the Health of the Public: A Summary of the February 2009 Summit docx
... causes of death (IOM, 1999). Disconnected and uncoordinated care amplifies the economic burden of the health care system. The costs of U.S. health care are driven in large part by the inefficiencies, ... economic burden of the health care system. The costs of U.S. health care are driven in large part by the inefficiencies, redundancies, and excesses of the current fragmented system and are considered ... NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of...
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Tài liệu DIRECTIVE 2004/39/EC OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL ppt
... authority of the home Member State of the MTF shall, on the request of the competent authority of the host Member State of the MTF and within a reasonable delay,communicate the identity of the members ... Council on the state of the removal of the obstacles which may prevent the consolidation at the European level of the information thattrading venues are required to publish.5. On the basis of the ... to the competent authority of the hostMember State. In the event of a change in the particulars, the competent authority of the home Member State shall inform the competent authority of the...
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Tài liệu A Compilation of the Messages and Papers of the President pdf
... pursuance of the duties of their appointment they have in the course of the late season performed the following surveys and explorations:1. The meridian line of the monument at the source of the St. ... remains of the illustrious son should sleep under the same turfwith those of his distinguished father, one of the signers of the Declaration of Independence; in the wish of the citizens of his ... United States of America in Congress assembled,That the chairs of the President of the Senate and of the Speaker of the House of Representatives be shroudedin black during the residue of the session,...
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Tài liệu Report of the Independent Monitoring Board of the Global Polio Eradication Initiative pptx
... indeed, but areas of deep concern persist. The very best news comes from India. For years, many believed that the challenge of stopping polio transmission in India would be the downfall of the Programme; ... healthcare) but fail to meaningfully set out the many ways in which the Polio Programme can contribute. To the generation that follows, the eradication of polio will not be the end of the timeline. ... will be the beginning. What is the polio footprint? What is the legacy that will arm future programmes? This is what the Polio Programme needs to set out.We ask people in the Programme, ‘What...
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Tài liệu Báo cáo khoa học: An investigation of the substrate specificity of the xyloglucanase Cel74A from Hypocrea jecorina pdf
... sub-contract from The Of ce of Biomass Program, within the DOE Of ce of Energy Efficiency and RenewableEnergy. Tom Desmet holds a fellowship of the Insti-tute for the Promotion of Innovation through ... presumably, contain the sites of O-glycosylation,but we have not identified the specific site(s) or the form of the O-glycans. The CD spectrum of Cel74A looks a lot like that of an unordered protein ... using savuka software provided by O Bilsel(University of Massachusetts Medical School, N. Worces-ter, MA, USA). The midpoint of the transition (Tm)isanapparent value, as the thermal denaturation...
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Tài liệu Proposal for a DIRECTIVE OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on Alternative Investment Fund Managers and amending Directives 2004/39/EC and 2009/…/EC ppt
... protection of the interests of members and others, are required by Member States of companies within the meaning of the second paragraph of Article 58 of the Treaty, in respect of the formation of ... receive the following information before they invest in the AIF, as well as any changes thereof: (a) a description of the investment strategy and objectives of the AIF, all the assets which the ... by the AIFM and communicated in the application. The competent authorities of the home Member State may restrict the scope of the authorisation, in particular as regards the type of AIF the...
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Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc
... Figure 5C shows that the spectra of the sample subjected to compression and decompression are similar to the non-treated sample, even in the case of the M88V mutant. The elution of the samples after ... found with otherdissociated capsid proteins, the lack of elution of the proteins can be explained by non-specific binding of the denatured coat proteins to the gel [34,35]. The elution of some D11N ... promote significant binding of bis-ANS to any of the particles, with the exception of T45S, which bound asmall amount of bis-ANS, increasing, by twofold, the emission of the probe (Fig. 7B). M88V...
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Tài liệu REGULATION OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL doc
... of revocation shall put an end to the delegation of the power specified in that decision. It shall take effect the day following the publication of the decision in the Official Journal of the ... prepare in relation to the qualifying venture capital funds they manage. The report shall describe the composition of the portfolio of the fund and the activities of the past year. Article ... eligible investors and the use of the designation "European Venture Capital Fund" should be sanctioned by the prohibition of the use of the designation and the removal of the venture capital...
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