... The purity of his style, the delicacy of his turns, and the justness of his characters, were all of them beauties which the greater part of his audience were incapable of tasting. Some ofthe ... in the formation of his characters from the observations of Theophrastus, of whom he was a disciple; and Theophrastus, it is known, was not only the disciple, but the immediate successor of ... most of our comedies are of fools so gross, that in my humble opinion they should rather disturb than divert the well-natured and reflecting part of an audience; they are rather objects of charity...
... door the like of that door, and seeing nothing but the mists rolling down the bog, and the mists again, and they rolling up the bog, and hearing nothing but the wind crying out in the bits of ... ofthe house. . . . I was passing below on a dark night the like of this night, and the sheep were lying under the ditch and every one of them coughing, and choking, like an old man, with the ... was, the time the shadow was going up through the glen, and when the sun set on the bog beyond he made a great lep, and let a great cry out of him, and stiffened himself out the like of a dead...
... (Met1)-ONC(M23L) by the addition of AAP, as described in the Materials and methods. Completion ofthe hydrolysis wasconfirmed by the disappearance ofthe (Met1)-ONC(M23L) signal in the MALDI-TOF mass ... MALDI-TOF MS. The addition ofthe protease is considered the zero time point. The relative intensities ofthe peaks from the mass spectrawere used to calculate the fraction of Pyr-ONC (M23L), ... hydrogen bonded to the e-amino group ofthe Lys9 side-chain, which simultaneouslyinteracts with the main phosphate ofthe substrate [ 32] . The closer positioning ofthe N-terminus to the mainprotein...
... Fresno M (20 00) An essential role ofthe nuclearfactor of activated T cells in the regulation of the expression ofthe cyclooxygenase -2 gene in human Tlymphocytes. J Biol Chem 27 5, 23 627 23 635.7 ... transcription factors as the mutation of the CRE site within the COX -2 promoter or the expression of a dominant negative mutant of CREBreduces inducibility ofthe COX -2 promoter [9, 12 14]. The transcription ... tliberma@bidmc.harvard.edu(Received 21 July 20 04, revised 19 January 20 05, accepted 2 February 20 05)doi:10.1111/j.17 42- 4658 .20 05.045 92. xCyclooxygenase -2 (COX -2) is a key enzyme in the production of prosta-glandins...
... Germany.(Received 20 November 20 02, revised 3 February 20 03,accepted 19 February 20 03)Eur. J. Biochem. 27 0, 1567–1577 (20 03) Ó FEBS 20 03 doi:10.1046/j.14 32- 1033 .20 03.03 526 .x sulfhydryl-group ofthe one ... acidic hydrolysis of the Qor proteins suggested the presence ofthe MCD form of the pyranopterin cofactor; the CMP contents ofthe threeenzymes were similar.Keywords: quinoline 2- oxidoreductase; ... respectively. The kinetic parameters were estimated from Hanes plots.Determination ofthe metal contents ofthe Qor proteins,and detection ofthe nucleotide moiety of the molybdenum cofactor The contents...
... apop-totic pathways. Brain Res 916, 23 9 24 8. 20 Bruick RK (20 00) Expression ofthe gene encoding the proapoptotic Nip3 protein is induced by hypoxia. ProcNatl Acad Sci USA 97, 90 82 9087. 21 Guo K, ... Journal 27 8 (20 11) 1341 42 ê 20 10 The Authors Journal compilation ê 20 10 FEBS 137 The proapoptotic member ofthe Bcl -2 familyBcl -2 / E1B-19K-interacting protein 3 is a mediator of caspase-independent ... glutamate-inducedexcitotoxicity.BNIP3 is a BH3-only proapoptotic member of the Bcl -2 family. However, unlike in other members of the Bcl -2 family, the BH3 domain of BNIP3 is notrequired for its death-inducing activity....
... determined by the relation 2 = 27 σ 2 3− 4σ3 2 − 4σ3σ31+18σ1σ 2 σ3+ σ 2 1σ 2 2.Furthermore, the actions of t and ψ are given byt(σ1)=ω 2 σ1t(σ 2 )=−σ 2 t(σ3)=ω6σ3t()=ω 2 andψ(σ1)=ωσ1ψ(σ 2 )=ω 2 σ 2 ψ(σ3)=ω3σ3ψ()=ω3.Proof. ... kernel. The chosen subgroupC3⊆ S1 2 of order 3 provides a splitting of S1 2 → C3; hence S1 2 can be written Annals of Mathematics, 1 62 (20 05), 777– 822 A resolution ofthe K (2) -local ... spectra we will see, then, are EhG 24 2 and EhSD16 2 . The discussion of these and related subgroups of G 2 occurs in Section 1(see 1.1 and 1 .2) . The homotopy groups of these spectra are known....
... disregarding the Way. In observing the Way, one will throw away his own precious life. Thus, in order to preserve theWayoftheSamurai and not to disregard theSamurai Ordinances, I quickly threw away ... parents to the master, and learn everyday politeness and etiquette, the serving of other people, the ways of speech, forbearance and even the correct wayof walking down the street. The elders ... one's unmindfulness oftheWay can be known. Negligence is an extreme thing. The WayoftheSamurai is found in death. When it comes to either/or, there is only the quick choice of death. It is...
... At -the- money, Out -of- the- money The strike price, or exercise price, of an option determineswhether that contract is in -the- money, at -the- money, or out- of- the- money. If the strike price of ... exist. The seller of an option is, in turn,obligated to sell (in the case a call) or buy (in the case of aput) the shares to (or from) the buyer ofthe option at the specified price upon the buyer’s ... Effect Varies The effect of an increase or decrease in the volatility of the underlying stock may be noticed in the time value portion of the options’ premiums. The net effect on thestrategy willdepend...
... Hum Ge ne Ther 20 02, 13:355-365.37. Zaharoff DA, Barr RC, Yuan F: Electromobility of plasmid DNA in tumortissues during electric field-mediated gene delivery. Gene Ther 20 02, 9: 128 6- 129 0.38. ... toincrease the response of melan oma to therapy. The rationale for the use of G3139 is based on the relevantrole of bcl -2 in melanoma cell survival and on the increased sensitivity of this tumor when ... 9: 125 http://www.translational-medicine.com/content/9/1/ 125 Page 2of 10 2 expression was more pronounced (~30% reduction),following the administration of G3139. The treatmentwith G3139/EP combination produced more than a 70%reduction ofthe bcl -2 protein...