was recently identified in human peripheral blood monocytes treated with monocyte chemotactic protein 1 mcp1 and in human monocytederived macrophages stimulated with interleukin il1b these experiments revealed that the gene undergoes rapid and potent
báo cáo hóa học:" Survivin gene levels in the peripheral blood of patients with gastric cancer independently predict survival" doc
Ngày tải lên :
18/06/2014, 15:20
... 0.004
Survivin* 1. 34 1. 14 1. 53 < 0.0 01
HR: hazard ratio; CI: confidence interval; * the HR associated with
Survivin levels indicates the increase of death risk for 10 0-fold
increase in Survivin expression.
... Medicine 2009, 7 :11 1 doi :10 .11 86 /14 79-5876-7 -11 1
Received: 24 August 2009
Accepted: 22 December 2009
This article is available from: http://www.translational-medicine.com/content/7 /1/ 111
© 2009 ... patients'
OS. The hazard ratio (HR) associated with Survivin levels
indicates the increase in risk of death for 10 0 fold increase
in Survivin expression (Table 3).
Since only these four independent...
- 8
- 565
- 0
Tài liệu Báo cáo khoa học: Staphylococcal enterotoxin C1-induced pyrogenic cytokine production in human peripheral blood mononuclear cells is mediated by NADPH oxidase and nuclear factor-kappa B doc
Ngày tải lên :
19/02/2014, 00:20
... superna-
tant fluids of SEC1 -stimulated PBMC in rabbits was in parallel with the
levels of interleukin- 1b and interleukin- 6 in the supernatants. The release
of interleukin- 1b and interleukin- 6, nuclear translocation ... rabbits intravenously injected (1 mLÆkg
)1
) with the supernatant fluids obtained from PBMC (1 · 10
7
cellsÆmL
)1
) treated
for 72 h with the vehicle, SEC1 or SEC1 plus polymyxin B (50 lgÆmL
)1
). ... production
(pgÆmL
)1
)
Fever index (°C)
IL-1b IL-6
Vehicle 12 ± 3 16 0 ± 7 0 .18 ± 0.02 (5)à
SEC1 214 1 ± 5* 32500 ± 510 * 1. 06 ± 0.03 (5)*
PDTC 13 ± 5 10 0 ± 3 0. 21 ± 0.02 (5)
SEC1 + PDTC 17 6 ± 62 5500 ± 210 ...
- 13
- 465
- 0
Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer doc
Ngày tải lên :
22/03/2014, 17:20
... Ruta 1 was evaporated to approximately
10 0 µl, and 2 ml of RPMI medium was added to this. The
plate was further incubated to evaporate the remaining alcohol.
Of this medium 1 ml containing Ruta 1 ... compared with the
control (10 .4%), showing its mitogenic effect on normal
cells. In addition, the MI in H
2
O
2
only -treated B-lymphoid
cells was 7 .1% compared with 14 .4% in cells treated with
Ruta ... in 0.5 ml of a propidium
iodide (PI) solution (50 µg/ml PI, 0 .1% Triton X -10 0, and
0 .1 sodium citrate in PBS). These cells were incubated in PI
solution at 4˚C in the dark for 24 h and then the...
- 8
- 670
- 0
Báo cáo khoa học: Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells doc
Ngày tải lên :
30/03/2014, 04:20
... determined.
Gene name Sequence ID SEB (2 h) SEB (16 h) MK5 91 (2 h) MK5 91 (16 h)
CTAP-III BC028 217 )1. 73 ± 0. 01 )2. 21 ± 0.03 1. 18 ± 0.03 1. 42 ± 0 .10
CTSL NM-0 019 12 6 .13 ± 0.22 4.9 ± 0 .15 )1. 01 ± 0 .10 ... & Suffredini AF
(19 91) Detection of interleukin 8 and tumor necrosis
factor in normal humans after intravenous endotoxin:
the effect of antiinflammatory agents. J Exp Med 17 3,
10 21 10 24.
24 Yan ... believed that the gene analysis
would further complement and validate the inhibitory
effects observed for MK5 91 at a protein level [18 ].
Some of the investigated genes are involved in func-
tions...
- 11
- 470
- 0
Pulmonary tuberculosis associated with increased number and percentage of natural killer and B cells in the peripheral blood pot
Ngày tải lên :
29/03/2014, 03:20
... with the clinical
findings. Peripheral blood subset data of the patients were
compared with a section of the similar data generated previously for
defining the normal range of adult peripheral ... lymphocytes in the peripheral blood.
There was however no difference in the percentages of
CD8 + and cells expressing HLA-DR molecules between
the patients with PTB and normal healthy individuals. ... T-
lymphocyte counts in adults infected with human immunodeficiency
virus through blood and plasma sold in the past in china and in whom
infection has progressed slowly over a long period. Clin. Diagn....
- 5
- 419
- 0
Báo cáo sinh học: "Concomitant detection of IFNa signature and activated monocyte/dendritic cell precursors in the peripheral blood of IFNa-treated subjects at early times after repeated local cytokine treatments" doc
Ngày tải lên :
18/06/2014, 19:20
... stimulus
GO:00 313 47
GO:0045087
GO:004 312 3
GO:0002253
GO:0002252
GO:0050778
GO:0048584
GO:0006954
GO:0009 611
GO:0006952
GO:0048 518
GO:0006950
GO:00 517 04
GO:0006955
GO:0002376
GO:0050896
9.6x10
-3
8.5x10
-3
2.4x10
-3
2.2x10
-3
1. 1x10
-3
2.0x10
-4
4.4x10
-4
5.9x10
-4
9.6x10
-4
2.2x10
-6
7.4x10
-2
3.1x10
-3
1. 3x10
-9
3.3x10
-11
6.3x10
-9
2.2x10
-6
A
B
Figure 4 Functional classification of genes ... locu
s
UBE2L6
BST2
SF3B4
G1P2
IFIT2
IFITM2
SILV
IRF7
NTRK2
TNFSF10
CHERP
NMI
SP 110
STAT1
TRIM22
C1orf29
MYD88
IFI35
IFITM2
LY6E
IFITM3
SERPING1
ADAR
MX1
MX2
GMPR
IFIT1
LIPC
MMP1
CXCL10
OAS1
10 3
28
11 7
3
7
42
13
8
13
36
74
13
10
14
15 9
HBV
Study
Melanoma
Study
PBMC
In vitro
Monocytes
In vitro
Pre IFND Post IFND
252CD14+ IFNDCD14 ... typical IFNa-
induced genes.
CD14
+
/CD16
+
monocytes, coexpressing CD16 and low
levels of CD14, wer e first characterized by Ziegler-
Heitbrock and colleagues in 19 88 [ 41] , and their number
and phenotype/function...
- 15
- 526
- 0
Báo cáo khoa học: Plasmodium falciparum merozoite surface protein 1 Glycosylation and localization to low-density, detergent-resistant membranes in the parasitized erythrocyte pdf
Ngày tải lên :
08/03/2014, 08:20
... findings indicated that [
3
H]GlcN is linked to
serines and [17 ,37,38] threonines [7 ,10 ] and we now show
that O-GlcNAc addition takes place in both the C- and
N-terminal ends of the protein, while the ... linked to the
surface of the protein in a-O-GlcNAc configuration. Two
a-O-GlcNAc sites are indeed predicted in the Ghana,
PngMAD20 and Uganda strain MSP -1 proteins and it is
remarkable that the three ... Uganda vs. Thai-K1 and Wellcome). Such
b-O-GlcNAc sites are not localized in the regions of
homology (387– 413 and 11 00 11 87) within the sequences
of blocks 5 16 of the two dimorphic forms. The...
- 10
- 415
- 0
Báo cáo khoa học: Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90 doc
Ngày tải lên :
16/03/2014, 22:20
... domains, including the postulated
Hsp90-binding and dimerization regions [16 ]. Mutants
with truncations extending into the N-terminal
domain, Cdc37 (1 15 5), Cdc37 (1 12 0), Cdc37 (1 60) and
Cdc37 (1 37), ... mine the identity and location of the nucleotide insertion.
Four mutants obtained contained in- frame insertions
resulting in the insertion of five amino acids into the Cdc37
protein. Stop ... into the Nde1-Xma1 sites of pREP1 and pREP 81 vec-
tors. Similarly, S. cerevisiae CDC37 was amplified from the
plasmid E 119 [30] by PCR and ligated into the Nde1-Xma1
sites of the vectors pREP1...
- 12
- 275
- 0
Báo cáo khoa học: Transcription factor specificity protein 1 (SP1) and activating protein 2a (AP-2a) regulate expression of human KCTD10 gene by binding to proximal region of promoter pot
Ngày tải lên :
30/03/2014, 02:20
... FEBS 11 19
Binding of Sp1 and AP-2a to the corresponding
sites in the promoter of human KCTD10 in vivo
To confirm that Sp1 and AP-2a bind to the authen-
tic endogenous cis-elements in the KCTD10 ... accepted 11 December
2008)
doi :10 .11 11/ j .17 42-4658.2008.06855.x
Potassium channel tetramerization domain-containing 10 gene (KCTD10)
belongs to the polymerase delta-interacting protein 1 (PDIP1) gene ... genomic fragment in the
5¢-flanking region of human KCTD10; and identified
the binding sites of two transcription factors, specific-
ity protein 1 (SP1) and activating protein- 2a (AP-2a),
in the promoter...
- 11
- 409
- 0
báo cáo hóa học:" Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells" pptx
Ngày tải lên :
18/06/2014, 15:20
... provide insight into gene reg-
ulation within tissues, the induction of ABCA1 and
ABCG1 within the spleen, an organ highly enriched in
immune system cells, was compared to induction in
peripheral blood ... lesions
[13 -15 ]. In macrophage, LXR activation results in the
induction of several genes. Among these induced genes
are those encoding the ATP-binding cassette proteins,
such as ABCA1 and ABCG1, which ... vivo with LXR-623, which showed that
ABCA1 and ABCG1 expression was similarly regulated in
human peripheral blood cells. Furthermore, despite the
assumption that monocytes (the circulating macrophage-
Journal...
- 15
- 623
- 0
báo cáo hóa học:" Cyclic changes in gene expression induced by Peg-interferon alfa-2b plus ribavirin in peripheral blood " pot
Ngày tải lên :
18/06/2014, 15:20
... 1 4 98 3.7E+05
15 51 61 1a 0 3 73 1. 8E+06
16 50 78 1a 1 3 99 1. 6E+06
17 60 10 6 1a 1 2 37 4.1E+05
18 45 11 4 1a 1 4 16 1 9.0E+05
19 47 74 1b 1 3 11 7 4.0E+05
20 61 83 1b 1 2 18 1 8.1E+05
... 2 12 7 1. 1E+07
8 42 11 2 1a 1 1 67 7.2E+06
952 78 1a 1 4 71 2.3E+06
10 57 76 1b 0 2 68 7.1E+06
11 59 70 1b 0 3 62 2.4E+06
12 56 10 9 1a 1 4 74 5.8E+06
13 49 11 6 1a 1 2 44 5.8E+06
14 53 90 1b 1 4 ... of these genes
may represent compensatory responses.
SP100 1. 9 1. 7 1. 9 1. 6 1. 6 1. 5 1. 8 SP100 nuclear antigen
SP 110 1. 9 1. 5 1. 9 1. 5 1. 5 1. 5 1. 6 SP 110 nuclear body protein
USP18 7.4 4.9 7.5 5.1...
- 15
- 646
- 0
báo cáo hóa học:" High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia" pot
Ngày tải lên :
18/06/2014, 15:20
... urine total protein. Ann Clin Bio-
chem 19 87, 24(Pt 2) :14 0 -14 4.
Table 3: Proteins as expressed in the gastric cell line but not in AML.
No. Protein name General function Ref.
414 -3-3σ Adapter protein ... of the gel [14 ].
After electrophoresis, the gels were fixed in 50% ethanol,
and 10 % acetic acid for 12 hours.
Silver staining
Proteins were visualized using the silver staining method
employing ... related) was only present in patient C, spot No.
12 1 and 12 2 (TCHTP and variant) was only present in
patient F and G, respectively. Spot 60 (FK506 binding pro-
tein 4) was absent in patient D and...
- 8
- 529
- 0
báo cáo hóa học:" yuDetecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients" pot
Ngày tải lên :
18/06/2014, 15:20
... we
removed the paraformaldehyde by pelleting the cells at
15 00 rpm for 5 min, resuspending them in prechilled
90% methanol, and incubating them on ice for 30 min.
The cells were then pelleted at 15 00 ... The cells were then centrifuged at
15 00 rpm for 2.5 min and washed once with FACS buffer
and 3 times with 1: 3 PermWash (eBioscience). The cells
were stained intracellularly with 5 μL PE-antihuman
FoxP3 ... [43], and Janus kinase 2 [46], and it is uncertain
which of these, either individually or in combination, is
the etiological agent for inducing p-STAT-3 in PBMC.
Alternatively, there may be other...
- 9
- 462
- 0
Báo cáo hóa học: " Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction" ppt
Ngày tải lên :
18/06/2014, 16:20
... Stratifying
the mice based on the day 0 infarct size in the present
study did not, however, influence the interpretation of
the data and all transplanted animals were included in
the final evaluation.
NOD/SCID ... crystals
(QD655, Invitrogen) in cell media (X-Vivo with recom-
binant human SCF, Flt3-L and TPO (all 10 ng/ml)) in
thepresenceof0.1nMprotaminesulphatefor15min
followed by overnight incubation in cell ... [18 ]
and transplanted with QD655 or Feridex750 labeled
cells (2 × 10
6
CD34
+
,1. 6-4 10
5
ALDH
lo
Lin
-
;2.3-
4 10
5
ALDH
hi
Lin
-
)byasingleintravenous(IV)injec-
tion via the tail vein. PBS injected...
- 13
- 506
- 0
Báo cáo sinh học: "Interferon signaling patterns in peripheral blood lymphocytes may predict clinical outcome after high-dose interferon therapy in melanoma patients" potx
Ngày tải lên :
18/06/2014, 19:20
... RP,
Larner AC, Finbloom DS: Interleukin -10 inhibits expression of both
interferon alpha- and interferon gamma- induced genes by suppressing
tyrosine phosphorylation of STAT1. Blood 19 99,
93 :14 56 -14 63.
32. ... fold induction of pSTAT1 in post -treated lymphocytes by the fold induction of pSTAT1 in pre -treated
lymphocytes (post/pre). A median of these ratios was generated (1. 25) using all patients in the ... ned by dividing
the fold change in pSTAT1 post-treatment by the fold
change in pSTAT1 pre-treatment. A median of these
ratios was generated using all patients in the stu dy (n =
14 ) and patients...
- 9
- 369
- 0
- and in several species that have been closely examined
- metallothionein mt was first identified in 1957 by m margosch and b vallee as a cadmium protein from equine kidney cortex in fact
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