utility of mesenchymal stem cell therapy in type 1 diabetes

báo cáo khoa học: "The research on the immuno-modulatory defect of Mesenchymal Stem Cell from Chronic Myeloid Leukemia patients" pdf

Ngày tải lên : 10/08/2014, 10:21

... the “863 Projects” of Ministry of Science and Technology of PR China (No 2006AA02A109 2006AA02A 115 ); National Natural Science Foundation of China (No.305707 71; Beijing Ministry of Science and Technology ... signalling maintains leukaemia- Page 10 of 10 initiating cells in chronic myeloid leukaemia Nature 2 010 , 463(72 81) :676-80 39 Zhao ZG, Li WM, Chen ZC, You Y, Zou P: Immunosuppressive properties of mesenchymal ... 2003, 23(3):6 81- 91 17 Sang-Oh Yoon, Sejeong Shin, Ho-Jae Lee: Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinosito kinase/Akt dependent matrix metalloproteinase-9 expression...

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Báo cáo y học: " Defining human mesenchymal stem cell efficacy in vivo" ppsx

Ngày tải lên : 11/08/2014, 03:20

... 1. 0 1. 47 14 50 51 0.8 1. 29 15 53 30 1. 19 0.78 15 57 47 1. 0 1. 11 1568 47 0.69 1. 12 15 94 28 0.79 1. 17 15 68 45 0 .13 1. 37 Bonfield et al Journal of Inflammation 2 010 , 7: 51 http://www.journal-inflammation.com/content/7 /1/ 51 ... Pharm Des 2005, 11 :3027-3038 doi :10 .11 86 /14 76-9255-7- 51 Cite this article as: Bonfield et al.: Defining human mesenchymal stem cell efficacy in vivo Journal of Inflammation 2 010 7: 51 ... perivascular origin for mesenchymal stem cells in multiple human organs Cell Stem Cell 2008, 3:3 01- 313 Delorme B, Chateauvieux S, Charbord P: The concept of mesenchymal stem cells Regen Med 2006, 1: 497-509...

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Dynamic mechanical stimulation for mesenchymal stem cell chondrogenesis in an elastomeric scaffold

Ngày tải lên : 09/09/2015, 08:12

... static standing, 0 .1 to MPa in walking and a peak of 10 -20 MPa during stair climbing (Fig 11 ) (Eckstein et al., 2005) 30 Fig 11 Magnitude of cartilage deformation with different types of activities ... markers with integrin 1 inhibition in free swelling conditions Fig 32 The distribution and quantification of pSMAD2/3 and pSMAD1/5/8 at week in free swelling samples with integrin 1 inhibition ... of TGF-β/Activin/Nodal Signaling by SB4 315 42…… ……….74 5.2.8 Effect of TGF-β/Activin/Nodal Signaling Inhibition on Integrin 1/ FAK Signaling and BMP/GDP Branch Signaling………………………… … 75 5.2.9 Inhibition...

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Báo cáo y học: " Increased production of viral proteins by a 3''''-LTR-deleted infectious clone of human T-cell leukemia virus type 1" ppsx

Ngày tải lên : 12/08/2014, 04:21

... genes in HTLV1-infected individuals [16 ,27] This might be caused by cellular factors, such as PDZ proteins, inhibiting Tax expression by binding to the PDZ-protein-binding motif in the C-terminal ... for the Promotion of Science, the Japan Leukaemia Research Fund, and Kumamoto University's Centers of Excellence (COE) Program 21 22 References 10 11 12 13 14 15 16 17 18 19 Hinuma Y, Nagata K, ... inactivation of DLG1 augments the Tax-mediated transformation of cells This finding suggests that DLG1 regulates the function of Tax through its PDZ-binding motif [26] HTLV -1- infected cells in...

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basal insulin therapy in type 2 diabetes

Ngày tải lên : 12/08/2014, 20:59

... required insulin therapy within years of followup .15 ,16 Combination Therapy with Insulin In many patients with type diabetes, insulin is ﬁrst used in combination with oral therapy A number of insulin ... and NPH insulin Diabetes Care 20 01; 24:6 31 HOE 9 01/ 2004 Study Investigators Group Safety and efﬁcacy of insulin glargine (HOE 9 01) versus NPH insulin in combination with oral treatment in Type diabetic ... Basal Insulin Therapy in Type Diabetes 2 01 tion of these longer-acting insulin preparations is generally believed to result from variability in the concentration of insulin in the suspension injected...

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Báo cáo y học: "Retraction: Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells" potx

Ngày tải lên : 13/08/2014, 01:20

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Báo cáo y học: " PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line" ppsx

Ngày tải lên : 13/08/2014, 09:21

... Expression of cell- cycle regulatory genes in HTLV-I infected T -cell lines: possible involvement of Tax1 in the altered expression of cyclin D2, p18Ink4 and p21Waf1/Cip1/Sdi1 Oncogene 19 96, 12 :16 45 -16 52 ... [15 ,16 ] Tax1 inhibits several modes of apoptosis [17 ], and stimulates the cell cycle progression in primary T-cells as well as in T -cell lines [18 ,19 ] In addition, in transgenic animals Tax1 induces ... IL-2-independent growth of CTLL-2 cells induced by Tax1 PBM is essential for IL-2-independent growth of CTLL-2 cells induced by Tax1 (A) CTLL-2 is a mouse T -cell line This cell line was cultured in...

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Báo cáo y học: " Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells" potx

Ngày tải lên : 13/08/2014, 09:21

... T -cell lines Figure and primary ATL cells AG490 reduces cell growth of HTLV -1- infected T -cell lines AG490 reduces cell growth of HTLV -1- infected T -cell lines and primary ATL cells (A) HTLV -1- infected ... Stat5 by inhibiting three Jak kinases in HTLV -1- infected T -cell lines Figure HTLV -1- infected T -cell lines and primary ATL cells AG490 inhibits constitutive activation of Jak and Stat in AG490 inhibits ... Stat-activation of HTLV-1infected T -cell lines and primary ATL cells [12 ,14 ] Expression of Stat5 mRNA is induced by HTLV -1 Tax using JPX9 cells [32] Using this cell line, we showed that Tax induced neither...

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Báo cáo y học: "Cost-effectiveness of continuous glucose monitoring and intensive insulin therapy for type 1 diabetes" ppsx

Ngày tải lên : 13/08/2014, 11:22

... Characteristics in Type Diabetes: Wisconsin Epidemiologic Study of Diabetic Retinopathy Archives of Internal Medicine 2004, 16 4 (17 ) :19 17 -19 24 Page of 19 Wu SY, Sainfort F, Tollios JL, Fryback DG, Klein R, ... Care 2005, 28(3): 617 -25 doi :10 .11 86 /14 78-7547-9 -13 Cite this article as: McQueen et al.: Cost-effectiveness of continuous glucose monitoring and intensive insulin therapy for type diabetes Cost Effectiveness ... ADA [1] ESRD 36,370 26,377 47,708 ADA [1] LEA 50 ,15 0 36,5 41 65,798 ADA [1] Nephropathy 20 ,16 1 14 , 614 26,643 ADA [1] Neuropathy 25,075 18 ,226 33,004 ADA [1] Retinopathy 4,956 3,578 6,489 ADA [1] ...

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Báo cáo khoa hoc:" The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes" pptx

Ngày tải lên : 11/08/2014, 07:21

... (10 0) Yes ( 31) (46) (23) 13 (10 0) No 89 (22) (14 ) 41 (10 0) 11 1 (29) 18 1 (48) 86 (23) 21 (38) 25 (45) (16 ) 55 (10 0) 10 5 (29) 17 6 (48) 83 (23) (0) (10 0) (0) (10 0) 12 6 (30) 200 (48) 92 (22) 0.9 91 ... UAE (mg/24 h) 593 .1 (250.0 -15 19.5) 7.0 (4.0 -12 .0) p < 0.0 01 Plasma creatinine (μmol/l) 10 2 (82.0 -13 6.3) 79 (53- 81) p < 0.0 01 GFR (ml/min /1. 73 m2) 66 .1 ± 27.7 87.4 ± 14 .9 p < 0.0 01 ESRD (%male) 24 ... (43) 25 (22) 11 5 (10 0) No Mortality Cardiovascular (CV) death 17 0 ( 51) 77 (23) 46 (47) 23 (23) 98 (10 0) 97 (28) 17 4 (50) 79 (22) 350 (10 0) Yes 14 (40) 15 (43) (17 ) 35 (10 0) 11 2 (29) 18 6 (48) 86...

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Báo cáo y học: "Bilateral dystonia in type 1 diabetes: a case report" pot

Ngày tải lên : 11/08/2014, 19:21

... is mostly observed in type diabetes and cases with type diabetes are extremely rare In the 53 cases reported in the literature, only one case of type diabetes with acute onset of nonketotic hyperglycemia ... difficulties in taking meals for days These movements were observed in both waking and sleep states She presented extremely high plasma glucose (774 mg/dl), hemoglobin A1c ( 21. 2%) and glycated albumin (10 0%) ... as local gamma-aminobutyric acid (GABA) starvation, disinhibition of dopaminergic neurons, local microhemorrhage, microinfarction, demyelination and brain edema [4] Recent imaging analysis has...

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Báo cáo sinh học: " Risk factors in the development of stem cell therapy" pdf

Ngày tải lên : 18/06/2014, 19:20

... somatic cells Science 2007, 318 :19 17 -19 20 Herberts et al Journal of Translational Medicine 2 011 , 9:29 http://www.translational-medicine.com/content/9 /1/ 29 10 11 12 13 14 15 16 17 18 19 20 21 22 ... differentiate in cell types of all three Can differentiate in cell types of all three germ germ lineages lineages Can differentiate in limited cell types depending on the tissue of origin Ability ... counterparts of embryonic stem cells that originate from the inner cell mass of a blastocyst stage embryo The embryonal carcinoma cells replicate and grow in cell culture conditions In 19 81, embryonic stem...

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Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines ppt

Ngày tải lên : 10/08/2014, 05:21

... of the adenovirus major late promoter Genes & development 19 88, 2 :11 36 -11 43 Boyes J, Bird A: DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein Cell 19 91, 64 :11 23 -11 34 ... distinct classes of promoters Proceedings of the National Academy of Sciences of the United States of America 2006, 10 3 :14 12 -14 17 35 Li E: Chromatin modification and epigenetic reprogramming in ... Nusbaum C, Lander ES, Bernstein BE: Genome-wide maps of chromatin state in pluripotent and lineage-committed cells Nature 2007, 448:553-560 Page 13 of 13 doi :10 .11 86 /14 23- 012 7 -17 -64 Cite this article...

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Báo cáo khoa học: Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the 1 level of phosphorylation of IRS1 in type 2 diabetes pot

Ngày tải lên : 07/03/2014, 16:20

... 1. 1 1. 8 0.6–0.7 0.9 1. 1 0 .1 0.2 1. 1 1. 8 0.6–0.7 0.3–0.4 0.02–0.03 1. 1 1. 8 1. 8–2.0 0.6–0.7 0 .1 0.2 1. 1 1. 8 1. 8–2.0 0.6–0.7 0 .1 0.2 1. 1 1. 8 1. 8–2.0 0.6–0.7 0 .1 0.2 1. 1 1. 8 1. 8–2.0 0.6–0.7 0 .1 0.2 ... Epinephrine-induced insulin resistance in man J Clin Inv 65, 717 –7 21 34 Rizza RA, Mandarino LJ & Gerich JE (19 82) Cortisolinduced insulin resistance in man: impaired suppresion FEBS Journal 272 (2005) 14 1 15 1 ... acids inhibit insulin FEBS Journal 272 (2005) 14 1 15 1 ª 2004 FEBS Insulin resistance in human adipocytes 41 42 43 44 45 activation of insulin receptor substrate -1 (IRS -1) -associated phosphatidylinositol...

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báo cáo hóa học:" Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures" potx

Ngày tải lên : 18/06/2014, 15:20

... References 10 11 12 13 14 15 16 17 18 19 Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj, Horwitz E: Minimal criteria for defining multipotent ... possibility of using stem cells for regenerative medicine has opened a new field of investigation to find the best sources for obtaining multipotent stem cells, in particular through non-invasive ... cells 1B) Skeletal myosin expression in muscle control and in the induced hFTs cells 1C) Myosin band observed in the muscle control and in the induced hFTs cells by Ponceau S membrane dyeing 1D)...

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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) ppt

Ngày tải lên : 07/07/2014, 01:20

... Sources of Stem Cells for Tissue Repair Different types of stem cells include embryonic stem (ES) cells, umbilical cord blood stem cells, organ-specific somatic stem cells (e.g., neural stem cells ... numbers of specific cell types, minimizing the risk of tumor formation or proliferation of inappropriate cell types, ensuring the viability and function of the engrafted cells, overcoming immune ... brain Substantial efforts have therefore been devoted to obtaining more pluripotent stem cell populations, such as bone marrow mesenchymal stem cells (MSCs) or adipose stem cells, for use in...

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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 2) pps

Ngày tải lên : 07/07/2014, 01:20

... of a variety of different cell types, including ES cells, bone marrow stem cells, endothelial stem cells, and adipose stem cells Bone marrow stem cells in particular have been examined in clinical ... for cell replacement have been considered (Fig 67 -1) : (1) injection of stem cells directly into the damaged organ or into the circulation, allowing them to "home" into the damaged tissue; (2) in ... desired cell types In addition to these strategies for cell replacement, the ex vivo or in situ generation of tissues provides an alternative means of tissue engineering (Chap 69) Stem cells are...

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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 3) pot

Ngày tải lên : 07/07/2014, 01:20

... development of dyskinesia Transplantation of stem cell derived dopamine-producing cells offers a number of potential advantages over fetal transplants, including the ability of stem cells to migrate ... gastrointestinal precursor cells may be candidates for cell- based therapy of diabetes Nervous System Neural cells have been differentiated from a variety of stem cell populations Human ES cells ... Potential sources of stem cells include endogenous liver stem cells (such as oval cells), ES cells, bone marrow cells, and umbilical cord blood cells Although a series of studies in humans as well...

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