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When Someone You Love Is Being Treated for Cancer pptx
Ngày tải lên :
06/03/2014, 01:20
... guilty is a common reaction for caregivers You may worry that you aren’t helping enough, or that your work or distance from your loved one is getting in the way You may even feel guilty that you’re ... Caring for Your Body You may find yourself so busy and concerned about your loved one that you don’t pay attention to your own physical health But it’s very important that you take care of your ... can help you keep your body healthy Finding at least 15-30 minutes a day to exercise may make you feel better and help you manage your stress ■ Make time for yourself to relax You may choose...
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Báo cáo y học: "JNK1 is not essential for TNF-mediated joint disease" doc
Ngày tải lên :
09/08/2014, 06:22
... toluidine blue for tartrate-resistant acid phosphatase (TRAP) activity TRAP staining was performed as previously described [13] For immunohistochemistry, deparaffinized, ethanol-dehydrated tissue sections ... joint disease Of interest, arthritis in hTNFtg mice is directly induced by overexpression of TNF, a potent trigger of the JNK pathway Thus, it is surprising that even if disease is caused by the ... destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis Arthritis Res 1999, 1:81-91 Kallunki T, Su B, Tsigelny I, Sluss HK, Derijard B, Moore G, Davis R,...
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Báo cáo y học: " Neutrophil cannibalism – a back up when the macrophage clearance system is insufficient" pot
Ngày tải lên :
12/08/2014, 16:20
... the activity of the pannecrosis marker LDH (Figure 1B) In the tissue, a patchy neutrophil-rich inflammatory pattern was confirmed by histological (H&E) analysis of the lung parenchyma (for a closer ... macrophages also displayed signs of necrosis, revealed by chromatolytic nucleus and electron lucent cytoplasm # LDH activity Discussion # * # * Control 12 24 36 48 60 72 It is previously well known ... thereby acting as a back up system stepping in when the macrophage system is exhausted This suggestion is supported by a study exploring the effects of ozone on airway epithelial cells in vitro...
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Báo cáo y học: "The HIV-1 Rev/RRE system is required for HIV-1 5’ UTR cis elements to augment encapsidation of heterologous RNA into HIV-1 viral particle" ppsx
Ngày tải lên :
13/08/2014, 01:21
... packaging system may comprise the synergistic influences of the Rev/RRE system and cis elements from the 5’ UTR, as well as nucleocapsid protein Considering this possibility, we sought to directly characterize ... (Kodak), or by phosphorimager (Molecular Dynamics Storm System) Page 15 of 17 Western Blot Analysis Cytoplasmic and total cell lysates were resolved by standard denaturing SDS-PAGE analysis on 10% ... Rev/RRE system is required for the 5’ UTR cis elements to mediate efficient RNA encapsidation We have demonstrated that the Rev/RRE system is a part of the encapsidation mechanism However, it is well...
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Báo cáo y học: "The system is broken" pps
Ngày tải lên :
14/08/2014, 16:21
... are this tight, generosity of spirit is in danger of being replaced by unenlightened self-interest Every funded proposal now is a direct threat to one’s own grants being funded This mentality inevitably ... quality, the system is broken But I don’t think it’s broken beyond repair, at least not yet Next month, I’ll tell you how I think it can be fixed reviews But I think it’s equally discouraging for ... success rate for first-timers.) A drop in success rate of 50% is nothing to be happy about But the number that really matters for peer reviewers is the percentile ranking, because this is what the...
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Báo cáo y học: "Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units"
Ngày tải lên :
25/10/2012, 10:35
... C-reactive protein level for comparison of systemic inflammatory response syndrome and infection (P 10% immature forms Sepsis is a SIRS associated with the presence of an infectious process Severe sepsis is a sepsis associated with organ dysfunction, hypoperfusion, or hypotension (systolic blood...
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Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"
Ngày tải lên :
03/11/2012, 10:52
... specificity for providing cut-off values, as previously described [1] The null hypothesis was rejected at the 0.05 level in all analyses Statistical analysis Results Statistical analyses were performed ... could negatively influence clinical disease in ALS Thus our study for the first time tentatively supports the hypothesis that a mechanism thorough which abnormal metabolism may ultimately influence ... Immunocytochemistry For semiquantitative assessment of Vgf in spinal cord motorneurons, immunohistochemistry was performed as previously reported [21] with minor modifications Briefly, spinal cord tissue...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
Ngày tải lên :
22/02/2014, 04:20
... elsewhere [18] Enzymatic hydrolyses Trypsin (Boehringer Mannheim) hydrolysis was carried out in 0.4% NH4HCO3, pH 8.5, at 37 °C, for h, in a substrate/enzyme ratio of 50 : (w/w) Dephosphorylation with ... phosphatase hydrolysis), corresponding to that expected for the F variant This result is the first evidence for the heterozygous status (M/F) of the individual goat milk analysed In addition to this, the ... yielded, in polyacrylamide gel at pH 8.6, by the new as1-Cas phenotype, subsequently shown to be a heterozygous M/F (M being the new variant), in comparison with two reference phenotypes AA (lane...
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Báo cáo khoa học: Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity docx
Ngày tải lên :
07/03/2014, 05:20
... H CO2 – O O O OH Scheme Proposed proton relay system Such a proton relay system is attractive for several reasons The enzyme initiates catalysis by ‘separation’ of an electron and a proton, both ... protonation of His106, such that the enzyme is ready for the next substrate turnover In this mechanism, His106 plays a central role, supported by structural evidence that this residue has some conformational ... This species is known to form after the substrate binds to the reduced FMN–enzyme binary complex [9] but before EPSP undergoes transformation to the product [18,19] This species is formed very...
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
Ngày tải lên :
17/03/2014, 23:20
... are ubiquitinated, Cbl is a potential E3 ligase responsible for ubiquitination of Ruk isoforms This hypothesis is currently under investigation The discovery of Ruk isoform ubiquitination in ... Ettenberg, S.A., Katz, M., Tsygankov, A .Y. , Alroy, I., Lavi, S., Iwai, K., Reiss, Y. , Ciechanover, A., Lipkowitz, S & Yarden, Y (1999) Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression ... proteasome- mediated proteolysis, causing an accumulation of proteins that are usually degraded by this pathway [22] In contrast to lactacystine, which is a highly specific proteasomal inhibitor...
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Báo cáo Y học: ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) pdf
Ngày tải lên :
24/03/2014, 04:21
... S U LT S P70ik3-1 is phosphorylated by cyclin A/cdk2, cyclin E/cdk2, cyclin A/cdk3 or cyclin E/cdk3 which is produced in the baculoviral system We initially tested a hypothesis that p70ik3-1 might ... which is phosphorylated by cyclin A/cdk2 [16] Site-directed mutagenesis procedures and the two-dimensional peptide mapping analysis have established that Ser274 in p70ik3-1 is phosphorylated by both ... phosphorylating activity of ik3-1 increased only in lysates from cells where cyclin A and wild-type cdk3, not cdk3 dn, were expressed, supporting the theory that cyclin/ cdk3 actually phosphorylates...
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Báo cáo Y học: The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking pdf
Ngày tải lên :
31/03/2014, 08:20
... hyperinsulinaemic hypoglycaemia of infancy The disease is autosomal recessive and is characterized by profound neonatal hypoglycaemia and Fig Analysis of channel subunit trafficking using surface biotinylation ... putatively immature and maturely glycosylated forms Two bands were also sometimes observed for Kir6.2, the smaller band possibly representing a proteolytic fragment or a partially processed form ... Bleeds were assayed for activity using an antibody capture assay [16] and bleeds showing reactivity were affinity purified Kir6.2 antisera to the C-terminus of the channel and myc hybridoma cells...
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lessons in grid computing the system is a mirror
Ngày tải lên :
01/06/2014, 10:38
... be Core, for his encouragement, in so many ways Thornton May for the humor and humanity he brings to our industry, for his relentless pursuit of Thinking Differently, and for his manyfaceted ... writer and [this theory] demonstrates that you are a visionary in our industry!” Steve Yatko, Head of IT R&D, Credit Suisse First Boston (NYC) Lessons in Grid Computing: The System Is a Mirror ... Computing: The System Is a Mirror Stuart Robbins Lessons in Grid Computing Additional praise for Lessons in Grid Computing: The System Is a Mirror “I really like the storytelling format for communicating...
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Báo cáo y học: "Expert consensus on hospitalization for assessment: a survey in Japan for a new forensic mental health system" pot
Ngày tải lên :
09/08/2014, 01:21
... Psychiatry 2008, 20:527-534 Nakatani Y: Psychiatry and the Law in Japan History and Current Topics Int J Law Psychiatry 2000, 23:589-604 Tsuchiya JK, Takei N: Focus on psychiatry in Japan Br J Psychiatry ... are deeply grateful to the Japanese forensic mental health experts who participated in this research study by mail This survey was supported by a Page 10 of 11 grant to YI from the Ministry of Health, ... of Psychiatry, Chiba University Hospital, Chiba, Japan 2Division of Law and Psychiatry, Chiba University Center for Forensic Mental Health, Chiba, Japan 3National Center Hospital of Neurology and...
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Báo cáo y học: "DEK binding to class II MHC Y-box sequences is gene- and allele-specific" pptx
Ngày tải lên :
09/08/2014, 01:23
... significantly diminishes transcriptional activity [33], is a component of the so-called susceptibility haplotype for autoimmune disease The DQA1*0501 allele is strongly associated with early-onset pauciarticular ... domain, We thank W Szer for human anti-DEK serum, J Ting for anti-NF-YA antibody, and D Glass for multiple helpful discussions This work was supported by grants from the Arthritis Foundation Michigan ... dithiothreitol, 0.5 mm phenylmethylsulfonyl fluoride, 20% glycerol) containing stepwise decreasing concentrations of urea (6 M for hours, M for hours, M for hours, no urea for 12 hours) R233 ...
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Báo cáo y học: "Giantin is the major Golgi autoantigen in human anti-Golgi complex sera" pptx
Ngày tải lên :
09/08/2014, 01:23
... transmembrane domain It is not clear why and how the immune system is able to recognize or target these proteins because it is generally thought that the immune system is not exposed to intact ... One possible explanation is that they may be surface structures represented on cytoplasmic organelles that are recognized as foreign by the immune system in aberrant disease states associated ... that is exposed to the immune system in aberrant disease states associated with unregulated cell death (apoptosis and necrosis) resulting from injury or infection, and defective clearance of dying...
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Báo cáo y học: "Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease" ppsx
Ngày tải lên :
09/08/2014, 01:23
... then isolated by FACS (MoFlo; Cytomation) The purity of the cells was greater than 99% Generation of cytotoxic T lymphocyte lines (mixed lymphocyte culture) Generation of primary alloreactive cytotoxic ... and 50 µM 2-mercaptoethanol) CTLs were used on day for cytotoxicity assays and restimulated on day Restimulation for secondary MLC was performed by incubating CTLs derived in vitro (5 × 104/ml) ... In our hypothesis a specific antigen is not required, leaving room for a multicausal hypothesis on the pathogenesis, including T cells of any specificity Available online http://arthritis-research.com/content/6/5/R433...
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Báo cáo y học: "CXCL12 is displayed by rheumatoid endothelial cells through its basic amino-terminal motif on heparan sulfate proteoglycans" ppsx
Ngày tải lên :
09/08/2014, 07:20
... fully automated peptide synthesizer using Fmoc (N-(9-fluorenyl)methoxycarbonyl) chemistry as described previously [17,18] Selective biotinylation at the carboxy-terminal position was achieved by ... cells and lymphocytes Indeed, CXCL12 is constitutively displayed by endothelial cells (ECs) in the bone marrow and secondary lymphoid organs, where it seems to be produced by nearby osteoblasts, ... intensity of the negative control Statistical analysis was performed with Student's t test Results matoid labelling of CXCL12/HSPGs (OA) synovial tissues Double arthritis (RA) and osteoarthritisand...
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Báo cáo y học: " What is MRI bone oedema in rheumatoid arthritis and why does it matte" ppt
Ngày tải lên :
09/08/2014, 08:23
... fibroblast-like cells, and travel to the synovial membrane where they might appear as type B synoviocytes and promote synovitis [23] Alternatively, they could travel via the systemic circulation to the subchondral ... ankylosing spondylitis, before and after successful therapy with infliximab: Evaluation of a new scoring system Arthritis Rheum 2003, 48:1126-1136 Hoy G, Wood T, Phillips N, Connell D: When physiology ... Research & Therapy Vol No McQueen and Ostendorf in vascular tissue [28] An example from a patient with a year history of RA is shown in Figure Finally, animal studies are emerging to clarify the role...
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