understanding molecular pathogenesis the biological basis of human disease and implications for improved treatment of human disease
The Biological Basis of Nursing: Clinical Observations ppt
... from the left side of the heart to the tissues and back to the right heart, and a pulmonary circulation from the right side of the heart to the lungs and back to the left heart (Figure 2.4) The ... expansion of the vessel for the brief moment that the wave of pressure passes The pressure wave is caused by contraction of the ventricles on the left side of the heart forcing blood into the arteries ... part of the body to another is vital to the very existence of the individual The blood has the task of transporting: water and nutrients from the digestive system to the cells; oxygen from the...
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a means to an end the biological basis of aging and death apr 1999
... length of human life, according to the Greeks, was in the hands of the Fates, or Moerae These three sisters, daughters of the Goddess of the Night, measured out the beginning, the middle, and the ... somewhat slowly for one or two cell divisions, at the rate of the mother, before rebounding to the more rapid replication rate of a younger cell Daughters of younger mothers, on the other hand, begin ... percent of what it was at the end of the nineteenth century These factors still compromise the survival of women in some parts of the world T h e reason for the longer average lifespan of women...
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báo cáo hóa học:" Gender and sexuality: emerging perspectives from the heterosexual epidemic in South Africa and implications for HIV risk and prevention" pdf
... connection? And what are the implications of these for HIV risk, prevention and care? This paper seeks to move beyond the epidemiology and the measurement of behaviours and associations and enable ... 43% of men and 57% of women had ever tested for HIV, and 20% of men and 29% of women said they had done so in the previous year [2] There is evidence from services in multiple settings, and even ... complex web of processes that extend into the organization of private life and cultural arrangements [21] Thus, tenets of culture and religion and, for example, the operation of the legal system,...
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Báo cáo y học: "Carpal tunnel syndrome and the "double crush" hypothesis: a review and implications for chiropractic" pps
... regions of the spine or between spinal and extremity lesions It also allows a rationale for the use of spinal and extremity manipulation, myofascial therapy, therapeutic exercises, and other treatments ... damage All of these researchers claimed findings supportive of the double crush hypothesis, and they have been cited by other researchers and chiropractors as evidence of validity of the syndrome ... pain in the neck and upper back, pain radiating into the left arm, numbness and paresthesia of the left hand, and palpatory tenderness, muscle spasm, and facet joint hypomobility of the cervical...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... neurodegenerative disease Synthesis and secretion of GIF in the brain Cellular and temporal localization of GIF synthesis Whilst the MT1 and MT2 isoforms are ubiquitously synthesized throughout ... remains no clear consensus on the role of GIF in the pathogenesis of AD, and therefore we will briefly review some of the current thoughts on the role of GIF in AD There are numerous pathological hallmarks ... conditions [22] In the traumatically injured brain, however, the synthesis of MT1 and MT2, as well as the synthesis of GIF, are up-regulated by reactive astrocytes in the vicinity of the lesion [23]...
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Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc
... membrane and mediate interactions with the cytoskeleton and with signaling molecules On the basis of extensive searches of the human and mouse genomic sequences, it is now known that 18 a-subunits and ... integrin conformation and biological function For example, only N-glycans located on either the b-propeller of a5 [55] or the I-like domain of b1 or b3 [68] contribute to the regulation of integrin ... for b4) The N-terminal domains of the a- and b-subunits associate to form the integrin headpiece, which contains the extracellular matrix (ECM) binding site The C-terminal segments traverse the...
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GENOMIC DISORDERS The Genomic Basis of Disease doc
... cell anemia is molecularly distinct, and since Watson and Crick's (3) elucidation of the chemical basis of heredity, the molecular basis of disease has been addressed in the context of how mutations ... or required further explanation of the need for their samples I often thought of the irony of the situation At these reunion parties, Dr Garcia would oversee the administration of the electrical ... with the arrowheads representing the short, direct repeats formed at the point of insertion The left half of Alu contains the A and B boxes of the RNA polymerase III promoter The two halves of the...
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Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
... immunohistochemistry (data not shown) As the activity difference was small, the difference in intensity of the bands for the protein and the mRNA were faint Effects of inhibitors of cGCS and GR on primary cultured ... order of band intensities matched the levels of enzymatic activity A Northern blot analysis of total RNAs extracted from the same tissues showed some inconsistent results between the protein and the ... investigate the contribution of de novo synthesis and the recycling of GSH to the intracellular glutathione pool, the Ó FEBS 2002 1574 T Kaneko et al (Eur J Biochem 269) Fig GR activity and the protein...
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Báo cáo khoa học: Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues ppt
... with the TMDs in the outward-facing conformation The authors of both ABCG2 studies acknowledged the limitations of the models and that further refinement and authentication were required [65,66] The ... the sign of the distance change was the same as that observed in the three structural states of Chang, and the magnitudes of distance changes for three of the four pairs of residues for which data ... to a structural understanding of multidrug binding The structure is comparable in terms of the fold and the domain–domain interactions to the structures of MsbA and Sav1866 Furthermore, a cavity...
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Báo cáo khoa học: The structural basis of calpain behavior pptx
... questions are raised by these molecular studies What is the correlation between the in vitro and in vivo Ca2+ requirements for calpain activity? How the two isoforms target their specific substrates ... and oscillations of [Ca2+], in particular those involving specific phosphorylations of calpastatin, calpains and targets The following Minireviews develop three themes on the role of calpain and ... The structural basis of calpain behavior Y Benyamin two parts, DIIa and DIIb, come closer together, with concomitant release of constraints between the domains (large arrows) This active conformation...
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Báo cáo khoa học: "The Linguistic Basis of a Mechanical Thesaurus " doc
... equivalences The autonomy thus acquired by the lexis of the target language allows the thesaurus stage of the dictionary to be the same for one target language whatever the source language, and at the ... from the description of a finite number of languages ) avoids the necessity of the comparative (source-target) identification of word (and other grammatical) categories The word class of the target ... adverb formed from adjective), of which the occurrence is determined by the LPI The features determining the occurrence of these forms are grammatical features of the determining word; they are...
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Understanding Tuberculosis – Deciphering the Secret Life of the Bacilli Edited by Pere-Joan Cardona doc
... the DNA strands The wealth of information on the genomics of M tuberculosis strains present in the world today, coupled with our understanding of the co-evolution of M tuberculosis with its human ... diagnosis and treatment Given the 38 Understanding Tuberculosis Deciphering the Secret Life of the Bacilli burden to public health and the complexity of the disease, an effective control of tuberculosis ... capable of subverting the immune response and persisting as a latent form within an individual and for millennia within the human population Despite the availability of chemotherapy and the continued...
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integrated buildings - the systems basis of architecture
... Wholeness and the Implicate Order, 1980) Think of these two aspects as the domain and the realm of architecture and compare them to the two “wings of the library.” Structural equilibrium and air-conditioning ... to further the systems basis of architecture: function as the foundation of design and industrial standardization as the basis of construction The Bauhaus sought to close the gap between the progress ... the relations which the facts have with one another — the whole they form and fill, not with their parts In place of the arithmetic of nature, we now look for her geometry: the architecture of...
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báo cáo hóa học:" Summary of the primer on tumor immunology and the biological therapy of cancer" ppt
... signaling processes The ligation of VEGFR-2 by the majority of VEGF isoforms triggers the proliferation, migration and survival of endothelial cells, which in tumors form the framework of immature new ... in the formation and maintenance of tumor vasculature and the progression of cancer VEGF and PDGF bind their corresponding receptors to trigger receptor autophosphorylation and the initiation of ... role of cytokines in cancer therapy; and evaluate the foundation and methods for clinical trials of biologic/immunologic therapies Authors' contributions YL and SL drafted the summary, and contributed...
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Báo cáo hóa học: " Viable chimaeric viruses confirm the biological importance of sequence specific maize streak virus movement protein and coat protein interactions" pdf
... K K The fitness of each of the chimaeras and their parental viruses is summarized in Figure 4, which shows the average area under the disease progress curve (AUDPC) and symptom severity for each ... The chimaera comprising both MSV-Kom mp and cp exchanged into the MSV-Set genome showed the highest AUDPC of all the chimaeric constructs, achieving 80% and 85% of the AUDPC figures of KNco and ... determinants of pathogenicity in maize resided in the MSV movement (MP) and coat protein (CP) genes Among the bipartite begomoviruses pseudorecombination of A and B components has formed the basis of many...
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UNDERSTANDING TUBERCULOSIS – DECIPHERING THE SECRET LIFE OF THE BACILLI ppt
... the DNA strands The wealth of information on the genomics of M tuberculosis strains present in the world today, coupled with our understanding of the co-evolution of M tuberculosis with its human ... diagnosis and treatment Given the 38 Understanding Tuberculosis Deciphering the Secret Life of the Bacilli burden to public health and the complexity of the disease, an effective control of tuberculosis ... capable of subverting the immune response and persisting as a latent form within an individual and for millennia within the human population Despite the availability of chemotherapy and the continued...
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Báo cáo toán học: "The cluster basis of Z[x1,1, . . . , x3,3]" potx
... On the other hand, for each index , and for i ∈ I and j ∈ J , we have that row i and column j of the matrix φ(z ) both sum to The definition of the map φ thus implies that row and column sums of ... Observations 3.3 and 3.9 give a unique formula for Z, and if P is of the first form listed in (20), then Observations 3.9 and 3.11 give a unique formula for Z Now to each of the formulas φ(Z) = ... Observations 3.3 and 3.7 give a unique formula for Z, if P is of the first form listed in (18), then Observations 3.7 and 3.11 give a unique formula for Z, if P is of the first form listed in (19), then Observations...
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Báo cáo y học: "Introducing Arthritis Research & Therapy’s 10th anniversary issue, ‘The Scientific Basis of Rheumatology: A Decade of Progress’" pdf
... explore disease at the cellular and molecular levels Specific rheumatic diseases Developments in the scientific understanding of systemic lupus erythematosus are the focus of the contribution of Ardoin ... immunological and nonimmunological basis of disease and the implications for future treatment options The Scientific Basis of Rheumatology: A Decade of Progress should provide the reader with ... molecular- based therapy Szekanecz and Koch [4] review the crucial involvement of the vasculature in inflammatory rheumatic diseases, including the role of the vasculature in atherosclerosis and increased...
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Báo cáo khoa hoc:" Statistical methods and the subjective basis of scientific knowledge" pps
... because the history of scientific theories is the history of the abandonment of old hypotheses and of the keeping of the newly formulated ones For example, when a law f (x, B) derived from theoretical ... manner of contrasting the hypotheses r and the conclusion about the value of r is subjective the rules =- r ; - OPTIMUM ESTIMATION We shall now examine another aspect of the question of the rule of ... posing the rule of the most probable value: choose the hypothesis i B having the largest posterior probability, with the risk of error given by the sum of the probabilities of the hypotheses...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25