tses nonconventional pathogens and the safety of human plasma derived therapeutics
epistemology and the psychology of human judgment dec 2004
Ngày tải lên :
10/06/2014, 22:00
... gets the benefits of both the main effect of D and the main effect of E—then the interaction of D and E is monotone If, however, Sam gets the main effects of both plus an extra benefit, then the ... excellent, or better than any of the alternatives If our theory and the theories of SAE are theories of different epistemological categories, one might wonder whether they can conflict Perhaps by ... the world 18 Epistemology and the Psychology of Human Judgment The second component of a healthy epistemological tradition is theory We take theory and application to be mutually informing and...
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natural-born cyborgs minds technologies and the future of human intelligence apr 2003
Ngày tải lên :
11/06/2014, 00:24
... of the key environments in which this work formed and developed These include the School of Cognitive and Computing Sciences (and especially the Interact Lab) at the University of Sussex, UK; the ... Space The year is 1960 The pulse of space travel beats insistently within the temples of research and power, and the journal Astronautics publishes the paper that gave the term “cyborg” to the ... bypass, rather than penetrate, the old biological borders of skin and skull To see what I mean, let us return to the realms of the concrete and the everyday, scene-shifting to the flight deck of a...
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yale university press doctor dolittles delusion animals and the uniqueness of human language aug 2004
Ngày tải lên :
11/06/2014, 14:43
... in that these bees both dance and understand the dances of others The situation is different for queens and drones, who not dance but understand the dances— at least to the extent that these indicate ... always to the here and now the attitude or the internal state of the animal doing the signaling Even rather rich systems devised and used by humans share this limitation, to the degree that they are ... animals and what they not do, what they can and what they cannot Is it true that they really can learn all of what seem to be the essential structural properties of a human language? Most of these?...
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Báo cáo y học: "GWASs and the age of human as the model organism for autoimmune genetic research" doc
Ngày tải lên :
09/08/2014, 20:21
... levels of risk to SLE There is an approximately twofold increase in the level of risk between carriers of the highest and lowest risk haplotypes Second, candidate genes from a region of LD can ... critical, as the region of LD surrounding the associated SNP often contains more than one gene (although often there is one likely candidate gene from the known biology) A region of LD includes ... insertion/deletion variant of exon 6, and a variant in a conserved poly(A)+ signal sequence that alters the length of the 3’ untranslated region and stability of IRF5 mRNAs [30] Haplotypes of these three variants...
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Báo cáo y học: " High efficient isolation and systematic identification of human adipose-derived mesenchymal stem cells." ppsx
Ngày tải lên :
10/08/2014, 10:20
... characterized by the minimal RNA content and uniform DNA content The results of the study were expressed as mean ± standard error, and statistical comparisons were made using the two-sided Student’s ... in the log phase of the 3rd passage was 24.8 hours There was no significant difference in the growth rate among different passages (Figure 3A) The DNA content was analyzed by FACS Calibur and the ... droplets appeared in part of the cells (Figure 4A) The size of lipid droplets increased after two weeks, and most of the differentiated cells showed red lipid droplet throughout the cytoplasm (Figure...
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Báo cáo y học: "Use of a multi-virus array for the study of human viral and retroviral pathogens: gene expression studies and ChIP-chip analysis" pot
Ngày tải lên :
13/08/2014, 13:20
... listing the identity of the PCR primers used for the production of the amplicons, their exact coordinates on the genomes, the sizes of the probes generated and the success of the amplification Also ... hybridization to other viral amplicons or the majority of the human amplicons, demonstrating the specificity of the immunoprecipitation and hybridization Following induction of viral gene expression and anti-P-H3 ... on the array, the geometric mean of the measured fluorescence intensities was calculated for both the experimental and control and the ratio of these was used as a scaling factor to adjust the...
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Báo cáo y học: "Human toxoplasmosis and the role of veterinary clinicians"
Ngày tải lên :
03/11/2012, 11:06
... with the human immunodeficiency virus Clin Infect Dis.1994;18:14-24 Han K, Shin DW, Lee TY, et al Seroprevalence of Toxoplasma gondii infection and risk factors associated with seropositivity of ... where the consequences of infection can be very severe, while the risk of living with one’s beloved cat is practically nill References Angulo FJ, Glaser CA, Juranek DD et al Caring for pets of immunocompromised ... women in Korea J Parasitol 2008; 94: 963-965 Grant S and Olsen CW Preventing zoonotic diseases in immunocompromised persons: the role of physicians and veterinarians Emerg Infect Dis 1999; 5: 159-163...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
Ngày tải lên :
19/02/2014, 06:20
... and quantitative real-time RT-PCR, the locations of the primers DN)105 and DN)9 used in ChIP assays, the locations of the primers DN+232 and DN+254 utilized in 5¢-RACE, and the locations of the ... in fragments F and I The number at the right of each RT-PCR product represents the length of the product The scheme also shows the location of the reverse primer DN+89 used in another starting ... numbers over the diagrams indicate the position of the corresponding nucleotides relative to the translation start site, and the numbers in parentheses below the diagram show the position of the corresponding...
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Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
Ngày tải lên :
20/02/2014, 02:21
... consequence of the mutagenic replacements Effects of the His120Asn and His145Asn mutations on the affinity of metal binding to arginase II To further examine the effects of the His120fiAsn and His145fiAsn ... electrostatic repulsion between the a-carboxyl group of the amino acid and the introduced aspartic residue at position 149 On the other hand, as agmatine lacks the a-carboxyl group, there would be no impediment ... between the active sites of this enzyme and arginase I In spite of the relatively low agmatinase activity of the Asn149Asp variant, it is clear that the interactions of arginase II with l-arginine and...
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Báo cáo khoa học: Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme–albumin doc
Ngày tải lên :
06/03/2014, 01:20
... [20]: koff ẳ koff2ị ẵibuprofen=K2 ẵibuprofenị ỵ koff3ị ẵibuprofen=K3 ẵibuprofenịị ỵ kỵ off 7ị where koff(2) and koff(3) indicate values of koff occurring at K2 < [ibuprofen] < K3, and at ... K3 < [ibuprofen], respectively, and kỵ is the koff value obtained in the off absence of ibuprofen Data analysis Kinetic and thermodynamic data were analyzed with the matlab program (The Math Works, ... s)1) Ibuprofen binding to tHSAheme-Fe(II)-NO Figure shows the binding isotherm for ibuprofen binding to tHSAheme-Fe(II)-NO Analysis of the dependence of the molar fraction of the ibuprofenbound...
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Human Capital and the Development of Financial Institutions: Evidence from Thailand docx
Ngày tải lên :
06/03/2014, 10:20
... in the education variables, only the direct effects of the years of schooling of the head of the household, the years of schooling of the money manager and the average schooling of the heads of ... Sixty-eight percent of the banks in the Northeast and 81% of the banks in the Central region make loans, while only 35% of the banks in the Northeast and 53% of the banks in the Central region offer savings ... savings and lending services In the Northeast, only 17% of the banks offer savings and lending In the Central region, 40% of the banks offer both savings and lending services In the Northeast, the...
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ROUTLEDGE STUDIES IN SCIENCE, TECHNOLOGY AND SOCIETY: Human-animal relations and the rise of veterinary medicine pot
Ngày tải lên :
06/03/2014, 16:20
... changes in the humananimal relationship and the rise of the veterinary regime from the time of animal domestication and the inception of livestock husbandry up until the present day The book, therefore, ... and then agriculturalists, the balance of power between humans and other animals gradually shifted in favour of humans The balance of power between humans and microparasites, however, is another ... which involved neither the drudgery of tilling the land nor the harvesting of crops While the spread of agrarianism brought the existence of domesticated animals to the attention of the hunting peoples...
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Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating fibrinolysis doc
Ngày tải lên :
07/03/2014, 12:20
... on the basis of their model of human CPU, that the two consecutive I at positions 204 and 205 are exposed to the surface, and because they are quite unique to CPU, might be of importance for the ... demonstrated similar Km values of the native and WT, and the YQ mutant CPU with a synthetic and physiological substrate of CPU There seem to be no major changes in the positioning of the propeptide, as indicated ... instructions Expression of mutant proCPUs in insect cells Determination of the half-life (T1/2) of CPU’s activity The T1 ⁄ of the activity of the best mutants secreted in the supernatant of the cells in...
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Báo cáo khoa học: Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding pptx
Ngày tải lên :
07/03/2014, 15:20
... absence of the intracellular and transmembrane domains does not influence carboxypeptidase activity of GCPII and neither does the attachment of the HisXpress epitope at the N-terminus of the 44/750 ... secretion of the truncated variants into the culture medium, suggesting the importance of the C-terminus for the correct folding and procession of GCPII throughout the secretory pathway These data ... NAAG-hydrolyzing activity (the 44/736 variant), and the C-terminal extension (addition of the V5-His tag in the case of the 44/750_V5-His variant) reduced the activity by a factor of > 104 Furthermore, C-terminal...
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Báo cáo khoa học: The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides pot
Ngày tải lên :
08/03/2014, 10:20
... center of the input target RNA The asterisk indicates the input target RNA; the arrow indicates the digested product bands The amount of digested product obtained is indicated at the bottom of the ... top of the lanes The lanes depicted 0.5 + 0.5 and + are assayed with a mixture of both cell extracts Digested product is detected as a single band on these gels, as the ODN hybridizes to the ... (three of which are shown in Fig 6) had the same low level of antisense inhibition as the parental and vector control cells ( 10% reduction of target mRNA) The high level of activity in vitro, and...
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Hampering the Human Hacker and the Threat of Social Engineering pptx
Ngày tải lên :
08/03/2014, 15:20
... Spoof Detector analyze the phone number of incoming calls to determine if the Caller ID/ANI is spoofed If the number has been spoofed, the call is rejected and never reaches the called party The ... 800 number, the pretexter enters the number to call and the number to display and SpoofApp does the rest • Asterisk Servers – A spare computer, a VoIP service, and free Asterisk software is all ... acquire Among the most popular are: • SpoofCard – Using a SpoofCard, the pretexter merely calls an 800 number provided on the card, enters a PIN, the number for the Caller ID display, and the number...
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Bacteria are often maligned as the causes of human and animal disease (like this one, Leptospira, which causes serious disease in livestock)
Ngày tải lên :
15/03/2014, 13:09
... liver and spleen Fruit bats not show any symptoms Best candidate to be the reservoir More research needs to be done Geography The link between human infection by the Ebola virus and their proximity ... photophobia and hyperlacrimation) - hearing loss - unilateral orchitis( inflammation of one or both of the testes) ** These conditions are usually relieved with the treatment of 1% atropine and steroids ... as the Democratic Republic of Congo In these two instances the mortality rate was between 50 –90% Following those epidemics, Ebola hit Africa in many other instances the worst yet being in the...
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human intent and the aftermath of it
Ngày tải lên :
21/03/2014, 22:04
... dealwith the devil for personal gain In the narrative, Jabez is frustrated with the illness ofhis wife, the condition of his animals, and his unproductive crops Jabez inadvertentlysummons the devil and ... political andspiritual lessons to be learned from "The Devil and Daniel Webster" are those whichare very important to the existence and survival of every human being alive today Both "The Devil and ... "While the selling of one's soul and the inhumaneconsequences of greed are significant, they become subjects for laughter throughIrving's character portrayals and his use of ironic understatement",...
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BELMONT REPORT: ETHICAL PRINCIPLES AND GUIDELINES FOR THE PROTECTION OF HUMAN SUBJECTS OF RESEARCH ppt
Ngày tải lên :
22/03/2014, 15:21
... judgments, including the nature and degree of risk, the condition of the particular population involved, and the nature and level of the anticipated benefits (v) Relevant risks and benefits must ... investigators and members of their institutions are obliged to give forethought to the maximization of benefits and the reduction of risk that might occur from the research investigation In the case of ... the subjects should understand clearly the range of risk, and the voluntary nature of participation A special problem of consent arises, where informing subjects of some pertinent aspect of the...
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