... D: Health-related quality of life during post-induction chemotherapy in children with acutelymphoblasticleukemiain remission: An influence of corticosteroid therapy Int J Oncol 1997, 11(2):333-339 ... is impaired in children during cancer treatment, and the results of this study suggest that impaired sleep might be one of the contributing factors Better counseling and treatmentof sleep problems ... al.: Impaired sleep affects quality of life in children during maintenance treatment for acutelymphoblastic leukemia: an exploratory study Health and Quality of Life Outcomes 2011 9:25 Submit...
... concerning an infectious origin of childhood leukemia ‘Population mixing’ hypothesis by Kinlen In early 1980, an unusual increase in the incidence of childhood leukemia was observed inyoung people ... agent(s) involved in Kinlen model is still not known In fact, most of the population mixing studies had failed to find an increase in a symptomatic infection inadults or children, paralleling the increase ... herpesvirus infections and risk ofacutelymphoblasticleukemiain the offspring American journal of epidemiology 2003;158(3) 207-213 Infectious Etiology of Childhood AcuteLymphoblastic Leukemia, ...
... 24) of chronic neck pain sufferers, including neck pain intensity, neck function, disability and its overall influence on quality of life Methods A randomised, controlled single-blinded preliminary ... greater number of participants to determine the length of the treatment effect in the absence of ongoing treatment Reduction in VAS scores were not observed in participants receiving either the ... neck and upper back of participants ENAR treatment involved setting the device to an intensity determined by the individual participant's tolerance and applying it to the skin in accordance with...
... 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment) ; proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive treatment) ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the ... assist in clinical decision-making [7,8] HRQOL is defined as a multidimensional construct composed of the patients' perceptions of the impact of disease and treatment on his or her functioning in...
... 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment) ; proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive treatment) ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the ... assist in clinical decision-making [7,8] HRQOL is defined as a multidimensional construct composed of the patients' perceptions of the impact of disease and treatment on his or her functioning in...
... (ALL) patients undergoging total body irradiation (TBI) precondionting as human beings in vivo irradiation model The advantage of using this model lies in full view ofin vivo microenvironment, ... plasmid-constructed ß-actin, HVR2 and CD standards were used in each run of real-time PCR Of these, both plasmids containing the CD breakpoint and the HVR2 region were kindly provided by Professor E Kirches ... lymphocytes was determined in a set of independent experiments First, a TaqMan reaction targeting the house keeping gene ß-actin was used to measure the amount of genomic DNA present in cells A second...
... decrease, thus reducing the inhibitory effect of the peripheral signal informing of the accumulation of body stores of energy We cannot explain the presence of particular clusters of leptin receptor ... levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acutelymphoblasticleukemia Journal of ... insulin and leptin receptors are located in key brain areas, such as the hypothalamic arcuate nucleus In some cells of hypothalamus, leptin and insulin activate both JAK-STAT and PI3K signaling...
... expression of the hybrid protein that contains the functional domains of AML-I under the transcriptional control of the TEL promoter may be involved in oncogenic transformation [2,22] In this study ... rearranged in a wide variety of hematological malignancies In particular, TEL is fused to the platelet-derived growth factor receptor β in CMML, to the ABL tyrosine kinase inacute myeloid leukemia ... to determine how to best integrate TEL-AML1 testing into routine patient care Abbreviations ALL: Acutelymphoblastic leukemia; CD: cluster differentiation; CMML: chronic myelomonocytic leukemia; ...
... other four genes of interest in the healthy controls Discussion Increasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11B mRNA expression in most T-ALL cases ... amounts of the genes of interest and the b2M reference gene were measured in two independent assays The 2(-ΔΔCT) method was used to present the data of the genes of interest Huang et al Journal of ... showed that the inhibition of BCL11B expression by siRNA selectively inhibited proliferation and effectively induced apoptosis in human T-cell acutelymphoblasticleukemia (T-ALL) cell lines (Jurkat,...
... variations in drug disposition, rather than reflecting treatment resistance Individualized medicine and childhood acutelymphoblasticleukemia for implementing individualized medicine the following ... and outlined in numerous publications, but in spite of extensive research within almost all areas of medicine, few outcome predictors are implemented in routine clinical decision-making [2] Hence, ... refined by adding monitoring of the early response to induction chemotherapy (i.e monitoring of minimal residual disease) However, due to the high frequency of toxicity, general treatment intensification...
... in the blood in distinct particles containing both lipid and proteins (lipoproteins) Three major classes of lipoproteins are found in the serum of a fasting individual: low density lipoproteins ... Heart Institute Study, INTACT ∆ See List of Studies appendix for listing of the full names of these clinical trials II–4 Results of clinical trials of LDL lowering find support from a review of ... lowering of LDL cholesterol using both public-health and clinical approaches robust findings of a large number of studies, especially those using HMG CoA reductase inhibitors (statins) Clinical...
... miles in 30 minutes Bicycling miles in 30 minutes Raking leaves for 30 minutes Dancing fast (social) for 30 minutes Walking miles in 30 minutes (15 min/mile) Water aerobics for 30 minutes Shoveling ... would include walking a 15-minute mile, weeding and hoeing a garden, carrying a load, cycling, skiing, tennis, and dancing High activity would include jogging a mile in 10 minutes, walking with ... for 15 minutes Swimming laps for 20 minutes Stairwalking for 15 minutes Basketball (playing a game) for 15–20 minutes Jumping rope for 15 minutes Running 11/2 miles in 15 minutes (15 min/mile)...
... found in these adults with persisting symptoms of childhood constipation may be explained by the high frequency of pain complaints, i.e painful defecation and abdominal pain This finding seems in ... clinical outcome resulted in social consequences in one-fifth ofadults with persistence of symptoms Adults still experiencing symptoms of constipation and/or fecal incontinence applied more often ... consequences inadults with unsuccessful clinical outcome In the 43 adults with childhood constipation continuing into adulthood, self-reported complaints were constipation in 76.7% and fecal incontinence...
... version of the 10-item CD-RISC show good psychometric properties and a high level of reliability and validity inyoungadults The findings also confirmed a single dimension underlying the 10 items of ... The final score on the questionnaire was the sum of the responses obtained on each item (range 0-40) and the highest scores indicated the highest level of resilience In order to define the final ... reliability of the Spanish version of the 10-item CD-RISC was similar to that of the original version (Cronbach’s a of the original version = 0.85 and of the Spanish version = 0.85), and the weights in...
... compounds currently in development are heterocyclic compounds containing components that structurally mimic the purine ring of adenosine and become inserted into the ATP-binding site of FLT3 [69] Among ... tyrosine kinase inhibitor Leukemia 2002, 16:2027-2036 72 Tse KF, Novelli E, Civin CI, Bohmer FD, Small D: Inhibition of FLT3mediated transformation by use of a tyrosine kinase inhibitor Leukemia ... H, Roesel J, Giles F, et al: Clinical resistance to the kinase inhibitor PKC412 inacute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain Blood 2006, 107:293-300 93 Piloto...
... the breakpoint to regions downstream of the stop codon of SET and to intron 17/18 of NUP214 in both cell lines AC-3' For the determination of genomic SET and NUP214 breakpoints in cell lines LOUCY ... del(9)(q34.11q34.13) in cell lines LOUCY and MEGAL FISH analysis with BAC clones showed loss of the central (green) signal containing ABL1 and the 5'part of NUP214 in one chromosome homolog in both cell lines ... SET-NUP214 protein expression SET-NUP214 protein expression Western blot analysis with Ab raised against the N-terminal region of SET and against the C-terminal region of NUP214 Cell lines LOUCY and...
... pathological findings of RA joints Discussion To the best of our knowledge, this is the first reported case of co-existing AML-MLD and EBV-associated T-LPD in RA It is possible that the development of AML ... and C: Hematoxylin and eosin (HE) staining and double immunohistochemistry analyses of BM biopsy (B) and skin biopsy (C) B: HE showed the diffuse infiltration of small lymphocytes into BM tissue, ... abnormal karyotype, i(7)(p10), was detected inof 20 cells examined After receiving two courses of low-dose Ara-C (30 mg continuous intravenous drip injection (d.i.v.) for 14 days), the patient...
... reports exist of myelodyplasia rapidly transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that ... regarding the toxicity of TMZ, so questions have been raised about its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in ... The action of TMZ has been shown to be augmented in the concurrent presence of radiation, so the proof of efficacy and superiority of TMZ has led to a paradigm shift in the management of aggressive...
... reports exist of myelodyplasia rapidly transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that ... regarding the toxicity of TMZ, so questions have been raised about its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in ... The action of TMZ has been shown to be augmented in the concurrent presence of radiation, so the proof of efficacy and superiority of TMZ has led to a paradigm shift in the management of aggressive...
... of serum C-reactive protein in the management of infection in the elderly Age Ageing 1986, 15:257-266 35 Mary P, Veinberg F, Couderc R: Acute meningitis, acute phase proteins and procalcitonin ... analysis BT participated in the inclusion and treatmentof patients FR participated in the inclusion and treatmentof patients OM participated in the inclusion and treatmentof patients AC carried ... lactate in 78 cases of adult meningitis Intensive Care Med 1990, 16:196-200 22 Gould IM, Irwin WJ, Wadhwani RR: The use of cerebrospinal fluid lactate determination in the diagnosis of meningitis...