treatment of acute lymphoblastic leukemia in middle age and older adults

báo cáo hóa học: " Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia: an exploratory study" pdf

... During dexamethasone treatment duration of sleep was increased and there was an increase in nighttime awakenings, restless sleep and nap time An association between poor quality of sleep and ... and QoL during ALL treatment has not yet been studied Insight in the relationship between sleep and QoL may help develop interventions in order to improve QoL during and after childhood ALL treatment ... used in pediatric oncology studies [22,32-34] and includes subscales with age- specific questions for determining problems in relevant areas during cancer treatment such as pain, nausea, treatment...

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CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC docx

Danh mục: Sức khỏe giới tính

... identity of the infectious agent(s) involved in Kinlen model is still not known In fact, most of the population mixing studies had failed to find an increase in a symptomatic infection in adults ... herpesvirus infections and risk of acute lymphoblastic leukemia in the offspring American journal of epidemiology 2003;158(3) 207-213 Infectious Etiology of Childhood Acute Lymphoblastic Leukemia, ... people living in the vicinity of nuclear reprocessing plants in Cumbria, England and Dounreay, Scotland It was thought that such increase in leukemias was the result of radio‐ active contamination,...

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báo cáo khoa học: "Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report" docx

Danh mục: Báo cáo khoa học

... Hematoxylin and eosin (HE) staining and immunohistochemistry analyses of bone marrow (BM), spleen, and lymph nodes Hematoxylin and eosin (HE) staining and immunohistochemistry analyses of bone ... finger joints were slightly deformed, and the membranes of these joints showed mild synovial and lymphoid proliferation These findings were compatible with the pathological findings of RA joints ... hypoplastic, with increased myeloid blasts The erythroid series showed dysplastic changes (Wright-May-Giemsa staining; original magnification: ×800) B and C: Hematoxylin and eosin (HE) staining and double...

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Báo cáo hóa học: " The incidence of acute encephalitis syndrome in Western industrialised and tropical countries" pdf

Danh mục: Hóa học - Dầu khí

... vaccine against these viruses was introduced This was also noted by other researchers in Finland [8] In a small prospective study of central nervous system (CNS) infections in Helsinki, Finland in ... the leading cause of acute encephalitis until effective vaccination programmes virtually eliminated it from Finland [8] Patients aged 16 or over admitted to one main hospital in Finland between ... under year of age (annual incidence 16.7 per 100,000); the incidence remained quite high until 10 years of age, and then gradually declined for children up to the age of 15 years (annual incidence...

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báo cáo hóa học:" Fitness and Health-Related Quality of Life Dimensions in Community-Dwelling Middle Aged and Older Adults" docx

Danh mục: Hóa học - Dầu khí

... more related to perceive problems in each dimension of HRQoL in a large sample of community-dwelling middleaged and elderly population including a high percentage of participants who did not have ... warm-up exercises involving of low intensity walking and stretching exercises of the lower and upper-body The following fitness outcomes were then measured: Upper body strength Bi-handgrip strength ... minimize the effects of fatigue, the tests were administered in the following order: functional reach, chair sit -and- reach, TUG, handgrip, and back scratch After a 5-min break, the 6-min walking...

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báo cáo hóa học: " Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" potx

Danh mục: Hóa học - Dầu khí

... 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment) ; proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive treatment) ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the ... limited [18-21] The aims of this study were to assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics...

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báo cáo hóa học:" Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" docx

Danh mục: Hóa học - Dầu khí

... 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment) ; proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive treatment) ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the ... limited [18-21] The aims of this study were to assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics...

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Báo cáo khoa học: "Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy" ppt

Danh mục: Báo cáo khoa học

... China Dose-dependent plasmid-constructed ß-actin, HVR2 and CD standards were used in each run of real-time PCR Of these, both plasmids containing the CD breakpoint and the HVR2 region were kindly ... patients undergoging total body irradiation (TBI) precondionting as human beings in vivo irradiation model The advantage of using this model lies in full view of in vivo microenvironment, and without ... to detect single molecule of CD and high linearity was found (y = 3E-12e-0.6358x) in the range of standard samples CD levels in most of the samples were detected between Ct 35 and 39 In all samples...

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báo cáo khoa học: " Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia" docx

Danh mục: Báo cáo khoa học

... levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia Journal of ... determine the polymorphisms of leptin and leptin receptor genes and plasma levels of leptin and leptin soluble receptors in survivors of childhood ALL The study assessed the influence of chemo- and ... insulin and leptin receptors are located in key brain areas, such as the hypothalamic arcuate nucleus In some cells of hypothalamus, leptin and insulin activate both JAK-STAT and PI3K signaling...

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báo cáo khoa học: "Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study" doc

Danh mục: Báo cáo khoa học

... receptor β in CMML, to the ABL tyrosine kinase in acute myeloid leukemia and ALL, and to the product of the MNI gene in myeloproliferative disorders AML-I is the DNA-binding subunit of the transcription ... chromosome in the metaphase and on the interphase nuclei of leukemic cells It was measured in newly diagnosed cases (Table 1) and it was positive in 30/80 (37.5%) determining its frequency in B-lineage ... the frequency of TEL-AML1 fusion in B-Lineage CD10 positive ALL was 37.5% versus 30% in a previous study included multicentres and larger number of patients.23 In our data (22% )of patients with...

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báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc

Danh mục: Báo cáo khoa học

... performed in a 25-μL total volume containing μL of cDNA, μL of 2.5× SYBR Green mix (Tiangen, Beijing, PR China), and 10 μmol/L primer pairs The following cycling conditions were used: initial denaturation ... gene and the other four genes of interest in the healthy controls Discussion Increasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11B mRNA expression in ... NA: Biology and treatment of childhood T-lineage acute lymphoblastic leukemia Blood 1998, 91:735-746 Morris JC, Waldmann TA, Janik JE: Receptor-Directed Therapy of T-Cell Leukemias and Lymphomas...

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Báo cáo y học: " Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia" ppt

Danh mục: Báo cáo khoa học

... emphasized and outlined in numerous publications, but in spite of extensive research within almost all areas of medicine, few outcome predictors are implemented in routine clinical decision-making [2] ... clinical endpoints are chance findings due to combinatorial multiple testing Thus, in individualized medicine candidate associations limited to certain patient subgroup/marker/outcome combinations ... 2The Faculty of Medicine, Institute of Gynecology, Obstetrics and Pediatrics, University of Copenhagen, Denmark Page 10 of 12 Nersting et al Clinical Proteomics 2011, 8:8 http://www.clinicalproteomicsjournal.com/content/8/1/8...

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báo cáo hóa học:" High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia" pot

Danh mục: Hóa học - Dầu khí

... silver stained gel image of the master gel image 2-D pattern of the silver stained gel image of the master gel image 2-D pattern of the silver stained gel image of a master gel image containing the ... formation and maintenance of the histo-architecture Plasmonogen activator inhibitor-2 (PAI-2) Involved in the regulation and inhibition of binding between urokinase-type plasminogen activator and its ... protein for phosphoserin motifs Regulated the interactions and subcellular localization of signalling molecules γ-Catenin Forms a complex with α- and β-Catenin to Cadherins, that are involved in...

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Báo cáo y học: "Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications" pps

Danh mục: Báo cáo khoa học

... compounds currently in development are heterocyclic compounds containing components that structurally mimic the purine ring of adenosine and become inserted into the ATP-binding site of FLT3 [69] Among ... tyrosine kinase domain point mutations that interfere with drug binding is a well-documented phenomenon in CML patients receiving therapy with imatinib [89] Preclinical studies using AML cell lines ... effects of ATO and MEK inhibition, as well as ATO and FLT3 inhibition, on FLT3-ITD cells [101] The combination of ATO and AG1296, an FLT3 inhibitor, profoundly inhibited the growth and induced...

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báo cáo khoa học: "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines" ppsx

Danh mục: Báo cáo khoa học

... breakpoint to regions downstream of the stop codon of SET and to intron 17/18 of NUP214 in both cell lines AC-3' For the determination of genomic SET and NUP214 breakpoints in cell lines LOUCY and ... del(9)(q34.11q34.13) in cell lines LOUCY and MEGAL FISH analysis with BAC clones showed loss of the central (green) signal containing ABL1 and the 5'part of NUP214 in one chromosome homolog in both cell lines ... SET-NUP214 protein expression SET-NUP214 protein expression Western blot analysis with Ab raised against the N-terminal region of SET and against the C-terminal region of NUP214 Cell lines LOUCY and MEGAL...

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báo cáo khoa học: "Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia" pot

Danh mục: Báo cáo khoa học

... products; Lane ALL and Post-CT, BCR/ABL negative Discussion Isolated instances of Ph-negative acute leukemia or high-risk MDS have been observed in the course of interferon-a [4,9] and imatinib therapy ... different disease stages As expected, there are marked difference in the expressional number of TCR Va/Vb between the disease stage of CP and that of Ph-negative ALL Only of all 29 Va and of all 24 Vb ... Guangzhou, 510632, PR China 2Institute of Hematology, Medical College, Jinan University, Guangzhou, 510632, PR China 3Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University,...

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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report." doc

Danh mục: Báo cáo khoa học

... regarding the toxicity of TMZ, so questions have been raised about its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in ... case report and accompanying images A copy of the written consent is available for review by the Editor -in- Chief of this journal Conflict of Interest Both authors declare no conflict of interest ... to be a random finding, the association between TMZ and treatment- related leukemia deserves further study Consent Written informed consent was obtained from the patient for publication of this...

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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report" potx

Danh mục: Báo cáo khoa học

... regarding the toxicity of TMZ, so questions have been raised about its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in ... case report and accompanying images A copy of the written consent is available for review by the Editor -in- Chief of this journal Conflict of Interest Both authors declare no conflict of interest ... to be a random finding, the association between TMZ and treatment- related leukemia deserves further study Consent Written informed consent was obtained from the patient for publication of this...

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Báo cáo khoa học: "Decrease in serum procalcitonin levels over time during treatment of acute bacterial meningitis" ppsx

Danh mục: Báo cáo khoa học

... of serum C-reactive protein in the management of infection in the elderly Age Ageing 1986, 15:257-266 35 Mary P, Veinberg F, Couderc R: Acute meningitis, acute phase proteins and procalcitonin ... analysis BT participated in the inclusion and treatment of patients FR participated in the inclusion and treatment of patients OM participated in the inclusion and treatment of patients AC carried ... management of suspected bacterial meningitis and meningococcal septicaemia in adults J Infect 2003, 46:75-77 19 Bland RD, Lister RC, Ries JP: Cerebrospinal fluid lactic acid level and pH in meningitis...

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Báo cáo y học: "Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema – a systematic review and meta-analysis" docx

Danh mục: Báo cáo khoa học

... applied Duration of non-invasive ventilation and the type of ventilator may have also influenced outcomes, and this was not examined in this review Some different kinds of interfaces and ventilatory ... using higher levels of pressure support ventilation Materials and methods Study design A systematic review and meta-analysis of RCTs focusing on the effect of CPAP and NPPV in the treatment of ... any mention of blinding Standardization of co-interventions: Yes: if there was an attempt to standardize treatment and care besides the assigned interventions No: if no attempt to standardize was...

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