treatment of acute hae attacks see table 1 2010 xii 21
Báo cáo y học: "Adrenal suppression: A practical guide to the screening and management of this under-recognized complication of inhaled corticosteroid therapy" pptx
... (h) Systemic clearance (L/h) 13 2.7* 15 0 /12 0* 20/40* 50-60 2.5 12 2.0 84 Ciclesonide
- 12
- 774
- 0
Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
... 2003 by RAND 17 00 Main Street, P.O Box 213 8, Santa Monica, CA 90407- 213 8 12 00 South Hayes Street, Arlington, VA 22202-5050 2 01 North Craig Street, Suite 202, Pittsburgh, PA 15 213 -15 16 RAND URL: ... of drugs and vaccines for military use, especially for CBW defense; FDA officials whose responsibilities have been reordered by the events of September 11 , 20 01; officials in the Department of ... Drug Application ORA Office of Regulatory Affairs ORO Office of Regional Operations OSD Office of the Secretary of Defense PB pyridostigmine bromide PEO Program Executive Officer PHSA Public Health...
- 99
- 600
- 0
báo cáo khoa học: " Bioethical differences between drug addiction treatment professionals inside and outside the Russian Federation Vladimir D Mendelevich" pdf
... problems? 61. 0%* 27.6% 11 .4% 76 .1% 13 .0% 10 .9% Is Homosexuality, from your point of view, an illness that requires treatment, or not an illness? 21. 1% 62.2% 16 .7% 13 .0% 76 .1% 10 .9% What is your attitude ... that they have no competing interests Received: 12 March 2 011 Accepted: 10 June 2 011 Published: 10 June 2 011 References Elovich R, Drucker E: “On drug treatment and social control: Russian narcology’s ... Principles of Biomedical Ethics edition N.Y., Oxford: Oxford univ Press; 19 89 31 Francoeur RT: Biomedical Ethics: A Guide to Decision Making New York: Wiley; 19 83 doi :10 .11 86 /14 77-7 517 -8 -15 Cite...
- 7
- 230
- 0
A study of quality and safety of herbal medicine adulteration and herb drug interactions
... activities 11 3 11 5 4 .1 Introduction 11 5 4.2 Objective 12 1 4.3 Materials and Methods 12 1 4.3 .1 Chemicals and reagents 12 1 4.3.2 Preparation of L chuanxiong extract 12 2 4.3.3 Animal treatments 12 2 4.3.4 ... medicines 1. 1.2 .1 Chemical identification 1. 1.2.2 Molecular-based methods 1. 2 Safety issues of Herbal Medicines 11 13 1. 2 .1 Introduction 13 1. 2.2 Herb-drug interactions 14 1. 2.3 The mechanisms of herb-drug ... interactions 15 1. 2.3 .1 Pharmacokinetic interactions 16 1. 2.3.2 Pharmacodynamic interactions 1. 2.4 Approaches employed in the studies of herb-drug interactiona 20 21 1.2.4 .1 Introduction 21 1.2.4.2...
- 246
- 273
- 0
Pharmacokinetic and pharmacodynamic mechanisms for reduced toxicity of CPT 11 by thalidomide and st johns wort
... 1. 1 CANCER CHEMOTHERAPY 1. 2 IRINOTECAN (CPT -11 ) 1. 2 .1 1.2.2 Pharmacokinetics of CPT -11 1. 2.3 1. 3 Anti-tumor activity and mechanism of action of CPT -11 5 Toxicities of CPT -11 ... valproic acid) [15 1] (Table 1- 1) 17 Table 1- 1 Experimental therapies and possible modes of action for CPT -11 induced diarrhea Diarrhea Type Experimental Therapy Possible Modes of Action References ... absorption of fluids and electrolytes Adsorbtion of SN-38 & CPT -11 in intestine • • • Promoting epithelial growth Protection of intestinal epithelium Anti-diarrhea effect [15 1, 15 7 -16 2] [11 8, 16 3 -17 0]...
- 221
- 589
- 0
In vivo aspects of potential stereospecific drug interactions of oral warfarin and rutin in rats
... Rat 13 .85±4.33 (10 ) 7.26 1. 82 (10 ) 11 .56±3.73 (10 ) 13 2 22.4 a (11 ) - - 13 3 23.6±4.6 (10 ) 17 .5±2.2 (10 ) - 10 8 - - 7.07 a (13 ) 13 4 - - 10 .4 a (2) 59 19 .5±3.4 (10 ) 11 .9±3.9 (10 ) - 10 4 33 12 .65 (10 ) 58 15 . 81( 10) ... PHARMACOKINETICS 1. 1.4 .1 ABSORPTION 1. 1.4.2 DISTRIBUTION 1. 1.4.3 METABOLISM AND EXCRETION 11 1. 1.5 MEASUREMENT OF ANTICOAGULATION 17 1. 1.6 CHEMICAL ANALYSIS 19 iv 1. 1.7 WARFARIN DRUG INTERACTIONS 1. 1.7 .1 WARFARIN ... 58 15 . 81( 10) 42±6.32 (10 ) 30.5 13 .96(6) 41. 2±4 .16 (6) 36.2 19 .2(6) 13 5 33 14 .6(6) 43.4±8.4(6) - 10 5 37±35 (12 ) 53 14 (12 ) - 13 6 27.5±7.38(6) 36.8 14 .23(6) - 13 7 36 13 (6) 46±7(6) - 13 8 - - 36.3±3.5 (12 ) 13 9...
- 134
- 407
- 0
Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients
... 500 mg (12 mo) 24 1g 1g 10 1g 33 g (1wk) 2 .1 1. 5 1. 2±0.8 16 .2 11 .8 45 11 .8 [47] CsA/Steroids 1. 4 1 2 .1 1. 2 12 ±5.7 49.8±24.8 [48] TAC/Steroids 0.78 a (0.33 -12 ) 1. 5 a (0 .1- 5.0) 2.2 a (0.2- 71) 2.4 ... 0.9±0.6 a (0.5-3) 2.5 a (1. 5-8) 1. 4±0.6 1. 8±0.7 11 .9±2.5 14 .9 1. 9 14 .1 11 .7 16 .2 12 .5 35.7±3.2 37.5±2.7 41. 7 13 .2 42.9 17 .9 1. 7 25.5 61. 4 1. 7 33.4 74.7 1. 5 c 11 .7 c 44.9 b 3.8 c 12 .8 c 30.5 b CsA/Steroids ... 3.9 1. 2 16 3±25 215 ±26 2095±259 [45] CsA/Steroids 3.3±0.8 13 7± 21 193±22 19 01 212 TAC/Steroids 2.0 a (0.8 -12 ) 84 a (14 -428) 53 a (3 -13 6) 56 a (20-92) 44 a (13 -15 7) 11 9 a (45- 516 ) 11 53 a (333- 612 3)...
- 207
- 246
- 0
Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... Nephrosclerosis Nephronophthisis 14 1 1 15 (11 - 31) 13 (11 -17 ) 16 (12 -23) 13 (17 - 21) 18 (15 -23) 17 (14 - 21) 18 (16 -22) 27 (17 -59) 24 (16 -34) 20 (14 -29) 16 (13 -22) 18 (12 -24) 17 (11 -25) 19 (15 -23) Pharmacogenetics ... 1. 6 (1. 2-2 .1) 1. 6 (1. 3-2 .1) 1. 4 (1. 2-2) 1. 4 (1. 1 -1. 7) 1. 3 (1. 1 -1. 6) 11 (8 .1- 12.3) 10 .7 (9.2 -13 ) 10 .4 (9.2 -12 .1) 10 (8.5 -11 .2) 9 .1 (7.5 -10 .9) 7.2 (6 .1- 8.7) 6.7 (5.2-7.9) 38/23-50 Discussion Demographic ... 41/ 35-54 42/37-53 41/ 35-54 28 /12 36/4 34 38/24-50 36/29-49 14 days month months months 12 months 24 months 36 months 1. 7 (1. 3-2.7) 1. 8 (1. 3-2.3) 1. 6 (1. 2-2 .1) 1. 6 (1. 3-2 .1) 1. 4 (1. 2-2) 1. 4 (1. 1 -1. 7)...
- 7
- 785
- 0
Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... cost-effectiveness Conflict of interest Erwin Sablon and Fred Shapiro both work for Innogenetics NV References 10 11 12 13 Lok ASF, McMahon BJ Chronic hepatitis B Hepatology 20 01; 34 :12 25 -12 41 Bowden S Laboratory ... Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy Hepatology 19 98;27 :17 11- 1 716 32 Cane PA, Cook ... effect [9 ,10 ] is termed breakthrough infection It is now known that genotypic resistance to lamivudine emerges in approximately one quarter of patients after one year of treatment [11 13], rising...
- 9
- 590
- 0
U.S. Food and Drug Administration - Juice HACCP — The Final Rule
... June 27, 19 90, and July 10 and 18 , 19 90 FDA, Health hazard evaluation, classiÞcation, and FDA Enforcement Report for Þrm-initiated recall #F-400/4 21 1, May 23, 19 91, and June and 19 , 19 91a FDA, ... were natamycin (FDA, 19 91a–c), sulÞtes (FDA, 19 95a–c), FD&C yellow No (FDA, 19 88a,b, 19 89, 19 90, 19 92a–c, 19 93a,b), and salt (FDA, 19 95a–c) Five recalls between 19 91 and 19 97 were caused by improper ... having no tolerance (FDA, 19 95a–c) None of the 12 2 samples of apple juice or 44 samples of other fruit juices were violative Out of 17 95 samples of domestic vegetables and vegetable products tested,...
- 32
- 583
- 1
Tài liệu NEW INSIGHTS INTO TOXICITY AND DRUG TESTING pptx
... Gut 19 91; 32 (11 ): 13 81- 1385 [ 21] Bulsterli UA Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity Toxicology and Applied Pharmacology 2003; 19 2(3): 307-322 DOI: 10 .10 16/ ... Toxins 19 95;3 :11 9 -12 8 [18 ] McDermott CM, Nho CW, Howard W, Holtons B The cyanobacterial toxin, Microcys‐ tin-LR, can induce apoptosis in a variety of cell types Toxicon 19 98;36 (12 ) :19 81- 1996 [19 ] ... Effects of troglitazone on HepG2 viability and mitochondrial function Toxicological Sciences 2002; 69 (1) : 13 1 -13 8 DOI: 10 .10 93/toxsci/69 .1. 1 31 [46] O’Brien PJ, Irwin W, Diaz D, Howard-Cofield...
- 252
- 398
- 0
Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf
... (0.3) 2.2 (1. 8) 1. 2 (1. 0) 2.2 (1. 8) 0.09 (0.08) 0.2 (0.2) 1. 2 (1. 0) 0.7 (0.6) 0.4 (0.3) 11 .0 (9.2) 1. 2 (1. 0) 1. 2 (1. 0) < 0.07 (< 0. 01) 0.8 (0.7) 1. 2 (1. 0) 0.8 (0.7) 0.4 (0.3) 8.3 (6.9) 2 .1 (1. 0) 0.6 ... sequence into the S1¢ binding site of HIV -1 PR Space filling models of the P1¢ residue of peptides 7, 10 , 11 and 14 (Table 4) are shown occupying the S1¢ binding site of wild-type HIV -1 PR suggest that ... (3.0) 0.7 (1. 0) 1. 1 (0.9) 1. 6 0.4 3.2 5.9 2.8 7.9 2.5 1. 0 4.2 9.6 4 .1 45.4 (1. 0) (0.4) (1. 7) (2.6) (0.8) (20 .1) (1. 0) (0.8) (2.0) (8.0) (2.3) (39.0) (1. 0) (0.5) (0.8) (4.3) (1. 0) (2.0) (1. 0) (0.3)...
- 7
- 480
- 0
Báo cáo khoa học: Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1 pot
... 37 15 22 11 66 54 16 4 84 51 2 21 21 51 111 29 20 27 22 18 13 – – – 13 ± 21 ± – – 32 ± 12 9 ± – – – ND ND – – 25 ± 8±3 ± ± ± ± ± ± ± ± ± 14 14 30 10 ± ± ± ± ± ± ± ± ± 12 6 10 18 6 TMDs and NBDs, ... adopted (Table 2) 3978 ± ± ± ± ± ± ± ± ± 14 50 24 63 35 ± ± ± ± ± ± ± ± ± 18 17 12 10 10 24 Conformational changes – amino region of TM12 As shown in Table 2, the amino region of TM12 (L976C–V982C) ... Pharmacol 60, 254–2 61 20 Krupka RM (19 93) Coupling mechanisms in ATP-driven pumps Biochim Biophys Acta 11 83, 11 4 12 2 21 Druley TE, Stein WD & Roninson IB (20 01) Analysis of MDR1 P-glycoprotein conformational...
- 12
- 380
- 0
Báo cáo khoa học: Typical 2-Cys peroxiredoxins – modulation by covalent transformations and noncovalent interactions doc
... rates (c 10 7 m )1 s )1) comparable with those of catalases (c 10 7 m )1 s )1) and glutathione peroxidases (c 10 8 m )1 s )1) [22,44,45] The precise measurement of the kinetic constants of Salmonella typhimurium ... Med 45, 482–493 14 Copley SD, Novak WR & Babbitt PC (2004) Divergence of function in the thioredoxin fold suprafamily: 15 16 17 18 19 20 21 22 23 24 25 26 evidence for evolution of peroxiredoxins ... 20346–20354 10 Dietz KJ, Horling F, Konig J & Baier M (2002) The function of the chloroplast 2-cysteine peroxiredoxin in peroxide detoxification and its regulation J Exp Bot 53, 13 21 13 29 11 Trivelli...
- 16
- 396
- 0
Báo cáo khoa học: C-terminal, endoplasmic reticulum-lumenal domain of prosurfactant protein C – structural features and membrane interactions ppt
... assigned (e.g 12 M 51+ ) are indicated nd 0.5 0.5 0.5 nd 59 0.5 80 13 0 18 0 70 11 500 90 10 0 240 11 500 11 0 11 25 15 0 12 0 12 0 17 0 19 7 Fig Limited proteolysis of CTC The amino acid sequence of human CTC ... interactions 6M32+ 3M16+ 10 0 6M30+ 3M15+ 6M29+ 12 M57+ 8M38+ 6M28+ 3M14+ % 12 M 51+ 6M34+ 3M17+ 6M39+ 2M13+ 6M35+ 6M36+ 3M18+ 3M 21+ 6M38+ 20+ 19 + 3M22+ 3M 3M 6M27+6M26+ 3M13+ 6M 31+ 6M33+ 9M36+ 6M24+ ... residues 82 12 5, 14 1 15 3, and 16 8– 19 7, whereas the [M + H]+ ion at 9400.4 corresponds to peptides 82 12 5, 14 0 15 3, and 16 8 19 7 (supplementary Fig S1B; see Fig for the amino acid sequence of CTC)...
- 12
- 310
- 0
Báo cáo khoa học: Identification, subcellular localization and functional interactions of PilMNOWQ and PilA4 involved in transformation competency and pilus biogenesis in the thermophilic bacterium Thermus thermophilus HB27 ppt
... Microbiol 16 8, 16 9 17 5 17 Virji M (19 97) Post-translational modifications of meningococcal pili Identification of common substituents: glycans and alpha-glycerophosphate Gene 19 2, 14 1 14 7 18 Porstendorfer ... specificity of the N-terminal domain Mol Gen Genet 243, 11 2 11 8 10 Bitter W (2003) Secretins of Pseudomonas aeruginosa: large holes in the outer membrane Arch Microbiol 17 9, 307– 314 11 Collins ... Jr & Weber P (19 81) Deglycosylation of glycoproteins by trifluoromethanesulfonic acid Anal Biochem 11 8, 13 1– 13 7 40 Hayat MA (19 89) Negative staining In Principles and Techniques of Electron Microscopy...
- 12
- 702
- 0
Cadmium and zinc interactions and their transfer in
... 0.04 0 .11 " 0.07 0.50" 0.27 31. 08" 7.38 33. 31" 6.70 33.94" 10 .11 11 11 11 0.05" 0.03 0.26" 0 .11 0.44" 0.20 15 . 71" 3.66 21. 28" 7.66 61. 40" 18 .24 Grain Stem Root 13 13 13 0. 61" 0. 41 1. 91" 1. 32 6.92" ... 0 .19 WA 0.06 0 .18 1. 01 0.86 0.67 1: 1.4:4.4 1: 2 :10 1: 3 :11 0.43 0 .19 0 .18 0.60 0. 21 0.35 0.60 0. 21 0.98 1: 1.4 :1. 4 1: 1 :1 1:2:5.4 Corn Ž Zea mays L YA 0.23 MA 0 .10 WA 0.06 0.95 0.88 0.83 1: 3:4 1: 5:9 ... Root 16 16 16 0.05" 0.03 0.07" 0.02 0.23" 0 .16 25.38" 6.27 35.69" 5.44 35.56" 8.42 13 13 13 0.05" 0.03 0 .16 " 0.07 0. 21" 0 .11 16 .02" 3.74 18 .35" 3.77 43. 71" 10 .83 MA Grain Stem Root 18 18 18 0.05"...
- 9
- 502
- 0
Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc
... D1D2SD3 D1D2D3S D1SD2D3S D1D2SD3S D1SD2SD3 D1SD2SD3S 15 1 17 8 10 9 16 3 13 8 13 7 17 3 54 10 0 12 3 96 10 4 90 11 2 12 3 52 3 .1 2.9 2 .1 2.5 3.0 1. 6 2.5 3.0 2.2 2 .1 1.9 1. 6 2.0 1. 4 1. 7 2.9 1. 4 1. 4 1. 1 1. 6 ... (lmolÆmin )1 mgÆprotein )1) kcat (s )1) kcat ⁄ KM(PCr) (s )1 mM )1) Wild-type D1SD2D3 D1D2SD3 D1D2D3S D1SD2D3S D1D2SD3S D1SD2SD3 D1SD2SD3S 328 270 18 0 19 6 75 12 5 11 3 0.7 715 586 392 427 16 4 273 243 1. 6 ... 392 427 16 4 273 243 1. 6 330 280 210 270 80 200 14 0 0.6 ± ± ± ± ± ± ± ± 16 .0 9.1ab 5.1a 14 .0a 1. 1ab 7.6a 11 .6a 0.1a ± ± ± ± ± ± ± ± 34.9 19 .8ab 11 .1a 30.4a 2.4ab 16 .5a 24.9a 0.2a a Values that...
- 9
- 567
- 0
Báo cáo khoa học: Adventitious reactions of alkene monooxygenase reveal common reaction pathways and component interactions among bacterial hydrocarbon oxygenases ppt
... sp strain JS150 Appl Environ Microbiol 61, 3336–3346 11 Lipscomb JD (19 94) Biochemistry of the soluble methane monooxygenase Annu Rev Microbiol 48, 3 71 399 12 Small FJ & Ensign SA (19 97) Alkene ... reactions J Biol Chem 267, 17 588 17 597 31 Lee S-K, Nesheim JC & Lipscomb JD (19 93) Transient intermediates of the methane monooxygenase catalytic cycle J Biol Chem 268, 215 69– 215 77 32 Liu KE, Valentine ... hydroxylase of sMMO from Methylococcus capsulatus (Bath) by hydrogen peroxide Biochim Biophys Acta 11 63, 10 5 11 2 FEBS Journal 272 (2005) 26 61 2669 ª 2005 FEBS Adventitious reactions of alkene monooxygenase...
- 9
- 300
- 0
Radiological Findings of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-AIDS Adults: Comparisons with Findings of Multidrug-Resistant and Drug-Sensitive Tuberculosis docx
... 0-4) 1. 38 5.99 (0, 0.50, 0-50) 2.33 1. 71 (2, 0.26, 0-6) 2.88 1. 70 (3, 0.26, 0-6) 1. 19 1. 13 (1, 0 .18 , 0-5) 1. 17 1. 03 (1, 0 .16 , 0-3) 0. 21 0.57 (0, 0.09, 0-3) 0.67 0.72 (1, 0 .11 , 0-3) 2.45 4.87 (1, ... 0-5) 1. 58 1. 54 (1, 0. 21, 0-6) 1. 55 1. 42 (1, 0.20, 0-6) 0.43 0.69 (0, 0 .10 , 0-3) 1. 08 0.98 (1, 0 .13 , 0-3) 0.36 0.83 (0, 0 .12 , 0-4) 0.68 0.96 (0, 0 .13 , 0-4) 1. 47 1. 13 (2, 0.29, 0-3) 1. 53 1. 13 (2, ... 13 1 (93) 12 4 (88) 0 71 (50) 0 91 (65) 035 (25) 026 (18 ) 0 51 (36) 0 21 (15 ) 036 (26) 016 (11 ) 06 (4) 046 (33) 37 (88) 41 (98) 40 (95) 30 ( 71) 30 ( 71) 07 (17 ) 23 (55) 29 (69) 17 (40) 10 (24) 04 (10 )...
- 10
- 460
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ