transforming growth factorβ1 induced epithelialmesenchymal transition in hepatic fibrosis
Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... that in intact G1cells (subdiploid cells).For annexin-V/PI staining 1 ì 106 cells were resuspended in 50 àl binding buffer (Roche Diagnostics, Lewes, UK) and incu-bated with annexin-V/FITC ... physiologicalTGF-β1 activation during blood clotting in patients and controlindividuals, and examined whether TGF-β1 activation wasassociated with clinical phenotype, in particular inflammatorydisease ... [19,20] involving protease (plasmin) activation andinteraction of TGF-β1 with thrombospondin-1. Using an ELISAassay validated for detection of active TGF-β1 [15,16], wedetermined the increased...
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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx
... eitheractivate or inhibit protein synthesis and cell growth [2].The most well defined signaling mechanism regulatingmTOR activity in skeletal muscle is the insulin like growth factor-1 (IGF-1) ⁄ insulin-dependent ... rapa-mycin (mTOR) plays a critical role in regulating therate of protein synthesis and cell hypertrophy in skele-tal muscle [3–6]. mTOR is a serine ⁄ threonine kinase ofthe phosphatidylinositol kinase-related ... signal-regulated kinase; GAP, GTPase activating protein; GST, glutathione S-transferase; IGF-1, insulin like growth factor-1;MEK, mitogen-activated protein kinase kinase; mTOR, mammalian target of rapamycin;...
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Báo cáo y học: "Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes" docx
... of several signaling pathways in transforming growth factor-beta-1 (TGF-β1) -induced expression of the Ank gene. (a) Kinetics of sign-aling events induced by TGF-β1. Total proteins were extracted ... 1Effect of transforming growth factor-beta-1 (TGF-β1) on proteins regu-lating inorganic pyrophosphate metabolismEffect of transforming growth factor-beta-1 (TGF-β1) on proteins regu-lating inorganic ... signal-regulated kinase; MEK-1, mitogen-activated protein kinase/extracellu-lar signal-regulated kinase kinase 1; p38-MAPK, p38-mitogen-activated protein kinase; PKA, protein kinase A; PKC, protein kinase...
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Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
... thecytokines involved in the induction of FXR1 remain un-characterized. The regulation by the anti -in ammatorycytokine transforming growth factor-b1 (TGF-b1) ofthe proinflammatory cytokine TNF-a ... example, in the stabilization ofchemokine mRNA. TGF-b1 opposes LPS -induced chemokine stabilization by inhibiting p38 MAPK [33].To determine whether this signalling pathway wasinvolved in FXR1 induction, ... demonstrated that FXR1, an mRNA-binding protein, plays an essential role in this process.Building on previous work showing that TGF-b1 caninhibit LPS -induced TNF-a and chemokine production[33,35],...
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báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot
... Clinical Pharmacology, Naples, ItalyEmail: Giovanni Tarantino* - tarantin@unina.it; Paolo Conca - paolo.conca@unina.it; Antonio Riccio - riccio@unina.it; Marianna Tarantino - tarantin@unina.it; ... Serum concentrations of transforming growth factor-beta1 and ferritin.Results: High concentrations of transforming growth factor-beta1 were noticed in patients suffering from both fatty liverand ... its use in clinical settings [1].The definition of "benignity" concerning FL is wide-accepted [2] but conceptually difficult to maintainbecause the mechanisms, i.e., insulin resistance...
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Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf
... doxorubicin andvincristine against Ewing’s sarcoma cells. Clin Cancer Res 2001, 7:1790-7.30. Martins AS, Mackintosh C, Martín DH, Campos M, Hernández T, Ordóñez JL,de Alava E: Insulin-like growth ... pathway inhibition byADW742, alone or in combination with imatinib, doxorubicin, orvincristine, is a novel therapeutic approach in Ewing tumor. Clin CancerRes 2006, 12:3532-40.31. Kim WY, Jin ... on IGF1R in GISTs anddiscuss the future perspectives in this promising field.IntroductionRecent years have seen a growing interest in insulin-like growth fa ctor 1 receptor (IGF1R) in medical...
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
... reduction in inflammation in arthriticjoints, TGF-β1 expression induced fibrogenesis andmuscle edema. In addition, TGF-β1 expression in the ade-novirally infected synovial lining also resulted in inductionof ... toconfer sustained, intra-articular TGF-β1 expression in bothnaïve and arthritic rabbit knee joints. Intra-articular injec-tion of adenoviral vector expressing human transforming growth factor ... antigen -induced arthritis (AIA), rabbitswere sensitized to ovalbumin by intradermal injections of 5mg ovalbumin emulsified in Freund’s complete adjuvant.Arthritis was initiated in both hind knees...
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Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc
... Mohan S,Ljunghall S: Circulating levels of insulin-like growth factor-Iand -II, and IGF- binding protein-3 in inflammation and afterparathyroid hormone infusion. Bone Miner 1994, 24:25-31.33. ... Poli V,Martini A, Ciliberto G, Fattori E: Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in childrenwith ... significantly during thefirst year in the HRT group compared with the controls.There is a need to be cautious in interpreting this finding,since there were significantly more missing OPG samples in the...
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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
... 39:968-978.26. Morales TI: The insulin-like growth factor binding proteins in uncultured human cartilage. Increases in insulin-like growth factor binding protein 3 during osteoarthritis. Arthritis ... Holly JMP: Changes in the local regulation of insulin-like growth factors I and II andinsulin-like growth factor-binding proteins in osteoarthritis ofthe canine stifle joint secondary to cruciate ... McCarthy JR, Xie Q, Ling N, Chen C: Quino-line-carboxylic acids are potent inhibitors that inhibit the bind-ing of insulin-like growth factor (IGF) to IGF-binding proteins.Bioorg Med Chem...
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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx
... effector cells is underscored both in experimental models and in humans in which the numbersReview Transforming growth factor-ββ -induced regulatory T cells refereeinflammatory and autoimmune diseasesSharon ... Beyondengaging Smad activity, TGF-β triggers the extracellularsignal-related kinase and p38 mitogen-activated kinasepathways [44] to link additional signaling cascadesinvolved in modulating cell ... [64,65]. Moreover, in adramatic turnaround of allergen -induced asthmatic lungdisease, TGF-β-converted /induced Treg, when transferredto an asthmatic mouse, suppressed allergen -induced inflammation...
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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
... of various transforming growth factor (TGF)-beta signaling molecules in cartilageStaining of various transforming growth factor (TGF)-beta signaling molecules in cartilage. Paraffin sections ... WangW, Dunander C, Heingard D: Inhibition of interleukin-1alpha- induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibi-tors: potential ... Boumediene K: Mediation of interleukin-1beta- induced transforming growth factor beta1 expression by acti-vator protein 4 transcription factor in primary cultures ofbovine articular chondrocytes:...
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Báo cáo y học: " Aging, osteoarthritis and transforming growth factor-β signaling in cartilage" pps
... cartilage in aging mice [2]. This commentary will discuss TGF-βsignaling and osteoarthritis in an experimental investigation in the mouse. It is important to bear in mind that results obtained in mice ... catabolic cyto-kines [1]. The aim of this commentary is to place in context arecent article in this journal of anabolic growth factor, trans-forming growth factor-β (TGF-β) signaling in articular ... protein; C-Smad = common Smad (Smad 4); IL = interleukin; LAP = latency-associated protein; MH = Mad homologydomain in the Smads; R-Smad = receptor-activated Smad (Smads 2 and 3 for TGF-β signaling;...
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Báo cáo y học: "Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts" potx
... H, Oni-shi Y, Inukai K, Anai M, Fukushima Y, et al.: 14-3-3 protein bindsto insulin receptor substrate-1, one of the binding sites ofwhich is in the phosphotyrosine binding domain. J Biol Chem1997, ... in OA Obs, unlike in normal cells. Since there is anincrease in IGF-1 production in OA Obs with a concomitantdecrease of the major insulin-like growth factor binding pro-teins, namely BP-3, ... activation via IRS-1 in OA Obs. We recently demon-strated that transforming growth factor (TGF)-β production isincreased in OA Obs [20] and, since this growth factor canactivate PKB in arthritis,...
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Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc
... -0.53138889_at ZFYVE9 Zinc finger, FYVE domain containing 9 (SARA) -0.53833831_at CREBBP CREB binding protein, CBP -0.53938311_at TGIF2 TGFB -induced factor 2 -0.5591734_at TGFB3 Transforming growth factor, ... protease inhibitors, resulting in enhancedproteolytic activity [41] and controls cell proliferation byprocessing the insulin-like growth factor-binding protein-1[42]. MMP-11 is, therefore, involved ... Red arrow indicates the cleavage site. CBP, CREB binding protein; LAP, latency-associated protein; LTBP, latent TGF-β binding protein; P, phosphate; TGFBR, TGF-β receptor; TGIF, TGFB-induced...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25