transforming growth factorβ regulation of immune responses
Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
... go to only one of thetwo daughter cells, leaving the other relatively clear of such signaling byproducts. A deeper understanding of the role of microtubules in the regulation of Smadtrafficking ... dissection of the molecular mechanisms of TGFb family signaling and the functional conse-quences thereof on cell responses. As far as Smad trafficking is concerned, althoughthe dynamic nature of such ... complexity anddepth of understanding of TGFb signaling increase, amost critical aspect of the whole signaling pathwayremains the sequence of specific steps and theestablishment of the complete...
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Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
... anti-inflammatorycytokine transforming growth factor-b1 (TGF-b1) of the proinflammatory cytokine TNF-a via the induction of FXR1 is the focus of this article.TGF-b1, a member of the large transforming growth factor-b ... tube: 20 lL of Optimem, 5 lgofeach plasmid, and 6 lL of Lipofectamine LTX (Invitrogen)and incubated at room temperature for 30 min. This mixturewas then added slowly to cells in 1 mL of Optimem. ... Molecular Medicine, School of Medical Sciences, University of Bristol, UK2 Department of Clinical Sciences South Bristol, Academic Unit of Ophthalmology, University of Bristol, UKIntroductionTumour...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
... Cell-specific regulation of human arylhydrocarbonreceptor expression by transforming growth factor-b1. Mol.Pharmacol. 59, 716 724.22. Doăhr, O. & Abel, J. (1997) Transforming growth factor-beta ... its down -regulation byTGF-b1.DISCUSSIONThe inhibition by TGF-b1 of SeP expression is to date theonly known regulation of this protein by a factor other thanthe availability of selenium. ... Overexpression of Smad 3 and 4, butnot of Smad 2, resulted in a marked down -regulation of SeP mRNA expression. Similar effects were observedfor luciferase expression under control of a human SeP-promoter...
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báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot
... biopsy-proven diagnosis.Measurements: Serum concentrations of transforming growth factor-beta1 and ferritin.Results: High concentrations of transforming growth factor-beta1 were noticed in patients suffering ... Medical School of Naples, Department of Biochemistry and Medical Biotechnology, Naples, Italy and 4Federico II University Medical School of Naples, Department of Neurosciences, Section of Clinical ... whether both the forms of non-alcoholic fatty liver disease were really dissimilar, evaluating theserum profile of two key parameters, indexes of severity.Methods: A total of 123 patients (57...
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báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
... degradation of Aβ42. Alsoibuprofen has been shown to reduce plaque-associatedand soluble Aβ42 in mice over-expressing the Swedishmutation of human APP [15,16]. The lack of effect of ibu-profen in ... Identification of the thioflavin-S-positive material willfacilitate the full appraisal of the clinical implication of the effects of anti-inflammatory drugs, and provide a more thoroughunderstanding of ... obstruction of CSF clearance bymeningeal fibrosis [34,35]. Other examples exist of hydrocephalus caused by growth factor-induced fibrosis[36]. The site and mechanism of action of pioglitazone...
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
... Robbins11Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, ... clinicalapplications of transforming growth factor-beta (TGF-beta). Growth Factors 1993, 8:1-9.3. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB: Transforming growth factor-beta in ... sequence analysis of simian transforming growth factor-beta cDNA. DNA 1987, 6:239-244.5. Miller DA, Pelton RW, Derynck R, Moses HL: Transforming growth factor-beta. A family of growth regulatory peptides.Ann...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
... 1Network-based analysis of downregulated genes in the functional category of immune responseNetwork-based analysis of downregulated genes in the functional category of immune response. (a) Network ... 2Network-based analysis of upregulated genes in the functional category of immune responseNetwork-based analysis of upregulated genes in the functional category of immune response. (a) Network ... pathophysiol-ogy of SLE.Figure 4Effect of cytokines or -estradiol on the expressions of interferon-inducible genesEffect of cytokines or -estradiol on the expressions of interferon-inducible...
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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
... tibia.Figure 3Percentage of cells expressing transforming growth factor (TGF)-beta in medial and lateral tibial cartilagePercentage of cells expressing transforming growth factor (TGF)-beta in ... RT, Heydemann A, Izumi T, Reddi AH: Regulation of theexpression of the type-II collagen gene in periosteum-derivedcells by three members of the transforming growth factor-betasuperfamily. J ... measurements, analyzedFigure 8Effect of transforming growth factor (TGF)-beta deprivation on intrinsic cartilage repair capacityEffect of transforming growth factor (TGF)-beta deprivation on...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... an in vitro measure of the in vivo efficiency of TGF-β1 activationTo examine the ability of SLE patients and control individualsto activate TGF-β1, a ratio of levels of TGF-β1 in freshly ... development of earlyatherosclerosis.Introduction Transforming growth factor (TGF)-β1 is the most potent natu-rally occurring immunosuppressant [1]; it is produced by allcells of the immune system ... proliferation and the fate of cells through apoptosis.In TGF-β1 knockout mice [2] lack of TGF-β1 initiates indiscrim-inate loss of self-tolerant T cells. Consequential dysregulation of B cell activity...
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Báo cáo khoa học: MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-jB1 ppt
... suppression of malignantphenotypes, suggesting the role of miR-9 in the growth inhibition of malignant cells.The fundamental function of miRNA is to regulatetheir targets by direct cleavage of the ... results indicated that the expressionlevel of miR-9 had an influence on cell growth. To fur-ther validate the antiproliferative effect of miR-9 onthe growth of ES-2 cells, a colony formation assay ... byinhibition of protein synthesis, according to the degree of complementarity with their target 3Â-UTRs. Identi-cation of miRNA target genes has been a greatFig. 5. Dysregulation of NF-jB1 in...
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Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... model of ErbB-1, based on thestructure of the type-1 insulin-like growth factor receptor[33], shows that the N-terminal part of domain II is involvedin a lobe of domain I [34]. Domain II of ErbB-1 ... F. (1993) A 40-kDa epidermal growth factor /transforming growth factor a-binding domainproduced by limited proteolysis of the extracellular domain of theepidermal growth factor receptor. J. Biol. ... receptor-bindingspecificities. The first group consists of EGF, transforming growth factor a, and amphiregulin, all of which binddirectly to ErbB-1. The isoforms of neuregulin (NRG, alsoknown as heregulin...
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transforming growth factor-beta protocols
... and properties of the cellular receptor for transforming growth factor type `. Biochemistry 25,3083–3091.3. Massagué, J. (1987) Identification of receptors for type-` transforming growth factor. ... Measurement of Active TGF-`2739. Sato, Y. and Rifkin, D. B. (1989) Inhibition of endothelial cell movement bypericytes and smooth muscle cells: activation of a latent transforming growth fac-tor-`1-like ... (1997) Transforming growth factor-` signal-ing in epithelial cells. Pharmacol. Ther. 75, 21.16. Jin, G. and Howe, P. H. (1997) Regulation of clusterin gene expression by trans-forming growth...
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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps
... limitanti-tumour or microbial immune responses. A strategicmanipulation of TRcells might thus be used either toenhance or to dampen immune responses as required.The identification of molecular markers, ... Mason D: Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmunethyroiditis in rats by peripheral ... characterisation of such autoimmune preventa-tive cells now leaves no doubt of the existence of TRcellsas crucial mediators of self-tolerance in both animalmodels and humans.ReviewA paragon of self-tolerance:...
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