transforming growth factorβ induces development of the th17 lineage
Báo cáo khóa học: Nerve growth factor mediates activation of the Smad pathway in PC12 cells doc
... phosphory-lation of the C-terminal SSXS-motif of the R-Smad. Basedon the diverse mechanism of Smad activation by eitherTGF-b1 or NGF, specific subsets of target genes might beinduced. The potential of NGF ... activate the Smad pathwayindependently of TGF-b might be of special importance inregulating the expression of genes that are essential for the development and function of neuronal cells or otherNGF-sensitive ... 33342 for 2 min and the cells were analysed by confocalmicroscopy. The projection of multiple sections is seen on the left for each panel to visualize the morphology of the cells. The middle row...
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Tài liệu Báo cáo khoa học: An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori docx
... achieved.Determination of the structure of 8K-BLPMALDI-TOF MS analysis of the purified materialfrom the final HPLC yielded a monoisotopic mass of 7409.2 ([M + H]+) (Fig. 3A). Amino acid sequenceanalysis of the ... days of cultivation, the number of the disk cells was approxi-mately 30% larger than in the control (Fig. 6M). Con-sidering the BrdU incorporation in specific areas of the disks (Fig. 6E), the ... Although the staining intensity of the cells increased during adult development, the number of fat body cells decreaseddramatically from mid-adult development onwards, dueto their disruption. These...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
... the assessment of the SeP mRNA expression and the measurement of luciferase activity exist. For example,whereas in the first case the species assessed is the mRNA(i.e. the respective cDNA) of ... margin of the known SeP promoter sequence, the 50flanking bases do not represent the context of the genomicpromoter but the sequence of the pBluescriptSKII 1plasmid. Hence, we deemed the second ... TGF-b-responsiveelement in the promoter of the SeP gene. In addition, wefound the expression of SeP mRNA being attenuated byoverexpression of Smad 3 and 4 which mimics activation of the TbR by TGF-b....
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... 3B). Theseresults indicate that the region spanning amino acids600–1099 of MAP2 (i.e. around the middle part of the CD) interacts with the endogenous v-KIND inmouse cerebellum.To verify whether ... under-stood, the data obtained in the present study indicatethat the 43 residues (amino acids 702–744 in mice) thatreside in the middle region of the CD act as the v-KIND binding core. The v-KIND-binding ... that the coresequence critical for the specific MAP2 binding resideswithin the 32 residues (amino acids 456–487) of the v-KIND KIND2 domain.To examine whether the MAP2 binding core site of v-KIND...
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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
... homology 1 domain of all Smads binds to importin-b in the case of Smad3and importin-a in the case of Smad4, while mutation of the NLS blocks the ability of these proteins to enter the nucleus [95–98]. ... complexity anddepth of understanding of TGFb signaling increase, amost critical aspect of the whole signaling pathwayremains the sequence of specific steps and the establishment of the complete time-lapse ... [108]. The role of Ran in mediating the export of proteins from the nucleus follows the inverse biochemical steps used forimport of proteins to the nucleus [100,102]. Ran–GTPpromotes the association...
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Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
... anti-inflammatorycytokine transforming growth factor-b1 (TGF-b1) of the proinflammatory cytokine TNF-a via the induction of FXR1 is the focus of this article.TGF-b1, a member of the large transforming growth factor-b ... expected, the control of TNF-a induction is not solely transcriptional.Addition of TGF-b1 induces the expression of factors that target the TNF-a 3Â-UTRMost cytokines contain an ARE in the 3Â-UTR of their ... LPS. The specificrole of FXR1 in this process was shown by inhibitionby siRNA on the one hand, and stable overexpression of FXR1 on the other. These results are consistentwith the phenotype of...
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báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot
... draft-ing the manuscript. GT conceived of the research, was the main investigator and the coordinator of the study, made the statistics and drafted the manuscript. All authors readand approved the ... this entity are the same ones that determine the more severe form. The key process in the progression of NAFLD from the very beginning to the end is fibrosis. An animal model of "fibrosing ... verify whether both the forms of non-alcoholic fatty liver disease were really dissimilar, evaluating the serum profile of two key parameters, indexes of severity.Methods: A total of 123 patients...
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báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
... irregardless of the intensity of Mac-1expression. The microglia were clearly activated (60% of all cells) at 2months of age, the earliest time analyzed (Fig 2B). The extent of activation was ... independent of inflammation. The possible therapeutic relevance of thisphenomenon lies in the nature of the Aβ measured that is:i) endogenous, ii) wild type, and iii) soluble, for the ani-mals ... degradation of Aβ42. Alsoibuprofen has been shown to reduce plaque-associatedand soluble Aβ42 in mice over-expressing the Swedishmutation of human APP [15,16]. The lack of effect of ibu-profen in...
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Báo cáo nghiên cứu khoa học " CLAM CULTURE DEVELOPMENT IN THE INTERTIDAL AREA: EFFECTS OF STOCKING BIOMASS ON GROWTH, SURVIVAL AND PRODUCTION OF THE TWO SIZES CLAM Meretrix lyrata " docx
... evaluate the effect of stockingbiomass of the two sizes of M. lyrataon growth performance and survival to enhance the production and profit of cultivation. The other parameters within the culture ... evaluation The estimation of the economic benefit of clamcultured in the intertidal areas is showed in table7. The net profit iscalculated based on the outputcost and input cost and price of the ... South of Vietnam. Due to highconsumption demand, the intertidal areas arebeing used for the cultivation of M. lyrataandthese practices expanded to the northern CARD 027/05 VIE– Development of...
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
... dose of the luciferase virus. (B) The naïve rabbit left knee with a low dose of the Ad.TGF-β1 virus and the right knee with a low dose of the luciferase virus. These images weretaken when the ... doses of adenovirus or the severe inflammationoccurring in the AIA model, the levels of white bloodleukocytic infiltrate in the synovial lavage fluids were deter-mined (Fig. 4). The joints of ... received the indicated dose of TGF-β1 virus in one knee and the same amount of the adenoviral vector expressing luciferase(Ad.Luc) virus in the opposite knee as the control.To lavage the rabbit...
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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
... and selected the cartilage. The computerthen measured the amount of blue light passing through the selected area. The higher the amount of light passing through, the lower the amount of PGs in ... resulted in a total block of the increased PGsynthesis, thereby reducing the intrinsic repair capacity of the cartilage. The reduced PG synthesis resulted in an aggrava-tion of the IL-1-induced PG ... judged by the observer were selected. The computer program determined the number of positive cells in the cartilage for the differentantigens. For each knee joint, the expression of the differentantigens...
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Báo cáo y học: "Foramen Magnum Arachnoid Cyst Induces Compression of the Spinal Cord and Syringomyelia: Case Report and Literature Review"
... incision was made on the skull via the posterior temporal route. The occipital squama was cut off and the posterior edge of the fo-ramen magnum and posterior arch of the atlas were then fully decompressed, ... excised due to the tight adhesion of the anterior wall of the cyst to the cervical spinal cord. A suture wound clo-sure of the dura mater was performed using artificial mesh repair. The postoperative ... compared to pre-surgery. The results of pathological examination showed that the wall of the cyst was composed of fibrous tissue but without epi-thelial cells; the diagnosis of arachnoid cyst was...
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