tourette s syndrome nicotine and animal models
Handbook of Tourette''''s Syndrome and Related Tic and Behavioral Disorders, Second Edition doc
... blepharospasm or Meige Motor and Vocal Tics syndrome should be considered voluntary because they are used as tricks to suppress the dystonic movements Tics Status or Status Tics Rarely, motor and ... Belmont, Massachusetts, U .S. A Loren Gianini Massachusetts General Hospital, Cambridge, Massachusetts, U .S. A Christopher G Goetz Rush University, Chicago, Illinois, U .S. A Stacy Horn Rush University, ... dystonia) is triggered by sudden movement or startle, lasts seconds to a few minutes, and is suppressed with anticonvulsant therapy Paroxysmal dystonic choreoathetosis is induced by stress, prolonged...
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Báo cáo sinh học: "Inequality of maximum a posteriori estimators with equivalent sire and animal models for threshold traits" pps
... a sire or an animal model The data consist of calving ease scores from 28 male and female calves born in herd-years from heifers and cows mated to sires Calving ease was scored as a response ... maximum a posteriori estimators and comparisons with the estimators and predictors of linear model methods have previously been based on sire models to describe the variable on the underlying scale ... Studies on the properties of maximum a posteriori estimators for threshold traits have been based on sire models to describe the underlying variable Interest has mainly focused on comparisons...
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báo cáo khoa học: "Gilles de la Tourette’s syndrome in a patient with 47(XXX) syndrome: a case report" ppt
... difficulties, a neuropsychological evaluation was proposed She was very shy with therapists and doctors of either sex; her lack of self-confidence was evident and manifested as requests for supplementary ... in Tourette syndrome J Neuropsychiatry Clin Neurosci 2010, 22:348-351 Roessner V, Plessen KJ, Rothenberger A, Ludolph AG, Rizzo R, Skov L, Strand G, Stern JS, Termine C, Hoekstra PJ, ESSTS Guidelines ... frontal lobes and EFs has also been advocated in TS [13] A recent paper suggested that patients with TS exhibit significantly poorer performances in theory of mind (ToM) tasks: these tasks imply...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... models Access to good animal models is crucial to success in developing disease-modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing animal models discussed, and ... assemblies of Ab trigger aggregation of tau and the formation of NFTs, but also inflammation and oxidative stress, by rather unclear mechanisms These downstream processes give rise to progressive ... experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of clinical samples The...
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Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
... absence of normal vascular support cells, such as smooth muscle cells To be histologically classified as a CCM, the lesion must contain multiple such vessels adjacent to each other (Fig 2) Grossly, ... this manuscript In human CCM disease, the lesions exhibit a number of characteristic features; these features will serve as guideposts on the road to developing animal models of CCM disease Classically, ... not CCMs, although it has been hypothesized that the disease progresses from a single capillary telangiectasia that blossoms into a multivessel CCM [13] Functionally, the lesion vessels are subject...
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báo cáo hóa học: " Primary Sjögren''''s Syndrome: health experiences and predictors of health quality among patients in the United States" potx
... depression in PSS is consistent with that of previous studies Valtysdottir measured psychological status in a Swedish cohort (N = 67) of PSS patients and reported that possible depression was present ... details on this scale see Additional file 1, Table S1 ); and, depressed mood with the Center for Epidemiologic Studies Depression Scale(CESD) [16] The PROFAD-SSI was also used to assess sicca severity ... patients to select 100 patients at random and recruit them for the study Subjects recruited through the Sjogren 's foundation (SSF-PSS) were classified as "possible" PSS if they reported a diagnosis...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... generally have similar pathological findings to the human disorders, distinct differences remain These models may be appropriate for studying some aspects of a disease process, while less suitable ... these proteins colocalize to the same neurons The presence of NFTs as well as SPs suggests that the 3xTg-AD and TAPP models may be more relevant than APP or APP/PS-1 mice for studying the significance ... is fibrillar (thioflavin -S reactive) increases up to years of age Matsuoka et al [98] described the CNS inflammatory response to Aβ in these animals Activated astrocytes and microglia increased...
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báo cáo hóa học:" Research Article On the Impact of Children’s Emotional Speech on Acoustic and Language Models" pdf
... classes are to be confused by the human labellers, the closer they are in this arrangement The quality of the NMDS result is given in Figure 1; it is assessed using Kruskal s stress function S and ... the improvements w.r.t the baseline system are significant (a) Scenario 1: “neutral versus emotional ASR engine” M Baseline system Adapted systems Acoustic models Linguistic models Both 43.6 E ... emotion-relates states, these four subsets contain different numbers of chunks The statistics are given in Table The “size” of the subsets are given in terms of the number of chunks and the number of words...
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Báo cáo y học: "Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren’s syndrome" pdf
... recombination biases predisposing to systemic autoimmunity in SLE and SS, there are some exceptions In some circumstances, specific autoantibodies express marked biases in IgV gene usage One example is the ... autoimmune diseases, such as pSS and SLE, seem to have characteristic abnormalities of particular censoring mechanisms IgV gene usage in patients with pSS is preferentially shaped by disordered selection ... Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH: European Study Group on Classification Criteria for Sjögren s Syndrome Assessment of the European classification...
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Báo cáo y học: "Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren''''s syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate" pptx
... autoimmune diseases such as RA and Crohn 's disease [13,28,29,39] make this cytokine a prime candidate also in the pathogenesis of SS Increased serum levels and salivary gland expression of IL18 ... with Sjögren 's syndrome (SS) (a–c,g–i) and in nonspecific chronic sialoadenitis (d–f) sialoadenitis (d–f) (a,b) Paraffin-embedded section of glands in SS, showing high amounts of IL-18-expressing ... GC-like structures identified as described in Materials and methods, and foci were classified as nonsegregated and segregated with or without GC-like structures drome (SS) (a–d) salivary gland ducts...
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Báo cáo y học: "Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren’s syndrome" pptx
... Porter SR, Richards A, Sauvezie B, Schiodt M, Sciuto M, Shoenfeld Y, Skopouli FN, Smolen JS, Soromenho F, Tishler M, Wattiaux MJ: Assessment of the European classification criteria for Sjögren s syndrome ... with SS (nd, not determined; ns, not significant) observed for the Vλ repertoire, this suggests a positive selection of these mutations in the parotid gland Discussion The present study has identified ... Gellrich S, Rutz S, Borkowski A, Golembowski S, Gromnica-Ihle E, Sterry W, Jahn S: Analysis of VH-DJH gene transcripts in B cells infiltrating the salivary glands and lymph node tissue of patients with...
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Báo cáo y học: "Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis" ppsx
... also presented spontaneous nose bleedings and macroscopic hematuria, although these symptoms were not observed in mice Joints were not affected in either species In tissue sections, aggressive ... association has been reported in RP The low number of RP patients as well as the paucity of studies on these patients complicates the genetic analysis Studies of animal models for RP and RA show ... inflammation and erosions of the affected cartilage confirmed the clinical signs (Fig 2) As measured by antibody response, all strains responded strongly to matrilin-1 and in some cases also to CII and...
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Báo cáo y học: "No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren''''s syndrome" pptx
... autoantibodies, in whom disease is usually less systemic Moreover, we previously reported that BAFF level was not associated with systemic features in pSS [8] Likewise, no association was found between ... Petersen K, Jonassen I, Jonsson R, Bolstad AI: Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren 's syndrome patients from healthy control subjects Arthritis ... T/C polymorphism and BAFF expression, and focused first on the correlation between BAFF polymorphism and serum level as assessed by enzyme-linked immunosorbent assay Interestingly, serum BAFF protein...
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Báo cáo y học: "B cells in Sjögren’s syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue" doc
... structures in a single biopsy reflects a snapshot of a slowly progressive inflammatory disease, pSS, or a subpopulation of patients with a more severe disease and/ or a distinct immune response ... autoantibodies occur in response to glandular tissue damage, apoptosis and/ or the expression of neoantigens such as cleaved La/SSB [85] and Ro/SSA-hYRNA complexes on the blebs of apoptotic glandular cells ... studies examining idiotype expression by glandular B cells in pSS have also suggested that these cells represent a selected population B cells expressing RFassociated cross-reactive idiotypes,...
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Báo cáo y học: "Biomarker profiles in serum and saliva of experimental Sjögren''''s syndrome: associations with specific autoimmune manifestations" ppt
... and entered simultaneously In serum no data were missing and in saliva missing values were excluded pairwise from all analyses except PCA and DA All analyses were computed using SPSS 13 (SPSS ... potential presence of SS-unrelated histopathology or of other subclinical autoimmune diseases in mouse models for SS represents a common problem of all mouse models used in SS research [13,31] This divergence ... have assessed interactions between several immune molecules and their association with disease parameters Summarizing findings regarding immune mediators such as cytokines in SS, it was concluded...
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Báo cáo y học: " Epitope spreading in animal models: array of hope in rheumatoid arthritis and multiple sclerosis" pot
... rather than hypothesis-testing The study from Kidd and colleagues [1] falls in the former group, in that it provides more questions than answers In the case of RA, some of the answers are already ... already partially addressed by the recent reports of new disease-specific autoantibodies In MS, the B cell autoantigens remain poorly characterised Nevertheless, the authors have presented an exciting ... transgenic animals could go a long way to analyse the autoimmune response in RA In MS, where the autoimmune response appears to be less MHC-restricted, better definition of the human autoantigens is required...
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Báo cáo y học: "Increased levels of circulating microparticles in primary Sjögren''''s syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity" pdf
... associated with systemic inflammation or excessive risk of thrombosis in various diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), vasculitis and antiphospholipid syndrome ... SLE [14,31], Crohn 's disease [32], systemic sclerosis [22], vasculitis [33-35] and myositis [36] Here we report the first assessment of circulating MPs in pSS An interesting finding was the significantly ... than in HCs In fact, similar results have been recently reported in systemic sclerosis [22] and Crohn 's disease [32] on assessment of MPs by flow cytometry and solid-phase capture assay, respectively...
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Báo cáo sinh học: "Estimating variances and covariances for bivariate animal models using scaling and transformation" pot
... models Another advantage is that the transformation can suggest more parsimonious models For example, one could consider a constrained model of the form: SES’ = S BS I, ST = B T and ST S AS ... [10] with respect to S shows that the estimates of S that AS BS [8] for given values of T and T satisfy maximize with si! _ ( ij -’) S The appendix shows that S can be found as the solution of ... a matrix of effects for the traits yi, y* and (Y c a x matrix of sums of squares and cross-products of residuals for these traits By using these relationships, and the formulae for log-likelihood...
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