tools for the synthesis of drug like molecule libraries

Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

Ngày tải lên : 19/02/2014, 12:20

... systems is therefore essential to prove the utility of the oocyte system and the validity of correlations based on the characterization of oocyte-expressed subunit combinations Nevertheless, the activity ... affinity for AuIB and ribbon sional structures and the relative ease of synthesis, makes AuIB is present in intracardiac ganglia, or that the a3b4* them particularly useful templates for the design of ... tissues The analysis of the DNA of different Conus species has already revealed a large number of a-conotoxin sequences [45] and the identification of further specific nAChR ligands is likely The advantage...

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Báo cáo khoa học: Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase doc

Ngày tải lên : 07/03/2014, 12:20

... l-gulono-1,4-lactone dehydrogenase of M tuberculosis is a specific enzyme for the biosynthesis of L-AA As far as we know, this is the first report of a specific biosynthetic enzyme for vitamin C in bacteria ... mutants of the gene could be obtained [40] The gene is well conserved within the M tuberculosis complex, except for the M bovis BCG Pasteur (1173P2) strain, which lost the gene due to the deletion of ... (ALO1), which catalyzes the last step in the biosynthesis of erythroascorbic acid in yeasts, resulted in attenuated virulence of the Candida albicans mutant [42] If synthesized by the Rv1771 l-gulono1,4-lactone...

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Báo cáo Y học: Guanosine diphosphate-4-keto-6-deoxy-D-mannose reductase in the pathway for the synthesis of GDP-6-deoxy-D-talose in Actinobacillus actinomycetemcomitans potx

Ngày tải lên : 17/03/2014, 10:20

... content of 48.0% [43] The GC content of the region essential for the biosynthesis of SPA in the other serotype strains (b–e) of A actinomycetemcomitans is also lower than the average GC content of these ... gene clusters responsible for the biosynthesis of SPAs of A actinomycetemcomitans serotypes a, b, c, d, and e [23,29,34–36] The gene cluster associated with the synthesis of SPA in A actinomycetemcomitans ... involving the gmd gene products halted after consuming some of the GDP-a-D-mannose, regardless of the addition of the proteins The peak that appeared at 24.0 was in agreement with that of authentic...

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Báo cáo khoa học: "SOFTWARE TOOLS FOR THE ENVIRONMENT OF A COMPUTER AIDED TRANSLATION SYSTEM" pptx

Ngày tải lên : 17/03/2014, 19:21

... translator This data base is composed of dictionaries, "formats" and "procedures" of the analysis, transfer and synthesis phases (the conventional phases of a CAT system) For any given source lexical ... two factors : the dispersal of information and the obscurity of the coding In ARIANE-78, the lexical data base may reside on much more 50 files, for a given pair of language Figure Screen Display ... VISULEX searches for all the associated information THAM consists of a set of functions programmed in the macro language associated with a powerful text editor These functions help the translator...

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solvothermal reactions- an original route for the synthesis of novel materials

Ngày tải lên : 20/03/2014, 13:08

... properties of the selected solvent can also play an important role for orienting the structural form of the ﬁnal material Lu et al [24] have underlined that the solvothermal synthesis of MnS can ... isostructural of the high pressure form of Zn2SiO4) (Fig 5) J Mater Sci (2008) 43:2104–2114 Solvothermal reactions have been investigated for the C3N4 synthesis The ﬁrst consisted on the condensation of ... appear to be important for either the synthesis of novel materials, the preparation of nanostructured particles for nanotechnologies or the elaboration of bio-inspired materials for applications in...

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Báo cáo khoa học: Afﬁnity puriﬁcation-mass spectrometry Powerful tools for the characterization of protein complexes ppt

Ngày tải lên : 31/03/2014, 07:20

... afﬁnity-based methods The common theme of these is the use of an inherent interaction (afﬁnity) of two biomolecules If one of the molecules is immobilized on a solid support, the interacting molecule can ... and that the results are usually straightforward to interpret The downsides are the statistical limitations imposed by the method These include the requirement that the majority of the coding ... in the sequence (Fig 2) Quite often, only a part of the sequence can be read from the sequence However, this stretch of consecutive sequence is ÔlockedÕ within the peptide by the masses of the...

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a novel method for the synthesis of titania nanotubes using

Ngày tải lên : 05/05/2014, 15:26

... formation continuing until repassivation occurs [17,19] Nanotube formation goes through the diffusion of F− ions and simultaneous effusion of the [TiF6 ]2− ions The faster rate of formation of ... magnetic stirring The saturation of current with time indicates the development of repassivation, the saturation of nanotube formation These results are in line with the ﬁndings of our FESEM studies ... explained by the faster mobility of the F− ions into the nanotubular reaction channel and effusion of the [TiF6 ]2− ions from the channel It is well known that the cavitation effect of ultrasonication...

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a novel method for the synthesis of cao nanoparticle

Ngày tải lên : 06/05/2014, 08:55

... emulsions for detoxification of pesticides suitable process for synthesis of nanoparticles [1] Certain disadvantages exist with the use is using of Co-Precipitation method [28, 29] of these adsorbents ... These substances also control both towards the toxicants makes them the potential the reduction rate of metal ions and the materials for the decomposition applications agglomeration process of ... performance for the decomposition of the final temperature (for min); the temperature 2-CEPS was increased at rate of 20 oC/ for 13 Also, detector temperature was 230 oC Experimental Materials Synthesis...

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solgel based hydrothermal method for the synthesis of 3d flowerlike zno microstructures

Ngày tải lên : 06/05/2014, 13:26

... patterns of the ZnO sample synthesized at 120 ◦C for 17 h hydrothermal treatment Figure a b d e c f Fig SEM images of the time-dependent evolution in the formation of 3D flower -like ZnO synthesized ... of the formation process of the 3D flower -like ZnO Figure Fig (a) Bar graph illustration of the photocatalytic degradation of KGL using ZnO samples synthesized at 120 ◦C for different hydrothermal ... from the semiconductor, the holes can diffuse to the surface of the semiconductor and cause oxidation of the organic dye Therefore, a high density of surface oxygen defects is beneficial for efficient...

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Báo cáo hóa học: " A rapid, convenient, solventless green approach for the synthesis of oximes using grindstone chemistry" docx

Ngày tải lên : 20/06/2014, 22:20

... furnish the pure oxime in 60-98% yield 90 Page of run might be due to the loss of active sites of the catalyst Conclusions To the best of our knowledge, Bi O has never been used in the synthesis of ... grounded in a mortar with a pestle for the required period of time On completion of the reaction as Table Reusability of Bi2O3 in the preparation of 2b using 60 mol% of the catalyst Entry Run number ... characterization of carbonyl compounds [1,2].Conversions into nitriles [3], nitro compounds [4,5], nitrones [6], amines [7], and synthesis of azaheterocycles [8] are some of the synthetic applications of oximes...

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Báo cáo hóa học: " An alternative route for the synthesis of silicon nanowires via porous anodic alumina masks" potx

Ngày tải lên : 21/06/2014, 01:20

... distribution The inset of (b) shows the Au nanoparticle The inset of (c) corresponds to the EDX analysis of the Si NWs shows the histogram plot for the diameter distribution of the synthesized Si ... the pores of the AAO mask and will be responsible for the constant dimensions of the synthesized nanowires Figure shows the surface of the AAO-Si substrate, once the Figure Diagram of the CVD system ... growth The Si used in the growth process of nanowires is obtained from thermally generated defects on the surface of Si (100) These defects can be observed subsequently to the synthesis of Si...

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Báo cáo hóa học: " Effect of ion implantation energy for the synthesis of Ge nanocrystals in SiN films with HfO2/SiO2 stack tunnel dielectrics for memory application" pot

Ngày tải lên : 21/06/2014, 05:20

... varying the implantation parameters and annealing condition The dependence of implantation energy for the formation and evolution of Ge-NCs in these stack structures were studied further Experimental ... no Ge-NC was observed for sample A3 The SiN layer underwent a swelling of about nm, whereas the thickness of the underlying HfO and SiO layers remain almost the same as in the as-deposited sample ... In the images, the surface of SiN layer is indicated by a white line accumulation layer of the substrate), resulting in a shift of the C-V curve toward negative voltages [21,22] In general, the...

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báo cáo hóa học:" Minireview: Transaminases for the synthesis of enantiopure beta-amino acids" doc

Ngày tải lên : 21/06/2014, 17:20

... potential for the synthesis of optically pure βamino acids These pyridoxal 5’-dependent enzymes catalyze the transfer of an amino group from a donor substrate to an acceptor, thus enabling the synthesis ... necessity for external cofactor recycling and the enzymes’ high enantioselectivity and reaction rate For the synthesis of enantiopure β-amino acids only a limited number of TAs are available Therefore ... of Lys258 then acts as a catalyst for the 1,3-prototropic shift to form the ketimine The ketimine is hydrolyzed to yield the keto acid and PMP The following second half reaction consists of the...

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Báo cáo hóa học: " A Temperature Window for the Synthesis of Single-Walled Carbon Nanotubes by Catalytic Chemical Vapor Deposition of CH4 over Mo2-Fe10/MgO Catalyst" pptx

Ngày tải lên : 22/06/2014, 00:20

... study the inﬂuence of growth temperature on the purity of prepared tube samples, we give the curve (Fig 4) showing the dependence of ID/IG on the growth temperature From Fig 4, two kinds of ID/IG ... temperature was raised to the setting value in Ar atmosphere at a ﬂow rate of 200 mL/min before CH4 was introduced into the reactor at 60 mL/min for 30 min, then CH4 was turned off and the furnace was ... accords with the result of the TEM image (Fig 3a) The intensity ratio, ID/IG, is observed to decrease with increasing temperature (at 800 °C, the ID/IG is 0.47) Raman spectrum of the sample grown...

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Báo cáo hóa học: " A Versatile Route for the Synthesis of Nickel Oxide Nanostructures Without Organics at Low Temperature" doc

Ngày tải lên : 22/06/2014, 01:20

... only size, the geometry, and chemical homogeneity, but also the simplicity and practicability of synthesis techniques When developing a synthesis method for generation of nanostructures, the most ... For the micro-structural analysis, the as-synthesized samples were directly transferred to the FESEM chamber without disturbing the original nature of the products Figure shows FESEM images of ... almost uniform spherical nanoparticles were produced for sample heated at 100 °C for 12 h (Fig 1b) The diameters of the nanoparticles are in the range of 50–70 nm with an average diameter of 60 nm...

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Báo cáo hóa học: "Single step process for the synthesis of carbon nanotubes and metal/alloy-ﬁlled multiwalled carbon nanotubes" docx

Ngày tải lên : 22/06/2014, 22:20

... spectra of the alloy-filled MWNTs (Fig 2a) showed the presence of Zr, Cr, Fe and Ni; the constituents of the alloy, with a composition comparable to that of the initial alloy used for the preparation ... Dependence of carbon yield on the reaction temperature be through the precipitation of carbon in the form of MWNTs from the molten catalytic particles The melting temperatures of the alloy-C ... 388.9 cm–1, in addition to the G- and Dbands The increase in the intensity of D-band for Nifilled MWNTs is due to the non-uniform filling of Ni, resulting in increased degree of disorderness Alloy nanowire...

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báo cáo khoa học: " Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s disease" doc

Ngày tải lên : 11/08/2014, 12:21

... encompass only informatics and statistics; for example, it includes the development of tools not only for storing and mining the data, but also modeling of the data in the context of disease pathophysiology ... beyond the pathways The genetics of late-onset AD is complex, although several of the common risk alleles other than APOE are involved in production, aggregation and removal of Aβ [33] Several of the ... affect the mobility of Aβ peptides, including dynamics of their self-assembly Lipidomics tools are now available for detailed studies of molecular lipids in cells and biofluids [48] Molecular profiling,...

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Development of new methodologies for the synthesis of enantiomerically enriched compounds

Ngày tải lên : 16/09/2015, 08:30

... DEVELOPMENT OF NEW METHODOLOGIES FOR THE SYNTHESIS OF ENANTIOMERICALLY ENRICHED COMPOUNDS LEE CHENG HSIA ANGELINE (B.ApplSc (Hons.), NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... alcohols, there are no reported illustrations for the synthesis of the cis-linear regioisomer Herein, an effective and unusual approach towards the synthesis of enantiomerically cis-linear homoallylic ... during pregnancy for the treatment of morning sickness However, the drug in the racemic form caused a wave of birth defects It was later found that the R isomer is teratogenic, but the S isomer is...

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Part development of novel methods for the synthesis of homoallylic alcohols part II multigrams synthesis of ( ) epibatidine

Ngày tải lên : 16/09/2015, 17:11

... DEVELOPMENT OF NOVEL METHODS FOR THE SYNTHESIS OF HOMOALLYLIC ALCOHOLS PART II : MULTIGRAM SYNTHESIS OF (−)-EPIBATIDINE KEN LEE CHI LIK B.Sc (Hons.), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF ... iii SUMMARY PART I: Development of Novel Methods for the Synthesis of Homoallylic Alcohols In the development of novel methods for the synthesis of homoallylic alcohols, two conceptual strategies ... large scale synthesis of epibatidine However, if not for the generous assistance from the following people, I would not have “survive these ordeals.” I would therefore like to thank the following...

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Báo cáo hóa học: " Iron Oxide Nanoparticles Employed as Seeds for the Induction of Microcrystalline Diamond Synthesis" pdf

Ngày tải lên : 21/06/2014, 22:20

... occurs densiﬁcation of trigonally and tetrahedrally bonded carbon around the iron nanoparticle and the impending formation of diamond bonds From the above analysis, the synthesis of nFeO-induced ... lead to the formation HO and CO radicals, creating active nanoscale iron surfaces for the adsorption and decomposition of the incoming carboncontaining species, and thus for the formation of nanoscale ... successfully induced on them by nFeO Another important difference is the diamond quality of the nFeO-induced diamond ﬁlms according to their Raman spectra The bonding structure of the material was determined...

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