to and different from the scalp
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
Ngày tải lên :
14/02/2014, 19:20
... [9] The KIND domain in these proteins is localized to the N-terminal region, and their specific functional domains are located in the C-terminal region The C-lobe of protein kinases mediates the ... between v-KIND and MAP2 (A) Alignment of the KIND2-1 region in human, mouse and Gallus (top) and the corresponding mouse v-KIND KIND1, Spir-2 KIND and PTPN13 KIND domains (bottom) The residues ... be interesting to determine whether a hydrophobic interaction between the Leu residues from v-KIND and MAP2 contributes to the interaction between the two proteins In conclusion, the present study...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
Ngày tải lên :
06/03/2014, 09:22
... C106 then binds to the ectodomain of the transmembrane receptor Toll and thereby initiates a cytoplasmic signaling pathway, resulting in the release of a rel family transcription factor Dorsal from ... activation of serine proteinases to produce an active Toll ligand called Spatzle [4,6] The ¨ Spatzle ligand and Toll receptor also establish the dor¨ sal–ventral axis in the Drosophila embryo, although ... primers encoding the start and stop codon regions (Table S1) The products were cloned into TOPO PCR 4.0 T vector, and the nucleotide sequences were confirmed by DNA sequencing Amplification and sequencing...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
Ngày tải lên :
06/03/2014, 11:20
... Raising the temperature from 298 to 313 K leads to a significant decrease in the intensities of all the NOEs arising from the HN of Gly337 and all the sequential and medium-range NOEs arising from the ... zinc-binding domain of the zinc finger protein Ynr046w [25] (Fig 8) The fit of the heavy atoms (Ca, C, and N) from three b-strands and the a-helices of both the closed and the open conformer onto a corresponding ... of the C-domain, still retains its RF activity [15] The combination of the human M-domain and C-domain, in the absence of the N-domain, is able to bind to the mammalian ribosome and to induce the...
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Báo cáo khoa học: Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2 pdf
Ngày tải lên :
30/03/2014, 10:20
... able to convert 3SM This raised the question of whether all CMLEs from the ‘traditional’ protocatechuate degradative pathways are also able to convert 3SM We decided to analyze the CMLE from the ... side positive and the other side hydrophobic, but the identity of the residues is completely changed The change from PpCMLE Leu317A to ArCMLE1 Gly314A, together with a reorientation of the C-monomer ... below the active site The view is from the top of the active site Water molecules are shown as red spheres The coloring of the chains is the same as in (A) Some of the residues surrounding the...
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structure and function of the arabic verb
Ngày tải lên :
03/04/2014, 12:48
... CLAUSES, AND METHODOLOGY of the clause, is very indicative, in our opinion, of the adequacy and the basis of this orientation, on the one hand, and the destiny of linguistics, on the other hand Of ... representations, on the one hand, and their semantic interpretations, on the other hand VERBAL FORMS, CLAUSES, AND METHODOLOGY This chapter focuses, in particular, on the status and characteristics of these ... expressing the time of the event, that is, X took place yesterday Thus, we can see the extent to which modal cases are different from the propositional case roles demanded by the meaning of the verb...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 1 pps
Ngày tải lên :
11/08/2014, 06:21
... understanding of the anatomy and function of the ear and the auditory nervous system, and it discusses the cause and treatment of hearing disorders Most books on hearing focus either on the anatomy and function ... find original work on the different subjects Understanding of the anatomy and the function of the auditory system together with knowledge about the pathophysiology of the auditory system are essential ... joint The head of the malleus and the incus are fused together in a double saddle joint and the joint between these two bones is regarded to be rigid The joint between the incus and the stapes is...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 2 ppsx
Ngày tải lên :
11/08/2014, 06:21
... because the mass of the tectorial membrane varies along the membrane and the length (and thereby the stiffness) of the hairs also varies along the basilar membrane These resonators together with the ... of sounds by the head and the pinna varies from to 21 dB depending on the angle to the sound source in the horizontal plane (azimuth) The shadow and baffle effects of the head and the outer ear ... EAR AND EAR CANAL The ear canal, the pinna and the head influence the sound that reaches the tympanic membrane The influence of these structures is different for different frequencies and the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 4 potx
Ngày tải lên :
11/08/2014, 06:21
... drawing of the connections from the ICC to the ICX and the DC, and connections from these structures to other nuclei Also shown is the efferent input from the cerebral cortex to the ICX (From Møller, ... their input from the ICC and the ICX The posterior division of the MGB (PO) receives input from the ICC and projects to the AAF cortical area The neurons in the ventral portion of the auditory thalamus ... nuclei) [3] and from the visual and the vestibular systems [11] The dorsal division of the MGB projects to the AII and the PAF cortical fields (Fig 5.10) rather than the primary auditory cortex...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 6 pot
Ngày tải lên :
11/08/2014, 06:21
... difference between the latency of the N1 of the AP and that of the response from the intracranial portion of the auditory nerve is the travel time in the auditory nerve from the ear to the recording ... similar to the AP recorded from the round window of the cochlea as described in Chapter In the cat the latency of the N1 in the response recorded from the auditory nerve in the internal auditory ... line between the middle of that line and the vertex The origin of the vectors is the latency of the first peak in the dipole and the length is the relative strength of the dipoles Note the short...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 7 pot
Ngày tải lên :
11/08/2014, 06:21
... decreases the input to the cochlea and thereby decreases the contraction of the stapedius muscle, and that in turn causes the input to the cochlea to again increase, and that increases the contraction ... over 100 ms The individual variation is large The latency of the response to 1.5 kHz tones is shorter than the response to 0.5 kHz tones [182] The latency of the ipsilateral and the contralateral ... muscle The thick continuous line shows the difference between the articulation scores when the sound was led to the unaffected ear and obtained when the sounds were led to the affected ear at the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 8 docx
Ngày tải lên :
11/08/2014, 06:21
... exposure to pure tones The data were pooled from many nerve fibers and the frequency scale is normalized The arrows show the frequency of the exposure tones and the different curves represent different ... easy to measure the amplitude of both AP and SP (Fig 9.22) Note that the polarity of the SP is different in response to tones of different frequency It has been the ratio between the SP and the ... causes symptoms and signs of disease because of expression of neural plasticity may be different from that to which the patient refers the symptoms and it may be different from the anatomical location...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 9 pdf
Ngày tải lên :
11/08/2014, 06:21
... have the best possible knowledge and understanding of the changes in the function of the auditory system that can lead to tinnitus and hyperacusis in order to be able to help individuals with these ... deprivation due to the conductive hearing loss, and the observed reduction of tinnitus after restoring hearing may be explained by restoration of normal sound input to the cochlea and thereby to the CNS ... formant frequencies and other speech features and then code these features in the pattern of impulses that are applied to the cochlea to stimulate the auditory nerve Processors such as the Nucleus device...
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Báo cáo y học: "Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the protein" ppsx
Ngày tải lên :
14/08/2014, 14:21
... with the exception of the ovaries, which were taken from females Tissue was pooled from between four to six animals, the RNA extracted and 10 mg of total RNA was labeled and then hybridized to the ... table and the test statistics of these were used to form an estimate of their distribution under the null hypothesis, to which the observed test statistic can be compared Additional data files The ... age and tissue expression other than through their common connection to recent rate of evolution The connection between rate and tissue specificity in each of these sample sets is identical to the...
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EXPRESSION AND FUNCTION OF THE PRL FAMILY OF PROTEIN TYROSINE PHOSPHATASE
Ngày tải lên :
24/08/2014, 11:44
... in the vascular endothelial cells, fibroblasts, and lymphocytes of the choroids, in the corneal epithelium and endothelium, and in the fibroblasts of the cornea and sclera In the corneal epithelium, ... cartilage In the urinary bladder, PRL-1 appeared to be localized to the more immature, intermediate, and basal cell layers of the uroepithelium and not to the more differentiated and highly specialized ... of PRL-1 mRNA and strong expression of PRL-2 mRNA in the glandular epithelia of the prostate (A,B), urothelia of the bladder (C,D), and glomeruli and tubules of the kidney (E,F) In the urinary...
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Regulation and function of the novel candidate tumor suppressor gene dlec1 in the HCT116 colorectal cancer cell line
Ngày tải lên :
16/10/2015, 15:37
... originating from the epithelial cells lining the gastrointestinal tract The transition from normal epithelium to carcinoma is associated with acquired molecular events (Fearon and Vogelstein, 1990) There ... novel therapeutic strategies and drugs to treat and to overall improve the quality of life of CRC patients Recently novel targeted therapy against angiogenesis and epidermal growth factor receptor ... become the therapeutic targets of colorectal cancer because studies from recent years provided emerging evidences that growth factor receptors and the downstream signaling pathways coupled to them...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
Ngày tải lên :
17/02/2014, 19:20
... organisms and the roles of organisms on the fluxes and storage of energy and materials in ecological systems The theoretical predictions provide baselines from which to measure and understand the influences ... ranging from zooplankton to fish The slope of this relationship, 0.23, is very close to the theoretically predicted value of 1/4, and the fitted regression accounts for the THE METABOLIC THEORY ... be applied to make more explicit and quantitative links between the processing of energy and elements at the individual level to the flux, storage and turnover of these elements at the level of...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
Ngày tải lên :
18/02/2014, 16:20
... function The left-hand inset shows an overview of the theoretical curve and the fitting line to highlight the two intercept points The right-hand inset shows Tyr25 correlation, which occurs outside the ... time, sm The points from N-terminal and C-terminal residues (Arg1–Leu7 and Ala60–Gln67), together with those from Arg58 and Gln59 in the C-terminal end of helix III, are located apart from the major ... Fig The localization of the experimental points in Fig along the correlation line is directly related to the distribution of the energy between the overall tumbling and the internal mobility, and...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
Ngày tải lên :
19/02/2014, 06:20
... and kidney To compare the amounts of the two variants expressed in the testis, we performed the PCR using the primers ‘d’ and ‘c’, where the cDNAs for both Noxo1b and Noxo1c are amplified as the ... testis but only slightly in the colon On the other hand, the Noxo1b mRNA was relatively abundant in the colon and also present in the testis, liver, thymus, and kidney but to a lesser extent (Fig ... leading to superoxide production On the other hand, Noxo1 lacks the autoinhibitory region [15,17,18]; its SH3 domains are capable of binding to p22phox even in a resting state [15] This seems to explain...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
Ngày tải lên :
19/02/2014, 12:20
... contributes to the formation of the hydrophilic pore ACh binding protein has structural and functional homology to the extracellular ligand binding domain of the nAChR, and likewise assembles into pentamers ... of the conotoxins and their highly specific action on different ion channel subtypes derives from the structure of the peptides which have evolved conserved and hypervariable regions [27–30] The ... target the muscle-type nAChR The largest family are the a-conotoxins which can be further divided into a3/5, a4/3, a4/6 and a4/7 structural subfamilies The a3/5 conotoxins GI, MI, SI, SIA and SII...
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